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After-sun repair gel containing cell growth factors and preparation method thereof

A growth factor and post-sun repair technology, applied in the field of post-sun repair gel and its preparation, can solve the problems of skin being easily damaged by ultraviolet rays, insignificant after-sun repair effect, insignificant skin repair effect, etc. content, reduced composure, mild effect

Active Publication Date: 2018-06-22
GUANGDONG COOWAY BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing after-sun repair products are mainly hydrating and moisturizing, and the effect of promoting skin repair after sun is not obvious
Chinese patent application CN 102846514A discloses an aqueous gel containing tea polyphenols for post-sun repairing, which consists of β-glucan, tea polyphenols, comfrey root extract, witch hazel extract, trehalose, Consists of thickener, humectant, preservative, chelating agent, nutrient, neutralizer, essence and deionized water, etc. It has a good moisturizing effect and can relieve skin redness and pain after sunburn. It can be used for primary The after-sun repair of sunburn has a certain effect of promoting skin repair, but the after-sun repair effect for secondary sunburn is not obvious, the skin recovery is slow, and it has no protective effect on the skin after sunburn after use, and scales and blisters form After the scab falls off, the skin is more susceptible to UV damage

Method used

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  • After-sun repair gel containing cell growth factors and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 deep-sea fish skin collagen enzymatic hydrolyzate

[0033] Including the following steps:

[0034] Take the deep-sea fish skin collagen powder, add water according to the solid-liquid ratio of 30g / L, add 0.02% of the weight of the deep-sea fish skin collagen powder hydrolyzed cod skin protein, stir for 30min, add the compound protease of 8% of the total weight of the solution, Enzymolysis at 50°C and pH value of 6.2 for 8 hours, inactivation of enzyme at 100°C for 6 minutes after the end of the enzymolysis, filtration, concentration of the filtrate under reduced pressure, and drying to obtain enzymatic hydrolyzate of deep-sea fish skin collagen; wherein, the complex protease It is composed of collagenase and bromelain in a weight ratio of 8:1.

Embodiment 2

[0035] The preparation of embodiment 2 peanut bud extract

[0036] Including the following steps:

[0037] Select the peanuts produced in the year with full seeds, sterilize the peanuts with 10% hydrogen peroxide, soak the seeds in warm water at 20°C for 12 hours, and then germinate them in a dark environment at a temperature of 20-25°C. 1. Peanut buds with a root length of 0.2-1.5 cm, remove the seed coat and homogenize, add water 20 times the weight of the peanut buds, extract twice by ultrasonic at a temperature of 50°C, each time for 40 minutes, filter, and combine the filtrates , the filtrate was concentrated under reduced pressure to 30% of the original volume, added ethanol until the alcohol content was 80%, stood still at a temperature of 4°C for 10 hours, filtered, the filtrate was concentrated under reduced pressure, and dried to obtain peanut bud extract.

Embodiment 3

[0038] The preparation of embodiment 3 cell growth factor composite liposomes

[0039] In this embodiment, the cell growth factor complex liposome includes the following components in parts by weight: 0.005 part of recombinant human basic fibroblast growth factor, 0.001 part of recombinant human vascular endothelial cell growth factor, and the liposome obtained in Example 1. 7 parts of deep-sea fish skin collagen enzymatic hydrolyzate, 5 parts of peanut bud extract prepared in Example 2, 100 parts of hydrogenated lecithin, 2 parts of sodium cholate and 25 parts of cholesterol.

[0040] The preparation method comprises the following steps:

[0041] 1) Take hydrogenated lecithin, sodium cholate and cholesterol, add them into absolute ethanol at a solid-to-liquid ratio of 3 mg / mL, stir and dissolve to obtain solution I;

[0042] 2) Take recombinant human basic fibroblast growth factor, recombinant human vascular endothelial growth factor, deep-sea fish skin collagen hydrolyzate ...

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Abstract

The invention belongs to the technical field of cosmetics, and relates to after-sun repair gel containing cell growth factors and a preparation method thereof. The after-sun repair gel containing cellgrowth factors is prepared from the following ingredients including cell growth factor composite lipidosome, rose fruit oil, phytic acid, herba menthae extracts, eucheuma extracts, Carbomer 940, polyglutamic acid, allantoin, propanediol, PEG-40 hydrogenated castor oil, tocopheryl acetate, bisabolol, preservatives, essence and deionized water. The after-sun repair gel containing the cell growth factors provided by the invention has the advantages that the formula is reasonable; the properties are stable; through the cooperated effect of all ingredients, the activity of the cell growth factorscan be effectively maintained; the bioavailability of the cell growth factor is improved; the water supplementation and moisture preservation effect is obvious; the effects of obviously relieving symptoms of skin erythema diffusum, red tumidness, decrustation, blisters and the like caused by sun injury and accelerating the after-sun skin restoration are achieved; meanwhile, the goal of relieving the skin blackening due to pigment decomposition can be achieved.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and relates to an after-sun repair gel containing cell growth factors and a preparation method thereof. Background technique [0002] Long-wave ultraviolet UVA can penetrate the skin epidermis and most of the dermis, oxidize the reduced melanin in the epidermis and directly tan the skin, long-term action will destroy the elastic fibers in the skin, cause skin photoaging, and cause serious damage to the skin damage. Medium-wave ultraviolet UVB has a weaker effect on the skin than UVA. Most of it is absorbed by the epidermis, and a small amount penetrates the epidermis, which can denature the nucleic acid or protein in the epidermal cells of the skin, causing acute dermatitis, erythema or burns. [0003] Sunburn is caused by excessive exposure of the skin to ultraviolet rays. The symptoms and signs generally appear within 1 to 24 hours after sunburn. Skin changes range from mild erythema with tr...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/34A61K8/49A61K8/55A61K8/64A61K8/67A61K8/81A61K8/88A61K8/92A61Q19/00
CPCA61K8/34A61K8/345A61K8/4946A61K8/55A61K8/64A61K8/678A61K8/8147A61K8/88A61K8/922A61K8/97A61K2800/524A61K2800/5922A61Q19/00A61Q19/004
Inventor 陈松彬倪彦艳刘杰森陈健欢郑涌镟
Owner GUANGDONG COOWAY BIOTECH CO LTD
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