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Method for preparation of coating against drug-resistant bacteria on medical catheter surface

A technology for medical catheters and drug-resistant bacteria, which is applied in the direction of pharmaceutical formulations, catheters, coatings, etc., can solve the problem that antibacterial coatings cannot effectively kill drug-resistant bacteria, and prevent methicillin-resistant Staphylococcus aureus and The formation of vancomycin enterococcus biofilm, the effect of killing drug-resistant bacteria and solving the problem of poor binding force

Inactive Publication Date: 2018-06-15
周超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the defect that the antibacterial coating on the surface of the medical catheter in the prior art cannot effectively kill drug-resistant bacteria, and provide a method for preparing an anti-drug-resistant bacterial coating on the surface of the medical catheter

Method used

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  • Method for preparation of coating against drug-resistant bacteria on medical catheter surface
  • Method for preparation of coating against drug-resistant bacteria on medical catheter surface
  • Method for preparation of coating against drug-resistant bacteria on medical catheter surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A kind of anti-drug-resistant bacteria coating is prepared on the surface of medical catheter, comprising the following steps:

[0034] 1. Soak several polyolefin medical catheters in Tris buffer solution containing dopamine, react at 37°C for 24 hours, then wash with distilled water and dry in vacuum. The concentration of the Tris buffer solution is 4 mg / ml, the pH of the Tris buffer solution is 8.4, and the surface amination-modified polyolefin medical catheter is obtained.

[0035] 2. Put several surface amination-modified polyolefin medical catheters into ethyl acetate solvent, the volume of ethyl acetate is 20ml, then add 0.05g / ml 4-dimethylaminopyridine, 0.08g / ml triethylamine , 0.2g / ml bromoisobutyryl bromide, react at room temperature for 24h, wash with ethanol and then vacuum dry to obtain a polyolefin medical catheter with an initiator on the surface.

[0036] 3. Several polyolefin medical catheters with an initiator on the surface, with (3-acrylamidopropyl) ...

Embodiment 2

[0039] A kind of anti-drug-resistant bacteria coating is prepared on the surface of medical catheter, comprising the following steps:

[0040] 1. Soak several silicone medical catheters in Tris buffer solution containing dopamine. React at 37°C for 24h, then wash with distilled water and dry in vacuum. The concentration of the Tris buffer solution is 4 mg / ml, the pH of the Tris buffer solution is 8.4, and the surface amination-modified silicone medical catheter is obtained.

[0041]2. Put several medical catheters made of silica gel modified by surface amination into ethyl acetate solvent, the volume of ethyl acetate is 20ml, then add 0.05g / ml 4-dimethylaminopyridine, 0.08g / ml triethylamine, 0.2 g / ml bromoisobutyryl bromide, react at room temperature for 24 hours, wash with ethanol, and then vacuum-dry to obtain a silicone-based medical catheter with an initiator on its surface.

[0042] 3. Several polysilica gel medical catheters with an initiator on the surface, using dime...

Embodiment 3

[0045] A kind of anti-drug-resistant bacteria coating is prepared on the surface of medical catheter, comprising the following steps:

[0046] 1. Soak several polyvinyl chloride medical catheters in Tris buffer solution containing dopamine, react at 37°C for 24 hours, then wash with distilled water and dry in vacuum. The concentration of the Tris buffer solution is 4 mg / ml, the pH of the Tris buffer solution is 8.4, and the surface amination-modified silicone medical catheter is obtained.

[0047] 2. Put several medical catheters made of silica gel modified by surface amination into ethyl acetate solvent, the volume of ethyl acetate is 20ml, then add 0.05g / ml 4-dimethylaminopyridine, 0.08g / ml triethylamine, 0.2 g / ml bromoisobutyryl bromide, react at room temperature for 24 hours, wash with ethanol, and then vacuum-dry to obtain a silicone-based medical catheter with an initiator on its surface.

[0048] 3. There are several polysilica gel medical catheters with an initiator o...

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Abstract

The invention relates to the medical material field, in particular to a method for preparation of a coating against drug-resistant bacteria on a medical catheter surface. The method for preparation ofthe coating against drug-resistant bacteria on a medical catheter surface includes the steps of: pretreating the medical catheter surface; immobilizing an initiator on the pretreated medical cathetersurface; grafting a positively charged organic small molecule or a positively charged polymer as the monomer on the medical catheter surface, taking methacrylate polyethylene glycol as the cross-linking agent, adopting a surface initiated-supplement reduced atom transfer radical chemical grafting method to finally obtain a polycation layer antibacterial coating. The coating obtained by the methodprovided by the invention has the advantages of uniform grafting, excellent anti-infection performance, and an anti-infection rate to drug-resistant bacteria of 99% or more.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a method for preparing an anti-drug resistant bacteria coating on the surface of a medical catheter. Background technique [0002] Medical catheters are common clinical polymer medical devices that need to be in contact with human tissues. However, during this process, bacteria can easily invade through various channels, form biofilms, and cause infections, resulting in greatly increased morbidity and mortality. The average hospital stay of patients is prolonged, and the pain and medical costs suffered by patients are also rising. According to statistics, among every 5 million patients using medical catheters in China, up to 5% of them are infected by bacteria from the medical catheter itself. In this context, medical antibacterial medical catheters with antibacterial function have emerged as the times require. [0003] At present, with the abuse of antibiotics, the types of dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/14
CPCA61L29/085A61L29/14A61L2400/18A61L2420/02C08L79/02
Inventor 周超
Owner 周超
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