Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of isocorynoxeine to preparation of medicines with neuroprotective effect

A technology of isodehydromenthomenine and neuroprotection, applied in the field of natural medicinal chemistry, to achieve the effects of slowing down the heart rate, saving toxic effects and good protective effects

Inactive Publication Date: 2018-07-06
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research and report on the effect of isodehydrorhynchophylline on monoamine oxidase

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of isocorynoxeine to preparation of medicines with neuroprotective effect
  • Application of isocorynoxeine to preparation of medicines with neuroprotective effect
  • Application of isocorynoxeine to preparation of medicines with neuroprotective effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This example verifies the neuroprotective effect of isodehydrorhynchophylline through the following experimental steps

[0034] Dopaminergic neuron-specific toxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) 40 μg / ml treated zebrafish embryos 1-3 days after fertilization, 20 μg / mL Deprenyl was used as a positive control, 20 μM isodehydrorhynchophylline (indicated by Z3) was added, and the dopaminergic neuron-specific marker gene dat was used as a probe for in situ hybridization to determine the results.

[0035] The result is as figure 1 (control group), figure 2 (MPTP group), image 3 (benzylmethynylamine group and MPTP mixed group) and Figure 4 (mixed group of isodehydrorhynchophylline Z3 and MPTP). From the comparison in the figures, it can be concluded that Z3 can effectively reverse the death of dopaminergic neurons induced by MPTP. It is generally believed that Parkinson's disease is caused by the death of dopaminergic neurons, and dat is the marker ...

Embodiment 2

[0037] In this example, the following experiments were performed to detect dopaminergic neurons by in situ hybridization with dat probes, and the changes in the number of dopaminergic neurons before and after dosing were observed in zebrafish embryos 3 days after fertilization.

[0038] A, adding 0.1% PTU to the embryos of the control group to remove the pigment;

[0039] B, MPTP treatment of embryos for 48 hours;

[0040] C, adding the positive control drug Deprenyl and MPTP to co-treat the embryo for 48 hours;

[0041] D. Embryos treated with MPTP and Z3.

[0042] According to the experiment, the normal expression of diencephalic dopaminergic neurons in group A; the death of a large number of diencephalic dopaminergic neurons in group B; the increase of dopaminergic neurons in group C compared with group B; Both elements have recovered significantly, and the Z3's protection is even better.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides application of isocorynoxeine to preparation of medicines with a neuroprotective effect. The medicines with the neuroprotective effect, provided by the invention, can effectively rescue the toxic effect of neurotoxin MPTP on dopaminergic neurons and have a protective effect on the dopaminergic neurons; compared with the common effects of lowering the blood pressure, expanding blood vessels and slowing the heart rate of the isocorynoxeine, the invention develops novel application of the isocorynoxeine, and a theoretical basis and an experimental basis are provided for further studying the neuropharmacology of a Chinese medicinal herb uncaria; furthermore, the isocorynoxeine provides a new idea and possibility for development of a Parkinson's disease treating medicine,an antidepressant medicine and an Alzheimer's disease treating medicine; especially, as the Parkinson's disease treating medicine, the isocorynoxeine has a particularly outstanding effect.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry and relates to the application of isodehydrorhynchophylline in the preparation of medicines with neuroprotective effect. Background technique [0002] Uncaria is an evergreen vine of the Rubiaceae Uncaria genus, a climbing shrub, with square columnar stems and branches that are slender and hairless, papery leaves that are oval, and flower heads. Uncaria is used as medicine with hooked stems and branches. It has the functions of clearing away heat, calming the liver, relieving wind and relieving convulsions. Modern pharmacological experiments have also proved that Uncaria has antihypertensive effect, so it has high medicinal value. Previous studies have shown that Uncaria decoction, ethanol extract, total alkaloids and rhynchophylline, no matter to anesthetized animals or non-anesthetized animals, normal animals or hypertensive animals, and regardless of intravenous injection or intragast...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/438A61P25/00A61P25/16A61P25/24A61P25/18
CPCA61K31/438
Inventor 杨选军仲寒冰
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com