Biological polysaccharide bleeding stopping solution and preparation method thereof
A technology of sugar hemostasis and biopolysaccharide, which is applied in the field of biopolysaccharide hemostasis and its preparation, can solve the problems of poor biocompatibility, large tissue irritation, and inconvenient use, and achieve good biocompatibility, prevent bleeding, and maintain The effect of intraoperative visual field
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Embodiment 1
[0023] Biological Polysaccharide Derivative--Preparation of Cellulose Carboxymethyl Ether
[0024] Prepare a hydrogen peroxide solution with a concentration of 2%, add medical absorbent cotton fibers, soak evenly in circulation, shake dry, add sodium hydroxide solution, heat up to 30-85°C, stir well, perform dynamic chemical combination under ultrasonic conditions for 0.5-12h, then take it out , add a chloroacetic acid solution, continue the dynamic chemical combination for 1-30 hours, take it out, adjust the pH, and dry; add disodium hydrogen phosphate, sodium hydrogen phosphate, notoginseng saponin, and sorrel Alcohol fatty acid ester-80, carbomer, raise the temperature to 10-70°C, stir well, add the above-mentioned treated medical absorbent cotton fiber, carry out dynamic chemical combination under the condition of stirring or ultrasonic vibration for 2-12h to dry, Dry and serve.
Embodiment 2
[0026] Biological Polysaccharide Derivative--Preparation of Cellulose Carboxymethyl Ether
[0027] Prepare a hydrogen peroxide solution with a concentration of 3%, add medical absorbent cotton fibers, soak evenly in circulation, shake dry, add sodium hydroxide solution, heat up to 20-65°C, stir well, perform dynamic chemical combination under ultrasonic conditions for 0.5-10h, then take it out , add a chloroacetic acid solution, continue the dynamic chemical combination for 3 to 30 hours, take it out, adjust the pH, and dry it. In 50-95% ethanol solution, add ginsenoside, sodium carboxymethylcellulose, polysorbate-80, phosphate buffer, raise the temperature to 20-60°C, stir well, add the above-mentioned treated medical absorbent cotton The fiber is obtained by dynamic chemical combination under the condition of stirring or ultrasonic vibration for 2-12 hours, drying and drying.
Embodiment 3
[0029] Weigh 1 g of cellulose carboxymethyl ether with a viscosity of about 600 and a degree of substitution of 0.8 to 0.9, add it to 50 ml of normal saline, heat and stir under airtight conditions until it is completely dissolved, add 100 mg of tobramycin, degas it by ultrasonic or vacuum, press Filter, fill in a spray bottle under 100-grade aseptic conditions, and sterilize with cobalt 60 radiation to obtain the product. According to "GB / T 16886.9-2001 Biological Evaluation of Medical Devices", Part 9: Qualitative and Quantitative Framework of Potential Degradation Products requires animal experiments, and animal experiments show that it is completely absorbed in vivo within 6 weeks.
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