Preparation method of silicon dioxide inverse opal hydrogel photonic crystal beads

A technology of photonic crystal microspheres and silica, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the cumbersome preparation method of silica inverse opal hydrogel photonic crystal microspheres and the difficulty of preparing silica nanoparticles , accuracy, sensitivity gap and other issues, to achieve the effect of batch preparation, simplified production process and uniform particle size

Inactive Publication Date: 2019-06-07
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The traditional stober method of synthesizing silica spheres is difficult to ensure that the synthesized silica nanoparticles have a uniform particle size, so it is difficult to ensure that the silica nanoparticles can be assembled into photonic crystal templates. In addition, due to the inverse opal hydrogel The preparation process of photonic crystal microspheres is cumbersome, which limits the large-scale application of inverse opal photonic crystal microspheres in the detection field
[0004] Compared with traditional detection methods such as GC-MS, HPLC, and ELISA, the liquid-phase chip detection system based on silica inverse opal hydrogel photonic crystal microspheres is still in an auxiliary and secondary position in the detection of food toxins. The reason is mainly due to the following defects. 1) Although the detection speed has been greatly improved, there is still a certain gap in the accuracy and sensitivity of detection compared with traditional methods; 2) Silica nanoparticles with uniform particle size and visualized silica The preparation method of inverse opal hydrogel photonic crystal microspheres is cumbersome

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  • Preparation method of silicon dioxide inverse opal hydrogel photonic crystal beads
  • Preparation method of silicon dioxide inverse opal hydrogel photonic crystal beads
  • Preparation method of silicon dioxide inverse opal hydrogel photonic crystal beads

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Embodiment 1

[0044]The preparation steps of the traditional stober method to synthesize silica nanoparticles are as follows:

[0045] References Controlled growth of monodisperse silia sphere in the micronsize range. Synthesize silica nanoparticles with a particle size of 300nm according to the method provided in the literature. The specific steps are:

[0046] Add four milliliters of pentyl esters, four milliliters of ammonium hydroxide, fifty milliliters of saturated alcoholic ammonia solution (mixed solution of ethanol and ammoniacal liquor) in the reaction flask of 250 milliliters, seal bottle mouth with rubber stopper, magnetic stirring condition Two milliliters of tetraethylorthosilicate was added, and the reaction was carried out for ten hours. Wash the silicon spheres with absolute ethanol three to five times to remove unreacted ammonia, ethanol and other impurities in the reaction liquid, resuspend the silica nanoparticles obtained by centrifugation with double distilled water, an...

Embodiment 2

[0048] A method for preparing silica inverse opal hydrogel photonic crystal microspheres, the preparation steps are as follows:

[0049] 1) Synthesis of silica nanoparticles with uniform particle size:

[0050] (1) Take 45mL of absolute ethanol and 5mL of tetraethyl orthosilicate respectively, add the above two substances into the reaction beaker, and then seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol. The above solution was ultrasonically treated for 20 minutes to fully disperse tetraethyl orthosilicate in absolute ethanol;

[0051] (2) Take 5mL of ammonia water and 20mL of absolute ethanol respectively, add the above two substances into the reaction beaker, add 15mL of double distilled water, and seal the mouth of the beaker with plastic wrap to prevent the ammonia water and ethanol from volatilizing. under magnetic stirring conditions. Mix the solution thoroughly and evenly;

[0052] (3) Use a syringe pump to inject the solution ...

Embodiment 3

[0064] A method for preparing silica inverse opal hydrogel photonic crystal microspheres, the preparation steps are as follows:

[0065] 1) Synthesis of silica nanoparticles with uniform particle size:

[0066] (1) Take 43mL of absolute ethanol and 7mL of tetraethyl orthosilicate respectively, add the above two substances into the reaction beaker, and then seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol. The above solution was ultrasonically treated for 20 minutes to fully disperse tetraethyl orthosilicate in absolute ethanol;

[0067] (2) Take 7mL of ammonia water and 8mL of absolute ethanol respectively, add the above two substances into the reaction beaker, add 15mL of double distilled water, and seal the mouth of the beaker with plastic wrap to prevent the ammonia water and ethanol from volatilizing. under magnetic stirring conditions. Mix the solution thoroughly and evenly;

[0068] (3) Use a syringe pump to inject the solution o...

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Abstract

The invention provides a preparation method of silicon dioxide inverse opal hydrogel photonic crystal beads, which involves two parts of content: (1) preparation of uniformly-sized silicon dioxide nanoparticles; and (2) preparation of a solution of certain concentration as an internal solution from the uniformly-sized silicon dioxide nanoparticles, and use of dimethyl silicone oil as an external solution. By adjusting the flow rate of an injection pump, the amount of liquid transported through an opposite-flushing capillary micro droplet device can be controlled, and then, the size of the generated silicon dioxide photonic crystal beads can be controlled. The silicon dioxide inverse opal hydrogel photonic crystal beads prepared by the method have many advantages over the traditional inverse opal photonic crystal films. The preparation process is simplified by means of the opposite-flushing capillary micro droplet device. Moreover, the inverse opal photonic crystal beads have a perfectsymmetry structure and angle-independent reflection peaks, and can realize naked-eye detection of an object to be detected.

Description

technical field [0001] The invention relates to the field of biological monitoring, in particular to a method for preparing silicon dioxide inverse opal hydrogel photonic crystal microspheres. Background technique [0002] Food toxins are secondary metabolites produced by fungi. Due to their characteristics of trace amounts, strong toxicity, various types, and the coexistence of multiple toxins in the same food, it brings great difficulties to actual detection. At present, the detection methods of mycotoxins in food include gas chromatography-mass spectrometry (GC-MS), high-performance liquid chromatography (HPLC), and enzyme-linked immunosorbent assay (ELISA). However, due to limitations such as complicated sample pretreatment, cumbersome operation, and the need for expensive experimental instruments, it cannot meet the requirements of on-site rapid screening. Therefore, in the process of food toxin detection, those skilled in the art have been looking for a fast, accurate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
Inventor 王汉杰崔梅慧常津杨旻晔李姗姗魏春阳于成壮
Owner TIANJIN UNIV
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