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Nutritional composition capable of promoting wound healing, bedsore restoration, and postoperative stress ulcer healing

A technology of stress ulcer and nutritional composition, which is applied in the field of decubitus repair, nutritional composition for postoperative stress ulcer healing, promotion of wound healing, and can solve the problem of difficult wound healing

Active Publication Date: 2018-07-31
YABAO PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] As the pace of life continues to accelerate, problems caused by diseases and stress are becoming more and more serious. How to solve stress anxiety, refractory wounds, decubitus ulcers, postoperative stress ulcers, etc. caused by stress, diseases, aging, etc. Questions are looming, especially for the perioperative population

Method used

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  • Nutritional composition capable of promoting wound healing, bedsore restoration, and postoperative stress ulcer healing
  • Nutritional composition capable of promoting wound healing, bedsore restoration, and postoperative stress ulcer healing
  • Nutritional composition capable of promoting wound healing, bedsore restoration, and postoperative stress ulcer healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: the preparation method of composition of the present invention

[0050] (1) Obtain collagen peptide: prepare collagen powder into a solution with a certain concentration, adjust the pH to 5.0-8.0, add an appropriate amount of protease hydrolysis solution, and react in a water bath at 40-60°C for 60-150min to obtain Different molecular weight collagen peptides. After the reaction is completed, inactivate in a boiling water bath, and store at low temperature for later use. Adjust the amount of enzyme added or reaction time as needed to produce collagen peptides with a molecular weight of 3000-5000 and a molecular weight of less than 1000. See the attached diagram for the molecular weight distribution. Figure 4 , 5 . Also commercially available, high molecular weight collagen peptide (high molecular weight fish collagen peptide GBB 50SP (molecular weight 2000-5000, purchased from Nitta Gelatin Co., Ltd., Japan)), low molecular weight collagen peptide (low...

Embodiment 2

[0058] Embodiment 2: the preparation method in the powder, granule, tablet, hard capsule, oral liquid and suspension of the composition of the present invention.

[0059] Powder: the ambient humidity is controlled below 40%, the temperature is 18-25°C, the raw and auxiliary materials are crushed, sieved, and weighed, and an appropriate amount of pharmaceutically acceptable auxiliary materials, the composition of Example 1, and other compounding materials are added to the mixer Raw materials and appropriate amount of pharmaceutically acceptable excipients, the mixing time is 5-30 minutes, the rotation speed is 20-30 r / min, the mixed powder is passed through a 20-40 mesh sieve, and quantitative packaging is sufficient. Moisture content <5%, and the microbial limit complies with relevant regulations.

[0060] Granules: Take the composition 8 of Example 1, and other compound raw materials and auxiliary materials in appropriate amounts. Mixing, spraying and other wet granulation, ...

Embodiment 3

[0065] Example 3: In the composition of the present invention, the composition of different ratios of high and low molecular weight collagen peptides and wheat peptides affects the body's absorption and metabolism rate.

[0066]Collagen peptide in the composition of this example: wheat peptide: casein hydrolyzate: gorse frondosa = 2.5: 2.2: 0.075: 0.

[0067] Rats were used to study the oral intake of different proportions of high and low molecular weight collagen peptides and wheat peptide compositions. Based on the time-varying curves of hydroxyproline and glutamine concentrations in plasma, the body’s response to high and low molecular weight collagen peptides was quantitatively analyzed. , The rate of absorption and metabolism of the active ingredients in wheat peptide, and optimize the optimal combination ratio. The characteristic substance in collagen peptide is hydroxyproline (Hyp), and the characteristic substance in wheat peptide is glutamine (Gln). A large number of...

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Abstract

The invention provides a nutritional composition capable of promoting wound healing, bedsore restoration, and postoperative stress ulcer healing. The nutritional composition is capable of shortening the length of stay of patients at the perioperative period, reducing medical cost, and reducing mortality. The nutritional composition is prepared via combination of collagen peptide, wheat peptide, and casein hydrolysate at a certain ratio.

Description

technical field [0001] The invention relates to a nutritional composition for promoting wound healing, bed sore repair and postoperative stress ulcer healing. Background technique [0002] With the acceleration of people's life rhythm, the increase of work pressure and the change of diet structure, in recent years, the problems of stress anxiety and trauma caused by disease and aging have become increasingly prominent, especially for perioperative patients, anxiety and Exogenous stimuli increase the occurrence of complications such as slow wound healing, decubitus ulcers and postoperative stress ulcers in this group of people. Many patients who are hospitalized for surgery will focus on the surgeon and the operation process, often ignoring pre-operative and post-operative psychological counseling and nutritional intervention, which prolongs the hospital stay, increases medical expenses, and even greatly increases the death rate. probability. At present, drugs are commonly ...

Claims

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Application Information

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IPC IPC(8): A61K38/39A23L33/105A23L33/18A61P17/02A61K38/01A61K38/17
CPCA61K38/011A61K38/1709A61K38/39A23L33/105A23L33/18A23V2002/00A61K2300/00A23V2250/55A23V2200/318Y02A50/30
Inventor 熊晓云任武贤
Owner YABAO PHARMA GRP CO LTD
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