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Film, manufacturing method thereof, and use thereof

A film and polymer technology, used in applications, pharmaceutical formulations, medical science, etc., can solve problems such as leakage, rigid surgical mesh material, and secondary infection at sutures.

Pending Publication Date: 2018-06-29
IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to its hard material and poor tissue adaptability, the surgical mesh is not easy to fit tightly with soft tissue, so it needs to be fixed by sutures, which makes the operation inconvenient
In addition, currently commercially available surgical mesh equipment for automatic fixation, such as nails, concealed buckles, etc., under normal circumstances, sutures are still required, so secondary infection and leakage are prone to occur at the sutures

Method used

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  • Film, manufacturing method thereof, and use thereof
  • Film, manufacturing method thereof, and use thereof
  • Film, manufacturing method thereof, and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0160] A. Film preparation

[0161] 1. Comparative example

Embodiment 1

[0169] Embodiment 1: the preparation of polycaprolactone / poly(lactic-co-glycolic acid) / alginate (PCL / PLGA / AA) film

Embodiment 1-1

[0170] Example 1-1: Preparation of a film whose weight ratio of (polycaprolactone / polylactic acid-glycolic acid copolymer) to alginate is 1:0.0625

[0171] 1. Add 3.2±0.05g of polycaprolactone (Mw.120K) to 10ml of dichloromethane (DCM), and mix at a speed of 50rpm for 3 hours to complete the preparation of the polycaprolactone solution.

[0172] 2. Add 0.8±0.05g of polylactic acid-glycolic acid copolymer (PLGA) (Mw.240K) to 10ml of dichloromethane (DCM), and then mix at a speed of 50rpm for 3 hours to complete the polylactic acid-glycolic acid copolymerization Solution preparation.

[0173] 3. Mix the polycaprolactone solution and the poly(lactic-co-glycolic acid) solution evenly to form a mixed solution.

[0174] 4. Add 0.25 g of alginate (AA) to the above mixed solution to form a mixture and keep stirring.

[0175] 5. After stirring for about 1 minute ± 10 seconds, pour the above mixture on a Teflon plate, and use a 300 μm scraper to scrape it, and then let it stand overni...

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Abstract

The present disclosure provides a film composed of a polymer mixture, wherein the polymer mixture includes: a hydrophobic composition including polycaprolactone (PCL); and at least one hydrophilic polymer selected from a group consisting of: alginate, gelatin, chitosan, hyaluronic acid, collagen, demineralized bone matrix (DSM), carboxymethyl cellulose (CMC), fibrin, polyoxyethylene, polyethyleneglycol (PEG) and polyvinylpyrrolidone, wherein the weight ratio of the hydrophobic composition to the at least one hydrophilic polymer is about 1:0.01-100, and wherein the film has the effect of preventing leakage from a surgical wound or a diffuse wound.

Description

technical field [0001] The invention relates to a thin film and its manufacturing method and application. Background technique [0002] Tissue adhesives and sealants have many potential medical applications, such as closing wounds, supplementing or replacing sutures or staples in surgical procedures inside the body, preventing leakage of fluids such as blood, bile, gastrointestinal and cerebrospinal fluid, or It is used to fix surgical mesh on soft tissue, etc. Among the adhesives, fibrin is the most widely used. However, fibrin has the disadvantages of slow curing and poor mechanical strength. In addition, the use of fibrin has the risk of virus infection, and the wound is prone to tissue sticking. , so its use in surgery is limited. [0003] In cardiovascular surgery or liver, gallbladder, intestine, and gastrectomy, surgical mesh or sutures are mostly used to complete the surgical site reinforcement, but the materials currently used are prone to foreign body inflammatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/08A61L24/10A61L24/04
CPCA61L24/046A61L24/06A61L24/08A61L24/104A61L2400/04C08L67/04C08L5/04C08L5/08C08L29/04A61L24/043Y02P20/141
Inventor 张惟闳杨明嘉林芸含郭昆茂王羽淇沈欣欣林立杰
Owner IND TECH RES INST