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Preparation method of agar/polyacrylamide dihydrogen bond cooperative crosslinking high-tenacity hydrogel capable of 3D printing

A polyacrylamide, 3D printing technology, applied in the direction of additive processing, etc., can solve the problems of hydrogel preparation and molding process limitations, inability to apply hydrogels, difficult to control synthesis, etc., to achieve a short preparation cycle, ensure uniformity, The effect of low production cost

Active Publication Date: 2018-07-13
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the introduced hydrophobic association, it is difficult to separate the hydrophilic phase and the lipophilic phase, relying on high-speed stirring, the synthesis is difficult to control, and the preparation and molding process of the hydrogel is greatly limited. Free-form methods that do not affect the biocompatibility of the hydrogel are not suitable for this type of hydrogel
Therefore, the application of this hydrogel in the fields of tissue engineering, drug screening, and organs on a chip is limited.

Method used

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  • Preparation method of agar/polyacrylamide dihydrogen bond cooperative crosslinking high-tenacity hydrogel capable of 3D printing
  • Preparation method of agar/polyacrylamide dihydrogen bond cooperative crosslinking high-tenacity hydrogel capable of 3D printing
  • Preparation method of agar/polyacrylamide dihydrogen bond cooperative crosslinking high-tenacity hydrogel capable of 3D printing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Step 1): Weigh 0.2g of agar (Agar) into 8mL of deionized water, stir at 75°C and 500RPM at high speed for 20min to dissolve to obtain a transparent aqueous solution.

[0034]Step 2): Weigh 3.554g AM and 0.0074g KA respectively, add to 2mL and stir to dissolve to obtain a uniform transparent aqueous solution. Stir this solution in the solution of step 1) at 50°C and 500RPM for 5min in a dark environment to prepare a mixed solution with 0.06536mol / L Agar, 5mol / L AM and 0.005mol / L KA.

[0035] Step 3): Inject the mixed solution obtained in step 2) into a glass mold under light-shielding conditions, and place the glass mold under ultraviolet light for 5-7 hours to obtain a strong double hydrogen bond synergistically cross-linked and high-toughness Agar / PAM Hydrogels.

[0036] Experiments show that the tensile strength of the double hydrogen bond synergistically cross-linked Agar / PAM hydrogel material obtained in this example is 0.449 MPa, and the elongation at break is 658...

Embodiment 2

[0038] Step 1): Weigh 0.2g of agar (Agar) into 8mL of deionized water, stir at 75°C and 500RPM at high speed for 20min to dissolve to obtain a transparent aqueous solution.

[0039] Step 2): Weigh 4.9756g AM and 0.0103g KA respectively, add to 2mL and stir to dissolve to obtain a uniform transparent aqueous solution. Stir this solution in the solution of step 1) at 50°C and 500RPM for 5min in a light-proof environment to prepare a mixed solution with 0.06536 mol / L Agar, 7 mol / L AM and 0.007 mol / L KA.

[0040] Step 3): Inject the mixed solution obtained in step 2) into a glass mold under light-shielding conditions, and place the glass mold under ultraviolet light for 5-7 hours to obtain a strong double hydrogen bond synergistically cross-linked and high-toughness Agar / PAM Hydrogels.

[0041] Experiments show that the tensile strength of the double hydrogen bond synergistically cross-linked Agar / PAM hydrogel material obtained in this example is 0.490 MPa, and the elongation at ...

Embodiment 3

[0043] Step 1): Weigh 0.2g of agar (Agar) into 8mL of deionized water, stir at 75°C and 500RPM at high speed for 20min to dissolve to obtain a transparent aqueous solution.

[0044] Step 2): Weigh 6.3972g AM and 0.0132g KA respectively, add to 2mL and stir to dissolve to obtain a uniform transparent aqueous solution. Stir this solution in the solution of step 1) at 50°C and 500RPM for 5min in a dark environment to prepare a mixed solution with 0.06536mol / L Agar, 9mol / L AM and 0.009mol / L KA.

[0045] Step 3): Inject the mixed solution obtained in step 2) into a glass mold under light-shielding conditions, and place the glass mold under ultraviolet light for 5-7 hours to obtain a strong double hydrogen bond synergistically cross-linked and high-toughness Agar / PAM Hydrogels.

[0046] Experiments show that the double hydrogen bond synergistically cross-linked Agar / PAM hydrogel material obtained in this example has a tensile strength of 0.500 MPa and an elongation at break of 4631...

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Abstract

The invention discloses a preparation method of an agar / polyacrylamide dihydrogen bond cooperative crosslinking high-tenacity hydrogel capable of 3D printing. The preparation method comprises the following steps: firstly dissolving agar into deionized water under heating and stirring conditions to obtain a uniform water solution, then adding a mixed solution of acrylamide and a light initiator dissolved into deionized water into a water solution of agar for uniform mixing, pre-forming the final mixed solution in a mold or 3D printing manner, firstly cross-linking agar at a low temperature, then putting the cross-linked agar under an ultraviolet lamp so that acrylamide is polymerized and hydrogen bonds are cross-linked, and the dihydrogen bond cooperative crosslinking high-tenacity hydrogelis formed; due to the fact that the hydrogel contains natural high molecular agar, and the viscosity is regulated and controlled by adding a small amount of fumed silica under the state of sol, the hydrogel has good sagging resistance and rapid gelatinization characteristics, and 3D printing can be realized.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a method for preparing a 3D-printable agar / polyacrylamide double hydrogen bond synergistically cross-linked high-toughness hydrogel. Background technique [0002] Hydrogel is a polymer material with a three-dimensional network structure of high water content and high porosity formed by chemical cross-linking or physical cross-linking. This characteristic is similar to that of biological soft tissue, which makes hydrogel widely used in the field of tissue engineering. potential application. Due to the high water content of hydrogels, their mechanical properties are generally poor, and chemically crosslinked hydrogels have poor tissue compatibility, which cannot meet the requirements of use. The current chemically cross-linked hydrogels still have the disadvantages of being difficult to repair after cross-linking damage and poor tissue compatibility, so the r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L33/26C08L5/12C08F120/56C08F2/48C08K3/36B33Y70/00
CPCB33Y70/00C08F2/48C08F120/56C08J3/075C08J2333/26C08J2405/12C08K3/36
Inventor 李学锋王慧张高文龙世军舒萌萌张奕坤邱迪
Owner HUBEI UNIV OF TECH
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