Diabetes vaccine based on (M)T-DC (Target-dendritic cell) technology

Abstract

The invention relates to diabetes vaccine based on a (M)T-DC (Target-dendritic cell) technology. The vaccine is a dendritic cell preparation obtained by using specific single-epitope multiple antigenpeptides for in-vitro sensitization of dendritic cell and is venous re-transfusion type diabetes vaccine. Removal of a vascular endothelial infection factor is interfered by the (M)T-DC technology, the vaccine can penetrate into the local lesion in a targeted way, corresponding treatment courses of mesenchymal stem cell treatment with multidirectional differentiation potential is also adopted, soas to repair blood vessel endothelium, cicatrix is dissolved, a pancreatic intra-tissue repairing is realized, a pancreatic immune system is repaired and the insulin beta cell function is recovered, so that the treatment aim of enabling insulin secretion to be normal is fulfilled.

Description

technical field [0001] The invention relates to a vaccine, in particular to a diabetes vaccine based on (M)T-DC technology. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to defects in insulin secretion or insulin β-cell action. Sustained high blood sugar and long-term metabolic disorders can lead to damage, dysfunction and failure of tissues and organs throughout the body, especially the eyes, kidneys, cardiovascular and nervous systems. Severe cases can cause acute complications such as dehydration, electrolyte disturbance and acid-base imbalance, ketoacidosis and hyperosmolar coma. Drugs and diet are used in treatment, but it is difficult to achieve the desired effect. [0003] According to research, cytotoxin-associated protein (CagA), vacuolar toxin-associated protein (VacA), urease (Ure), cytomegalovirus (CMV), human papillomavirus (HPV-16), human papillomavirus (HPV- 18), herpes simplex virus-II (HSV-II), C...

AI Technical Summary

Problems solved by technology

Long-term low-virulence infection will cause the immune system to gradually adapt to this infection. In the case of low immunity, the corresponding immune response cannot be caused against it, resulting in immune tolerance. The body cannot recognize the relevant pathogenic microorganisms, which will lead to pathogenic microorganisms. Long-term persistent infection, causing long-term damage to the body

[0004] This type of infection will cause serious pathological damage to the cardiovascular and cerebrovascular, and the continuous damage of vascular endothelial cells will cause diseases of the vascular system; the destruction of the vascular endothelium will form microthrombi, and the formation of microthrombi will block capillaries, resulting in the slow function of vascular cells. Regression, the progressive damage of blood vessels slowly accumulates, from quantitative deformation to qualitative change, once a breakthrough occurs, the damage to organ function is irreversible; it will lead to a decline in the function of the blood supply system, and damage to blood vessel function will lead to the occurrence of diseases such as diabetes

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