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A kind of Chuanwang anti-inflammatory tablet and its preparation process

The technology of anti-inflammatory tablet and Gewang is applied in the field of Chuanwang anti-inflammatory tablet and its preparation, which can solve the problems affecting drug quality and curative effect, and achieve the effects of reducing weight difference, high safety and reducing adverse effects.

Active Publication Date: 2021-04-23
GUANGDONG YILI LUODING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets have the advantages of accurate dosage, small volume, and are convenient for taking, storing and transporting. At the same time, they can also be made into different types according to different needs. However, there are large weight differences between tablets made by existing processes. Differences greatly affect the quality and curative effect of drugs, and this is also a technical problem that has always existed in this field

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of embodiment 1 modified wheat bran base material

[0040]S1. Grinding wheat bran to 2000 mesh, then mixing with microcrystalline cellulose and water, raising the temperature to 45° C., and stirring for 25 minutes to obtain a mixed solution; wherein, the ratio of solid to liquid of wheat bran, microcrystalline cellulose and water is 1: 0.4g:11;

[0041] S2, add initiator K to the mixed solution 2 S 2 o 8 , heated in a water bath, stirred for 60min, then added dropwise pure acrylic acid, stirred for 2.5h, to obtain a reaction solution, wherein the volumetric dosage of acrylic acid was 1 / 2 of the volume of the mixed solution; 2 S 2 o 8 The weight ratio to wheat bran is 0.012:1;

[0042] S3. Cool the reaction solution to 75°C, add polyethylene glycol-4000, stir for 60 minutes, then cool to room temperature, filter with suction, wash with absolute ethanol until no raw materials remain, and dry to obtain; among them, polyethylene glycol- The volume ra...

Embodiment 2

[0043] The preparation of embodiment 2 organic nanometer talcum powder

[0044] Prepare polyvinyl alcohol into a solution with a mass fraction of 0.5%, add talc powder after 1 hour, stir at 85°C for 6 hours, centrifuge to remove the supernatant, and freeze-dry to obtain the product. Among them, the mixture of polyvinyl alcohol and talc powder The weight ratio is 0.3:1.

Embodiment 3

[0045] The preparation of embodiment 3 Chinese medicine extracts

[0046] Grind Andrographis paniculata and Liaogewang to 50-100 mesh, add 5 times the volume of distilled water, put the solution in a fermenter, and add 3‰ cellulase and 3‰ pectinase, pH6.0, ferment at 35°C for 2 hour, aerobic stirring and filtering to obtain the filtrate; adding activated carbon to the above-mentioned filtrate for decolorization and filtering, and the amount of activated carbon added is 1.5% of the total amount of the filtrate; the above-mentioned obtained filtrate is passed through a D152 resin column, and the flow liquid is collected and pasteurized. The resulting liquid is concentrated to a clear paste with a relative density of 1.20 to obtain a traditional Chinese medicine extract.

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a Chuanwang Xiaoyan Tablet and its preparation process. The invention mainly consists of the following ingredients and their parts by weight: 6-8 parts of modified wheat bran base material, 4-4 parts of functional nano-carrier 6 parts, 25-60 parts of Chinese medicine extract, 5-7 parts of dextrin, 6-8 parts of sodium carboxymethyl starch, 1.4-1.6 parts of magnesium stearate; Uniform and slow release, high bioavailability, long drug effect time, high safety factor, low nephrotoxicity, high stability, and small weight difference.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a Chuanwang anti-inflammatory tablet and a preparation process thereof. Background technique [0002] Chuanwang Xiaoyan Tablets, anti-inflammatory and detoxification, used for phlegm-heat cough, abdominal pain, acute and chronic tonsillitis, pharyngitis, pneumonia, acute gastroenteritis, acute bacillary dysentery with the above symptoms. Chuanwang Xiaoyan Tablets are prepared from Andrographis paniculata and Liaogewang two traditional Chinese medicines, of which Andrographis paniculata is the main drug in the prescription, and the diterpene lactone component dehydroandrographolide contained in it is effective in clearing away heat and detoxification, reducing inflammation and pain, and antibacterial and antiviral. Components, due to the low water solubility of andrographolide, solid preparations are often used, but the absorption of d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K36/83A61K47/46A61P11/14A61P11/06A61P29/00A61P1/00A61P11/04A61P11/00A61P1/12A61P31/04
CPCA61K9/2068A61K36/19A61K36/83A61K2236/19A61K2236/331A61K2236/55A61K2300/00
Inventor 曾胜
Owner GUANGDONG YILI LUODING PHARMA