39results about How to "Promote cell division" patented technology

The present invention discloses an immunotherapeutic method for treating patients suffering from colon cancer, by administering expanded tumour-reactive CD4+ helper and / or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a tumour in the colon or a metastasis arising from a tumour in the colon. The present invention provides a new effective method for treating colon cancer and metastatic colon cancer, without adverse side effects associated with the known treatments. The method comprises identification of in a patient one or more sentinel and / or metinel lymph nodes draining a tumour in the colon or a metastasis from a tumour in the colon, resection of the one or more nodes and, optionally all or part of the tumour or metastasis, isolation of tumour-reactive T-lymphocytes from said lymph nodes, in vitro expansion of said tumour-reactive T-lymphocytes, and administration of the thus obtained tumour-reactive T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+ helper and / or CD8+ T-lymphocytes.

The present invention relates to a combination therapy method for treating gastrin-dependent tumors. The method comprises the immunization of a patient with an anti-gastrin 17 immunogenic composition in combination with the administration of chemotherapeutic agents such as 5-fluorouracil and leucovorin.

The present invention discloses an immunotherapeutic method for treating patients suffering from malignant melanoma, by administering expanded tumour-reactive CD4+ helper and / or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a malignant melanoma or a metastasis arising from malignant melanoma. The present invention provides a new effective method for treating malignant melanoma and metastatic malignant melanoma, without adverse side effects associated with the known treatments. The method comprises identification of in a patient one or more sentinel and / or metinel lymph nodes draining a malignant melanoma or a metastasis there from, resection of the one or more nodes and, optionally all or part of the tumour or metastasis, isolation of tumour-reactive T-lymphocytes from said lymph nodes, in vitro expansion of said tumour-reactive T-lymphocytes, and administration of the thus obtained tumour-reactive T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+ helper and / or CD8+ T-lymphocytes.

The present invention discloses an immunotherapeutic method for treating a patient suffering from urinary bladder cancer by administering expanded tumour-reactive CD4+ helper and / or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a tumour in the bladder or a metastasis arising from a tumour in the bladder. The method provides a new effective method for treating urinary bladder cancer and metastatic bladder cancer, without adverse side effects associated with the known treatments. The method comprises identification of in a patient one or more sentinel and / or metinel lymph nodes draining a tumour in the bladder or a metastasis from a tumour in the bladder, resection of the one or more nodes and, optionally all or part of the tumour or metastasis, isolation of tumour-reactive T-lymphocytes from said lymph nodes, in vitro expansion of said tumour-reactive T-lymphocytes, and administration of the thus obtained tumour-reactive T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+ helper and / or CD8+ T-lymphocytes.

A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber

A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber

The invention relates to a saline-alkali soil improving agent and its preparation method. The preparation method comprises the following steps: mixing Rhodopseudomonas palustris, Pichia membranefaciens Hansen bacterium, lactobacillus casei, Staestomyces microflavus and seaweed slurry, organically combining a plurality of beneficial microorganisms and seaweed through multi-time fermentation, culturing in a compound mode to obtain a novel microorganism agent-seaweed bio-fungus. adding a proper amount of humic acid, organic matter, active zeolite powder and molasses, and fermenting and drying the fermented product. The biology saline-alkali soil improving agent uses a plurality of microorganisms and employs strong effects of a unique ionic adsorbent, an organic neutralization balancing agent, an ion-exchange agent and a beneficial bacteria conversion starter to achieve the purposes of improving the soil environment, regulating acid-base balance, reducing the salt content, effectively raising the soil fertility and permeability, loosening the soil, eliminating the soil hardening, degrading the harmful substance and promoting the accumulation and conversion of the organic substance.

There are provided compositions and methods for modulating stem cell division decisions, in particular, division symmetry. It has been demonstrated that wnt7a acts through frizzled-7 receptor expressed on the surface of adult stem cells, e.g. satellite stem cells, to activate the planar cell polarity (PCP) pathway, thereby promoting symmetrical expansion of stem cells. The compositions and methods of the invention are useful, for example, in modulating stem cell division symmetry in vitro and in vivo, in replenishing and expanding the stem cell pool, and in promoting the formation, maintenance, repair and regeneration of tissue.

The invention discloses a method for promoting maturation of ottelia acuminate seeds. The method includes the step that hardened and incompletely-mature ottelia acuminate seeds with white seed coats are adopted and cultured in first accelerant liquid and second accelerant liquid till the seeds are completely mature. The defect that mature ottelia-acuminate seeds are difficult to collect is overcome. As ZT and IAA in the first accelerant liquid have the effect of promoting cell division of immature seeds, and DMSO has quite high permeability, the ZT and the IAA can permeate into cells and directly act on embryos and albuminous cells, and the embryos and endosperm of the immature seeds are perfectly developed. As GA3 and 6-BA in the second accelerant liquid have the effect of promoting cell division, the seeds can be mature; meanwhile, the GA3 and the 6-BA in the second accelerant liquid have the effects of promoting conversion of starch in the endosperm into soluble saccharide and seed germination. The method is easy to operate and low in production cost; a large number of mature ottelia acuminate seeds can be obtained in a short time, mass seedling breeding is carried out, and high quality seedlings are provided for artificial cultivation of ottelia acuminate.

The invention mainly relates to the technical field of hybrid planting of traditional Chinese medicines, and discloses a low-altitude hybrid planting method for eucommia ulmoides and polygonatum kingianum. The low-altitude hybrid planting method for eucommia ulmoides and polygonatum kingianum comprises the steps of soil preparation, eucommia ulmoides planting, eucommia ulmoides management, polygonatum kingianum planting, polygonatum kingianum management and harvesting treatment. The method is simple, a large amount of soil, labors and materials are saved, growth of the eucommia ulmoides and the polygonatum kingianum is promoted, the eucommia ulmoides can be peeled off 7-8 years after being planted, the yield can reach 627 kg / mu, the polygonatum kingianum reproduced by rhizomes can be harvested 1 year after being planted, the polygonatum kingianum reproduced by seeds can be harvested 2 years after being planted, the yield reaches 583 kg / mu, a new method is provided for planting of the eucommia ulmoides and the polygonatum kingianum in Anhui area, and the planting cost is saved by 39.4%; and the eucommia ulmoides and the polygonatum kingianum are planted in a low-altitude region, theeucommia ulmoides and the polygonatum kingianum which adapt to a low-altitude environment can be gradually selected out, the planting difficulty is reduced, and the planting cost is saved.