A gradient bioceramic material coated with gelatin/chitosan composite porous membrane and its preparation method
A bioceramic material and bioceramic technology, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problems of high brittleness of CPP, slow degradation speed, and unsatisfactory bone repair, and achieve simple preparation method, strong practicability, Effects that are easy to scale
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Embodiment 1
[0039] 1) Preparation of porous bioceramics
[0040] The ceramic raw material is calcium dihydrogen phosphate, and the porogen used is stearic acid. The binder is polyvinyl alcohol (5% PVA) and is sintered in a box furnace, using an alumina crucible. The ceramic sintering process is divided into two steps. The pre-sintering process is to pour the calcium dihydrogen phosphate powder into the crucible, raise the temperature to 500°C at 5°C / min, keep it for 10h, and take it out after cooling to room temperature with the furnace. Roughly grind with a mortar and thoroughly mix with the binder polyvinyl alcohol according to the mass ratio of 5%, pour it into a ball mill jar, add an appropriate amount of deionized water (submerged in powder), and ball mill at a speed of 230r / h for 1 hour, take out Finally, dry at 55°C in a blast drying oven, and use 200 mesh to screen out powder 1 with a particle size of <200 mesh for future use. Ball mill and screen stearic acid to obtain 50-80 me...
Embodiment 2
[0047] 1) Preparation of porous bioceramics: same as Example 1
[0048] 2) Preparation of gelatin / chitosan composite sol:
[0049] Measure 4mL of glacial acetic acid solution, dissolve it in 50mL of deionized water, and stir for 30min. Weigh 2g of chitosan powder, add it to 50mL deionized water, stir fully to disperse chitosan evenly in deionized water, add the acetic acid solution configured above drop by drop, stir for 2h to form a uniform chitosan sol, and The sol was placed at 40° C., 4 g of gelatin was added, and stirred evenly to form a composite sol in which chitosan accounted for 1 / 3 respectively.
[0050] 3) gelatin / chitosan composite sol coating: same as embodiment 1
Embodiment 3
[0052] 1) Preparation of porous bioceramics: same as Example 1
[0053] 2) Preparation of gelatin / chitosan composite sol:
[0054] Measure 4mL of glacial acetic acid solution, dissolve it in 50mL of deionized water, and stir for 30min. Weigh 4g chitosan powder, add to 50mL deionized water, fully stir to make chitosan evenly dispersed in deionized water, add the acetic acid solution configured in front drop by drop, stir for 2h to form uniform chitosan sol, the The sol was placed at 40° C., 2 g of gelatin was added, and stirred evenly to form a composite sol in which chitosan accounted for 2 / 3 respectively.
[0055] 3) gelatin / chitosan composite sol coating: same as embodiment 1
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