Double-layered core-shell structure molecular carrier

A core-shell structure and molecular technology, applied in the field of medical materials and biomaterials, can solve problems such as lack of contrast performance, and achieve the effect of improving sensitivity

Active Publication Date: 2018-08-24
WUXI PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common photothermal conversion molecular probes, such as gold nanorods and copper sulfide nanoparti

Method used

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  • Double-layered core-shell structure molecular carrier
  • Double-layered core-shell structure molecular carrier
  • Double-layered core-shell structure molecular carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1: Preparation of core-shell structure targeting molecular probes

[0054] 1. Preparation of Na x wxya 3 Nano stave

[0055] Using an improved high-temperature pyrolysis method, the preparation of Na x wxya 3 Nanorods, the preparation process is as follows: add 10mL oleic acid, 30mL octadecene 0.2mmol and GdCl 3 · 6H2O (74.34mg) powder, pass through argon for 5min, slowly raise the temperature to 160°C and stir for 1h. A light yellow clear liquid was obtained, and then the heating was stopped to allow the system to cool down to room temperature naturally. Slowly add 5mL ammonia solution (containing 659.72mg Na 2 WO 4 2H 2 (0), sealed and stirred at room temperature for 3 h, the solution was yellow-white, followed by argon for 5 min to remove the air in the system, kept at 50 ° C for 1 h, kept at 80 ° C for 1 h, and kept at 120 ° C for 1 h to remove ammonia.

[0056] After the removal, the condenser tube was connected, and the system began to heat up. Th...

Embodiment 2

[0063] Example 2: Preparation of core-shell structure targeting molecular probes by microwave modification

[0064] According to the preparation method of Example 1, in the second step of hydrophilic modification, Na x wxya 3 After the cyclohexane in the upper layer was transferred to deionized water, it was collected by centrifugation, and the whole process was washed with deionized water and ultrasonically dispersed, and repeated three times. followed by drying to obtain Na x wxya 3 nanorod powder. Then in a microwave generator, treat at a frequency of 2450MHz for 8s, and then disperse in 10mL deionized water. During microwave treatment, Na x wxya 3 The thickness of the nanorod powder is not more than 1 cm. Subsequent operations are the same as in Example 1.

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Abstract

The invention provides a double-layered core-shell structure molecular carrier. The double-layered core-shell structure molecular carrier is characterized in that a modified sodium gadolinium tungstate nano-rod NaxGdWO3 is used as an inner core and the outer surface of the inner core is coated with mesoporous silicon dioxide; a double-layered structure is WCMSNs. The molecular carrier not only canbe used for carrying out magnetic resonance imaging and photo-thermally burning tumor cells to die, but also can load various medicines or target molecules, so that drug treatment or targeting localization is carried out on the basis of the magnetic resonance imaging and photo-thermal treatment.

Description

technical field [0001] The invention relates to the technical field of medical materials and biological materials, in particular to a molecular carrier with a double-layer core-shell structure. Background technique [0002] The core-shell is a nanoscale ordered assembly structure formed by one nanomaterial wrapping another nanomaterial through chemical bonds or other forces. Due to its unique structural characteristics, the core-shell structure integrates the properties of the two materials inside and outside, and complements each other's shortcomings. It is an important research direction in recent years that the shape determines the properties. And separation has broad application prospects. [0003] Core-shell nanoparticles have been applied in many fields of biomedicine, and have many potential application values. In the field of biomedicine, core-shell nanoparticles are mainly used in drug delivery control, biological imaging, cell labeling, biosensors, and regenerati...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/02A61K47/04A61K47/42A61K41/00A61K49/08A61K49/16A61K49/18A61P35/00A61P35/04C01G41/00
CPCA61K9/5115A61K9/5169A61K41/0052A61K49/08A61K49/16A61K49/1884A61P35/00A61P35/04C01G41/006C01P2004/16
Inventor 方向明步文博陈宏伟倪大龙吴婉璐邹健姚振威胡晓云胡春洪
Owner WUXI PEOPLES HOSPITAL
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