Biological polysaccharide bleeding stopping solution and preparation method thereof

A technology of sugar hemostasis and biopolysaccharide, which is applied in the field of biopolysaccharide hemostasis and its preparation, can solve the problems of poor biocompatibility, large tissue irritation, and inconvenient use, and achieve good biocompatibility, prevent bleeding, and maintain The effect of intraoperative visual field

Pending Publication Date: 2018-08-10
张博
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the common hemostatic products on the market are hemostatic gauze, hemostatic powder, etc. In practice, these products are inconvenient to use, have poor biocompatibility,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Biological Polysaccharide Derivative--Preparation of Cellulose Carboxymethyl Ether

[0024] Prepare a hydrogen peroxide solution with a concentration of 2%, add medical absorbent cotton fibers, soak evenly in circulation, shake dry, add sodium hydroxide solution, heat up to 30-85°C, stir well, perform dynamic chemical combination under ultrasonic conditions for 0.5-12h, then take it out , add a chloroacetic acid solution, continue the dynamic chemical combination for 1-30 hours, take it out, adjust the pH, and dry; add disodium hydrogen phosphate, sodium hydrogen phosphate, notoginseng saponin, and sorrel Alcohol fatty acid ester-80, carbomer, raise the temperature to 10-70°C, stir well, add the above-mentioned treated medical absorbent cotton fiber, carry out dynamic chemical combination under the condition of stirring or ultrasonic vibration for 2-12h to dry, Dry and serve.

Embodiment 2

[0026] Biological Polysaccharide Derivative--Preparation of Cellulose Carboxymethyl Ether

[0027] Prepare a hydrogen peroxide solution with a concentration of 3%, add medical absorbent cotton fibers, soak evenly in circulation, shake dry, add sodium hydroxide solution, heat up to 20-65°C, stir well, perform dynamic chemical combination under ultrasonic conditions for 0.5-10h, then take it out , add a chloroacetic acid solution, continue the dynamic chemical combination for 3 to 30 hours, take it out, adjust the pH, and dry it. In 50-95% ethanol solution, add ginsenoside, sodium carboxymethylcellulose, polysorbate-80, phosphate buffer, raise the temperature to 20-60°C, stir well, add the above-mentioned treated medical absorbent cotton The fiber is obtained by dynamic chemical combination under the condition of stirring or ultrasonic vibration for 2-12 hours, drying and drying.

Embodiment 3

[0029] Weigh 1 g of cellulose carboxymethyl ether with a viscosity of about 600 and a degree of substitution of 0.8 to 0.9, add it to 50 ml of normal saline, heat and stir under airtight conditions until it is completely dissolved, add 100 mg of tobramycin, degas it by ultrasonic or vacuum, press Filter, fill in a spray bottle under 100-grade aseptic conditions, and sterilize with cobalt 60 radiation to obtain the product. According to "GB / T 16886.9-2001 Biological Evaluation of Medical Devices", Part 9: Qualitative and Quantitative Framework of Potential Degradation Products requires animal experiments, and animal experiments show that it is completely absorbed in vivo within 6 weeks.

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PUM

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Abstract

The invention provides a biological polysaccharide bleeding stopping solution. The biological polysaccharide bleeding stopping solution is prepared from the following components: at least one of a biological polysaccharide derivative, folium callicarpae pedunculalae polysaccharide and sodium alginate, and sodium chloride. Compared with the prior art, the biological polysaccharide bleeding stoppingsolution has the advantages that 1) a product prepared by the invention is a transparent or semi-transparent viscous solution and is conveniently sprayed to wounds or ulcers; 2) intraoperative bleeding can be effectively reduced and an intraoperative view field is kept; 3) the product has a very good stopping effect on postoperative tissue adhesion; 4) the biological polysaccharide derivative, the folium callicarpae pedunculalae polysaccharide and the sodium alginate can be combined to use and have a cooperative effect; the product is used for carrying out body surface and intraoperative bleeding and also can be used for effectively preventing bleeding of gastrointestinal tracts; 5) the product can be degraded and absorbed by organisms and has good biocompatibility, and dangerous factorsin the operation are reduced; 6) when the product contains fungicide and can be used for effectively preventing intraoperative and postoperative bacterium and virus infection. The product prepared bythe invention can be used for cleaning exudation and oozing blood, clearing the operation view field, improving the operation quality and reducing postoperative complications.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a biological polysaccharide for hemostasis and a preparation method thereof. Background technique [0002] Trauma or perioperative bleeding and oozing often induce systemic or local, immediate or delayed complications, leading to adverse consequences and even life-threatening. According to statistics, the rate of abnormal bleeding in surgical operations is 0.5% to 40%, and that in cardiac operations can reach 12%. Research and development of hemostatic products for local application, rapid hemostasis and wound protection, which can effectively reduce the mistakes in the operation process caused by bleeding, and can also immediately stop bleeding and accelerate wound healing for bleeding caused by various traumas and burns function and save lives at critical moments. [0003] Most of the common hemostatic products on the market are hemostatic gauze, hemostatic powder, ...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/02A61L24/04A61L24/00A61L31/04A61L31/02A61L31/06A61L31/16A61L31/14
CPCA61L24/0015A61L24/0042A61L24/02A61L24/046A61L24/08A61L31/02A61L31/042A61L31/06A61L31/148A61L31/16A61L2300/406A61L2300/412A61L2400/04C08L5/04C08L71/02C08L1/286C08L1/28C08L5/00
Inventor 张博
Owner 张博
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