Porous resin microparticles and method for producing the same
A manufacturing method and porous technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve problems such as poor productivity, great labor to remove impurities, and adverse effects caused by the environment, and achieve optical properties Excellent, narrow particle size distribution effect
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Embodiment 1
[0126] Into a 1500mL autoclave, 36g of polybutylene succinate (GS-Pla number manufactured by Mitsubishi Chemical Corporation: FZ-71PD, PBS, melting point: 113°C) as a biodegradable resin and 1164g of 3-methoxy 3-Methyl-1-butanol (Sol-fit Fine grade manufactured by Kuraray Co., Ltd.) was used as a solvent, and stirred at a heating stirring temperature of 120° C. and a stirring rotation speed of 600 rpm for 60 minutes.
[0127] Then, the contents were taken out after allowing to cool naturally (60 minutes to 25° C.) while maintaining the number of rotations of the stirring. By subjecting the contents to dehydration / filtration / drying, such as figure 2 The porous resin microparticles shown in the electron micrographs of (a) and (b). figure 2 (a) is a 200 times photo, figure 2 (b) is a photograph of 1500 times.
Embodiment 2a
[0129] In addition to using 60 g of polylactic acid (Unitika company's Terramac number: TE-2500, melting point: 166 ° C) as a biodegradable resin, and using 1140 g of 3-methoxy-3-methyl-1-butanol (Kuraray company Sol-fit Finegrade), and the heating and stirring temperature is set to 140°C, except for rapid cooling (up to 25°C for 30 minutes) instead of natural cooling, the rest are operated in the same way as in Example 1 to obtain the following image 3 The porous resin microparticles shown in the electron micrographs of (a) and (b). image 3 (a) is a 200 times photo, image 3 (b) is a photograph of 1500 times.
Embodiment 3
[0131] In addition to using 90g of polybutylene succinate, 1110g of 3-methoxy-3-methyl-1-butanol (Sol-fit Fine grade manufactured by Kuraray Company), and rapid cooling (up to 25°C) 30 minutes) to replace natural cooling, all the other operate in the same way as in Example 1 to obtain such Figure 4 The porous resin microparticles shown in the electron micrograph of . Figure 4 For 1000 times the photo.
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