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Composite material used for three-dimensional printing of porous tissue scaffold and preparation method thereof

A 3D printing, porous tissue technology, applied in the preparation of 3D printing porous tissue engineering scaffold composite materials, in the field of 3D printing porous tissue engineering scaffold composite materials, can solve the problem of inconvenient industrialization promotion and application, poor controllability of porosity and structure, The preparation process is cumbersome and other problems, and the effect of good osteogenesis, controllable microporous structure and good biocompatibility can be achieved.

Pending Publication Date: 2018-07-31
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the organic solvents that must be used in traditional preparation methods, the prepared tissue engineering scaffold materials have inevitable defects
At the same time, the preparation process is cumbersome, the controllability of porosity and structure is poor, and the molding is difficult, which is not convenient for industrialization and clinical application.

Method used

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  • Composite material used for three-dimensional printing of porous tissue scaffold and preparation method thereof
  • Composite material used for three-dimensional printing of porous tissue scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1: A kind of preparation method of 3D printing porous tissue engineering scaffold composite material of the present invention has the following steps:

[0059] 1) 50 parts of polycaprolactone and 10 parts of bioglass are placed in a container;

[0060] 2) the container is placed in a drying oven to dry and remove moisture;

[0061] 3) blending the dried raw materials in the above step 2) uniformly, the blending includes but not limited to two-step blending method or multi-step blending method;

[0062] 4) immediately obtain standby composite material after blending;

[0063] 5) Prepare the above step 4) standby composite material into silk or powder or granule or block;

[0064] 6) Place the composite material filament or powder or particle or block in step 5) in the material supply device of the 3D printer, and add 10 to the material supply device of the 3D printer at the same time 5 3D printing porous tissue engineering scaffolds can be prepared by heati...

Embodiment 2

[0065] Embodiment 2: A kind of preparation method of 3D printing porous tissue engineering scaffold composite material of the present invention has the following steps:

[0066] 1) 90 parts of polycaprolactone and 50 parts of bioglass are placed in a container;

[0067] 2) the container is placed in a drying oven to dry and remove moisture;

[0068] 3) blending the dried raw materials in the above step 2) uniformly, the blending includes but not limited to two-step blending method or multi-step blending method;

[0069] 4) immediately obtain standby composite material after blending;

[0070] 5) Prepare the above step 4) standby composite material into silk or powder or granule or block;

[0071] 6) Place the composite material filament or powder or particle or block in step 5) in the material supply device of the 3D printer, and add 10 to the material supply device of the 3D printer at the same time 6 3D printing porous tissue engineering scaffolds can be prepared by heati...

Embodiment 3

[0072] Embodiment 3: A kind of preparation method of 3D printing porous tissue engineering scaffold composite material of the present invention has the following steps:

[0073] 1) 70 parts of polycaprolactone and 30 parts of bioglass are placed in a container;

[0074] 2) the container is placed in a drying oven to dry and remove moisture;

[0075] 3) blending the dried raw materials in the above step 2) uniformly, the blending includes but not limited to two-step blending method or multi-step blending method;

[0076] 4) immediately obtain standby composite material after blending;

[0077] 5) Prepare the above step 4) standby composite material into silk or powder or granule or block;

[0078] 6) Place the composite material filament or powder or particle or block in step 5) in the material supply device of the 3D printer, and add 10 to the material supply device of the 3D printer at the same time 6 3D printing porous tissue engineering scaffolds can be prepared by heati...

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Abstract

The invention relates to a composite material used for three-dimensional printing of porous tissue scaffold and a preparation method thereof, the material is prepared from, by weight, 50-90 parts of polycaprolactone / polyactic acid / chitosan, 10-50 parts of bioglass / hydroxyapatite / beta-tricalcium phosphate, a composite is mixedly formed, 105-106 cells are added, active factors with suitable concentration are added, and blending printing is carried out during the three-dimensional printing. According to the method, the three-dimensional shape, poriness, a cellular structure can be controlled, biodegradation can be achieved, the mechanical property is effect is better, the mechanical property is better, and the biocompatibility is better.

Description

technical field [0001] The invention relates to a three-dimensional porous scaffold for the growth, reproduction and function recovery of tissue cells, in particular to a 3D printed porous tissue engineering scaffold composite material, and the invention also relates to a preparation method of the 3D printed porous tissue engineering scaffold composite material. Background technique [0002] The preparation of degradable materials with three-dimensional porous scaffold structures that are beneficial to the growth, reproduction and functional recovery of human or animal tissue cells is a new research field in tissue engineering in recent years. At present, the methods used to prepare porous scaffold materials at home and abroad mainly include fiber bonding method, solvent coating / particle leaching method, phase separation / emulsification method, and freeze-drying method. These methods can construct porous scaffold materials with relatively large pores, interconnected pores, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/18A61L27/10A61L27/12A61L27/38A61L27/22A61L27/50A61L27/54A61L27/56A61L27/58B33Y10/00B33Y70/00
CPCA61L27/10A61L27/12A61L27/18A61L27/20A61L27/227A61L27/3804A61L27/3808A61L27/3834A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/252A61L2300/414B33Y10/00B33Y70/00C08L5/08C08L67/04C08L89/00
Inventor 孙玉春陈科龙周永胜刘云松王勇田耘李榕
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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