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Borosilicate bioglass/polyvinyl alcohol hybrid hydrogel preparation method and application

A technology of biological glass and borosilicate, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as rapid expansion, new bone deformity such as bone pack, low mechanical strength, etc., and achieve excellent biological activity and Effects of biocompatibility, promotion of angiogenesis, and excellent mechanical properties

Inactive Publication Date: 2018-08-17
TONGJI UNIV
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Problems solved by technology

However, at present, less than 10% of bone tissue repair materials and instruments are provided in the Chinese market, and the product variety is single, which cannot meet the needs of clinical and rapid expansion.
However, the current bioglass-related products are brittle, which limits their application. For example, the Chinese patent "a degradable porous bioactive glass support and its preparation method" (2004, CN1562834A), although the patented product has high bioactivity , but the mechanical strength is low, it is difficult to be used for the repair of load-bearing bone
Of course, this problem can be improved by compounding with organic materials. Some researchers disperse bioglass particles or fibers in polymers to improve the brittleness of bioglass when used alone, and at the same time improve the quality of polymers. Biological activity, but these patents use a simple two-phase compound, which has problems such as poor dispersion and low bonding strength of the two-phase interface
European patent "Composite material for bone repair based on acellular biological tissue matrix material and its preparation method" (2016, WO2017097104), uses microfibrillated animal tissue acellular matrix material as the organic component, and calcium salt bioceramics or glass as the Inorganic components form a bone repair composite material. Although the material has high bioactivity of bioglass or ceramics and degradable absorbability of acellular matrix, the composite process is too simple, resulting in poor uniformity of the composite material, which may lead to formation new bone deformity
Another example is the Chinese patent "a composite material of bioglass / amino acid polymer and its application" (2015, CN105536054A). This patent composites bioglass with amino acid polymer, and the resulting composite material has the high biological activity of bioglass and amino acid polymerization. Degradable and absorbable materials, but there is also the problem that the composite process is too simple, resulting in poor uniformity of the composite material, and may cause new bone deformities during use

Method used

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  • Borosilicate bioglass/polyvinyl alcohol hybrid hydrogel preparation method and application
  • Borosilicate bioglass/polyvinyl alcohol hybrid hydrogel preparation method and application
  • Borosilicate bioglass/polyvinyl alcohol hybrid hydrogel preparation method and application

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Effect test

Embodiment 1

[0037] Preparation method and performance characterization of borosilicate bioglass / polyvinyl alcohol hybrid hydrogel of the present invention

[0038] 1. Preparation method:

[0039] 1) Preparation of borosilicate bioglass sol by sol-gel method:

[0040] According to the composition of borosilicate bioglass in Table 1, bioglass sol was prepared. First, 80ml of absolute ethanol was used as solvent, and 26.7ml of tetraethyl orthosilicate, 0.1ml of concentrated nitric acid, and 4.3ml of deionized water were sequentially added to anhydrous In ethanol solvent, magnetically stirred and mixed for 30 minutes; then 7.1 g of boric acid was added, and magnetically stirred for 30 minutes; finally, 28.1 g of calcium nitrate tetrahydrate was added, and magnetically stirred for 3 hours to obtain borosilicate bioglass sol.

[0041] The purity of the raw materials used above was analytically pure, and the whole process was carried out in a constant temperature water bath at 40°C.

[0042] T...

Embodiment 2

[0056] Borosilicate bioglass / polyvinyl alcohol hybrid hydrogel for skin wound repair and its biological experiment

[0057] In order to measure the effectiveness of the bioglass / polyvinyl alcohol hybrid hydrogel in treating skin wounds, the bioglass / polyvinyl alcohol hybrid hydrogel prepared as described in Example 1 was cut into the size of the wound and used as a facilitator. Animal experiments on wound repair in rats.

[0058] Select 12 healthy mice that meet the experimental criteria for animal experiments. After the mice were fully anesthetized, the hair removal mechanical injury was performed on the back. The initial wound size was 3.5cm*3cm, and the depth reached 4mm. According to the wound size, the bioglass / polyvinyl alcohol hybrid hydrogel that was further disinfected was applied on the mouse wounds. After using the bioglass / polyvinyl alcohol hybrid hydrogel, the wound stopped bleeding rapidly at the initial stage, the wound area narrowed faster, and the healing cy...

Embodiment 3

[0060] Borosilicate bioglass / polyvinyl alcohol hybrid hydrogel for bone defect repair and its biological experiments

[0061] In order to measure the effectiveness of the bioglass / polyvinyl alcohol hybrid hydrogel in treating bone defects, the bioglass / polyvinyl alcohol hybrid hydrogel prepared as described in Example 1 was cut into the size of the bone defect and used as Animal experiments to promote the repair of rat skull defects.

[0062] The material was verified by a rat skull defect model, and the main steps were as follows: firstly, intraperitoneal injection of 1% sodium pentobarbital at a dose of 40 mL / kg was used for intraperitoneal anesthesia, and 200 μL of penicillin was injected intramuscularly. After general anesthesia, the limbs were immobilized. Hair was shaved and the head was disinfected with 75% alcohol. A longitudinal incision was made in the middle of the skull, and the skin and periosteum were incised to fully expose the skull. Under the premise of ensu...

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Abstract

The invention belongs to the technical field of biomaterials for bone defect repairing and skin wound repairing and relates to a borosilicate bioglass / polyvinyl alcohol hybrid hydrogel preparation method and application. The method includes: preparing borosilicate bioglass sol according to a sol-gel method, dissolving polyvinyl alcohol into water to prepare polyvinyl alcohol aqueous solution, mixing bioglass sol with polyvinyl alcohol aqueous solution according to a mass ratio of 0.1-1:1, performing stirring, polymerization reaction, aging, freezing, unfreezing and the like to form hydrogel, and adopting alkaline liquor for neutralization treatment to obtain borosilicate bioglass / polyvinyl alcohol hybrid hydrogel. A product prepared according to the method is high in biocompatibility, biological activity, bone inductivity, tissue regenerability and the like and effective as a series of biomaterials for skin wound repairing and bone tissue regeneration and repairing.

Description

technical field [0001] The invention relates to a preparation method and application of borosilicate bioglass / polyvinyl alcohol hybrid hydrogel. The invention belongs to the technical field of biomaterials used for bone defect repair and skin wound repair. Background technique [0002] Bone tissue is the largest tissue and organ in the human body, and its defect or dysfunction is one of the main hazards to human health, and it is also one of the main causes of human disease and death. The incidence of bone injury is relatively high due to various reasons such as trauma (traffic, natural disaster, sports, work injury), disease (inflammation, tumor) and congenital factors. Coupled with environmental pollution, side effects of drugs, alcoholism, the growth of aging trends, and the development of modern transportation, the number of patients with bone tissue injuries has shown an obvious upward trend. The huge number of patients with hard tissue defects directly leads to a hug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/52A61L27/50A61L27/44
CPCA61L27/446A61L27/50A61L27/52A61L27/58A61L2430/02C08L29/04
Inventor 王德平庞力斌汤悦谢昕常宇辰
Owner TONGJI UNIV
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