A kind of gold nanothorn and its preparation method and application
A gold nano-reaction technology, applied in metal processing equipment, transportation and packaging, echo/ultrasonic imaging agents, etc., can solve the problems of difficult to control nano-structure, non-single morphology, missing and so on
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[0064]The invention provides a method for preparing gold nanothorns, comprising the following preparation steps:
[0065] 1) Gold perchlorate, CTBA, sodium borohydride and water are mixed for a reduction reaction to obtain a CTBA-gold nano seed solution;
[0066] 2) mixing gold perchlorate, polymer template molecules and water to obtain a complex solution;
[0067] 3) mixing the complex solution obtained in step 2), silver nitrate, the CTBA-gold nano seed solution obtained in step 1) and water for self-assembly to obtain a self-assembled solution;
[0068] 4) mixing the self-assembled solution obtained in step 3) with ascorbic acid for a reduction reaction to obtain gold nanothorns;
[0069] The steps 1) and 2) are not in sequence;
[0070] The polymer template molecule in the step 1) is a polydentate mercapto-alternating lipoic acid-polyethylene glycol or a comb-shaped polyacrylic acid-mercapto-polyethylene glycol polymer;
[0071] The multidentate mercapto-alternating lip...
Embodiment 1
[0153] Synthesis of polymer template molecules
[0154] 1) To a mixed solution of 2-amino-2-methyl-1,3 propanediol (0.74g, 7.0mmol) and sodium borohydride (0.58g, 6.9mmol) in DMF / water (10mL / 10mL) was added dropwise with A solution of lipoic acid-NHS (1.77g, 5.8mmol) in DMF (3mL) with a structure represented by formula III, the temperature of the reaction solution was kept at about 4°C, and stirred overnight at room temperature. After the reaction mixture was filtered, it was extracted with chloroform, the combined organic phases were washed and dried, and the crude product was separated and purified by column chromatography (silica gel was the stationary phase, and dichloromethane containing 10% methanol was the mobile phase) to obtain the compound having the structure shown in formula IV. compound.
[0155] The obtained compound (0.35 g, 1.2 mmol), succinic anhydride (0.3 g, 3 mmol) and 4-dimethylaminopyridine (23 mg, 0.19 mmol) were dissolved in anhydrous pyridine (5 mL) w...
Embodiment 2
[0168] CTBA gold nano seed solution is 0.10mL, other is identical with embodiment 1.
[0169] The electron microscope scanning image of the obtained nano-golden thorn particles is as follows: figure 2 shown by figure 2 It can be seen that the nano-golden spine particles obtained in Example 2 have a single shape and a uniform particle size of 50 nm.
[0170] The absorption spectra of the obtained gold nanothorns are shown in Figure 6 Shown in curve b.
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