5-aminolevulinic acid gel composition and application thereof

Abstract

The invention provides a 5-aminolevulinic acid gel composition, which is prepared from the following raw materials and auxiliary materials in parts by weight: 1 part of 5-aminolevulinic acid, 6 to 7 parts of substrates, 0.2 to 0.5 part of crosslinking agents, 30 to 50 parts of humectants, 2.5 parts of transdermal agents, 0.1 to 0.25 part of pH regulators and 50 parts of water. The invention also provides a gel paste preparation and a use thereof. The gel composition has good release and transdermal performance, good biocompatibility and no stimulation on mucosa positions, and achieves good effects on diagnosis and treatment of oral mucosa carcinogenesis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a 5-aminolevulinic acid gel composition and its application. Background technique [0002] Photodynamic research has promoted the development of biology and medicine, and then derived new technologies for tumor diagnosis and treatment - photodynamic diagnosis (Photodynamic diagnosis, PDD) and photodynamic therapy (Photodynamic therapy, PDT). Corresponding light source, the technology of diagnosing or treating tumor through photodynamic reaction. At present, PDT has become a new tumor therapy after traditional tumor therapies such as surgery, radiotherapy, chemotherapy and immunotherapy. [0003] Photodynamic diagnosis and treatment has the advantages of less trauma, less toxic and side effects, good selectivity, good repeatability, and can protect appearance and important organ functions, etc., and has gradually become a promising new method for tumors. PDT is also...

AI Technical Summary

Problems solved by technology

However, most of the 5-aminolevulinic acid products currently developed are emulsions or solutions, which are mainly used for oral and intravenous injection. However, when it is used on certain mucous membranes of the body, mucus will be secreted due to the stimulation of the mucous membranes, diluting or even diluting. Applying drugs, making the diagnosis and treatment of mucous membranes such as oral cavity, nasal cavity and urethral mucous membrane less effective

[0006] The patent with the publication number CN102670577A reports a photosensitizer composition comprising 5-aminolevulinic acid or its derivatives. The penetration enhancer used in it includes dimethyl sulfoxide, which is biologically toxic and not suitable for human use, and The oral mucosa is always in a moist state, and this patent does not consider the viscosity of the gel under this special condition

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