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Surgical instrument two-cavity multienzyme coagulated bead and preparation method thereof

A technique for surgical instruments and coagulation beads, which is applied in the field of surgical instrument two-cavity multi-enzyme coagulation beads and its preparation, can solve the problems of decreased enzyme activity stability and cleaning power of cleaning agents, etc., and achieves the goal of maintaining enzyme activity and being easy to use Effect

Inactive Publication Date: 2018-06-22
NANJING JUSHA DISPLAY TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At the same time, the current multi-enzyme cleaning has the problem that the stability of the enzyme activity will decrease, that is, with the passage of time, the enzyme activity will gradually decrease, resulting in a decrease in the cleaning power of the cleaning agent. This is also a problem that plagues the medical cleaning industry.

Method used

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  • Surgical instrument two-cavity multienzyme coagulated bead and preparation method thereof
  • Surgical instrument two-cavity multienzyme coagulated bead and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: The structure of the two-chamber multi-enzyme coagulation beads for surgical instruments and instructions for use

[0034] The two-chamber multi-enzyme coagulation bead of the surgical instrument uses a water-soluble polymer film as a coating material to make a coagulation bead with two chambers. The two-chamber beads contain solid enzyme in one chamber and anhydrous ultra-concentrated cleaning agent in the other chamber. The polymer film is preferably one or both of polyvinyl alcohol, polyvinylpyrrolidone and cellulose;

[0035] The ultra-concentrated cleaning agent is composed of the following components and the mass percentages of each component are:

[0036] Nonionic surfactant: 30%~80%

[0037] Amphoteric surfactant: 2%~10%

[0038] Corrosion inhibitor: 2%~15%

[0039] Chelating agent: 0.1%~2%

[0040] Fungicide: 1%~10%

[0041] Solvent balance

[0042] The total is 100%.

[0043] The non-surfactant is two or more of fatty alcohol polyoxyethylene...

Embodiment 2

[0055] Example 2 Preparation method of two-chamber multi-enzyme beads for surgical instruments

[0056] The ultra-concentrated cleaning agent is composed of the following components and the mass percentages of each component are:

[0057] AEO-9: 80%

[0058] Crodateric PI: 2%

[0059] Crodacor BE: 2%

[0060] Glutamate diacetate tetrasodium salt: 2%

[0061] Casson: 1%

[0062] polyethylene glycol balance

[0063] The total is 100%.

[0064] Add part of polyethylene glycol into the stirred tank according to the formula proportion, turn on the stirrer, first add 2% amphoteric surfactant imidazoline amphoteric surfactant Crodateric PI, then add 2% chelating agent glutamic acid diacetic acid tetrasodium salt to dissolve After the dissolution is completed, add 80% nonionic surfactant fatty alcohol polyoxyethylene ether AEO-9, 1% fungicide Cassone, 2% corrosion inhibitor organic borate Crodacor BE, and then add the remaining amount of solvent polyethylene alcohol, and then s...

Embodiment 3

[0080] The two-chamber multi-enzyme beads of the above surgical instruments and the traditional liquid multi-enzyme cleaning agent on the market were evaluated in the protease activity, and the results are shown in the following table.

[0081]

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Abstract

The invention discloses a surgical instrument two-cavity multienzyme coagulated bead. The multienzyme coagulated bead uses a water-soluble macromolecular film as a coating material for forming the coagulated bead with two cavities; the two cavities comprise a cavity 1 and a cavity 2; solid enzymes are put into the cavity 1; super concentrated cleaning agents are put in the cavity 2, and include nonionic surfactants, ampholytic surfactants, corrosion inhibitors, chelating agents, sterilizing agents and solvents; the solid enzymes consist of protease, lipase, amylase and cellulase. The surgicalinstrument two-cavity multienzyme coagulated bead has the advantages that the cleaning capability is high; the enzyme activity stability is high; safety and toxicity are realized; the surgical instrument two-cavity multienzyme coagulated bead is applicable to medical appliance cleaning.

Description

technical field [0001] The invention belongs to the field of medical instruments, and in particular relates to a two-chamber multi-enzyme coagulation bead of a surgical instrument and a preparation method thereof. Background technique [0002] To prevent and control infection in hospitals, surgical instruments need to be cleaned according to standard and strict procedures. This is the most important part of sterilization before sterilization and reprocessing of medical equipment. The protection of supply center staff from cross-infection also plays an important role in improving the effectiveness of hospital surgical instrument sterilization [0003] Cleaning of surgical instruments needs to be carried out in strict accordance with the process, and the operation steps are rinsing, washing, rinsing, secondary rinsing with pure water, lubricating and drying. Generally speaking, in most cases, complex instruments must be dismantled and cleaned manually, and sometimes ultrasoni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D1/94C11D3/386C11D3/37C11D3/36C11D3/33C11D3/28C11D3/20C11D3/43C11D3/48C11D3/60C11D17/00A61B90/70
CPCC11D1/94A61B90/70C11D1/008C11D1/72C11D1/88C11D3/2044C11D3/28C11D3/33C11D3/361C11D3/3707C11D3/38609C11D3/38627C11D3/38645C11D3/43C11D3/48C11D17/003
Inventor 王卫施君君
Owner NANJING JUSHA DISPLAY TECH
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