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Preparation process of traditional Chinese medicine granules and prepared traditional Chinese medicine granules

A technology of traditional Chinese medicine granules and preparation process, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., which can solve the problems of increasing process production costs, low one-time molding rate of granules, and the use of excipients Difficult to accurately control the quantity and other issues

Active Publication Date: 2020-10-27
叶新苗
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of ethanol increases the production cost of the process, and it is often difficult to accurately control the amount of excipients, which leads to problems such as low molding rate of granules at one time and poor quality stability of granules.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0054] A preferred embodiment, decoction extraction process parameters include:

[0055] The extraction pressure is 0.06-0.12MPa, and / or, the extraction temperature is 100-110°C, and / or, the extraction time is 30-60min;

[0056] Typical but non-limiting examples of extraction pressure are 0.06MPa, 0.07MPa, 0.08MPa, 0.09MPa, 0.1MPa, 0.11MPa or 0.12MPa.

[0057] Typical but non-limiting examples of extraction temperature are 100°C, 101°C, 102°C, 103°C, 104°C, 105°C, 106°C, 107°C, 108°C, 109°C or 110°C.

[0058] Typical but non-limiting examples of extraction time are 30 min, 35 min, 40 min, 45 min, 50 min, 55 min or 60 min.

[0059] The mesh number of the filter bag used for solid-liquid separation is 60-120 mesh.

[0060] Typical but non-limiting meshes of filter bags used for solid-liquid separation are, for example, 60 mesh, 70 mesh, 80 mesh, 90 mesh, 100 mesh, 110 mesh or 120 mesh.

[0061] High-speed separation and purification refers to the process of achieving separati...

Embodiment 1

[0116] A preparation process of traditional Chinese medicine granules, comprising the following steps:

[0117] (a) Soak the raw material medicine of formula quantity with 20 ℃ water for 30min;

[0118] The raw material medicine comprises the following components by weight: 8 parts of hawthorn, 8 parts of tangerine peel, 15 parts of Sophora japonica, 15 parts of kudzu root, 15 parts of Chinese yam, 18 parts of Polygonatum odoratum, 22 parts of oyster, 15 parts of mulberry leaf, and 20 parts of mulberry and papaya 10 parts;

[0119] (b) decocting and extracting the soaked raw material medicine, the decoction extraction process parameters include: extraction pressure is 0.06MPa, extraction temperature is 100°C, and extraction time is 30min;

[0120] Solid-liquid separation is carried out after the decoction is extracted, and the filter bag used for solid-liquid separation has a mesh size of 60 mesh to obtain an extract;

[0121] (c) Perform high-speed separation and purificati...

Embodiment 2

[0126] A preparation process of traditional Chinese medicine granules, comprising the following steps:

[0127] (a) Soak the raw material medicine of formula quantity with 30 ℃ water for 80min;

[0128] The raw material medicine comprises the following components by weight: 8 parts of hawthorn, 8 parts of tangerine peel, 15 parts of Sophora japonica, 15 parts of kudzu root, 15 parts of Chinese yam, 18 parts of Polygonatum odoratum, 22 parts of oyster, 15 parts of mulberry leaf, and 20 parts of mulberry and papaya 10 parts;

[0129] (b) Decocting and extracting the soaked crude drug, the decoction extraction process parameters include: extraction pressure of 0.12MPa, extraction temperature of 110°C, and extraction time of 60 minutes;

[0130] Carry out solid-liquid separation after the decoction is extracted, and the mesh number of the filter bag used for solid-liquid separation is 120 mesh to obtain the extract;

[0131] (c) Perform high-speed separation and purification on ...

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PUM

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Abstract

The invention provides a traditional Chinese medicine granule preparation process and traditional Chinese medicine granules prepared through the same, and relates to the technical field of traditionalChinese medicine granules. The granule preparation process comprises the following steps that bulk drugs are subjected to decocting and extracting, and leaching liquor is obtained after solid-liquidseparation is carried out; the leaching liquor is subjected to high-speed centrifugation, separation and purification, and concentrated liquor is obtained; accessories are added into the concentratedliquor, after the materials are mixed to be uniform, drying is carried out, and extract powder is obtained; the traditional Chinese medicine granules are obtained through dry granulation. According tothe traditional Chinese medicine granule preparation process, a high-speed centrifugation, separation and purification method and a dry granulation mode are combined for use, the effective ingredients of traditional Chinese medicine can be enriched to the maximum degree, the wastage rate of the effective ingredients is reduced, the use amount of the accessories is reduced, and the production costis reduced. The traditional Chinese medicine granule preparation process has the advantages of being high in raw material utilization rate, high in production efficiency, low in production cost, highin effective ingredient content and the like.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicine granules, in particular to a preparation process of traditional Chinese medicine granules and the prepared traditional Chinese medicine granules. Background technique [0002] The traditional method of clinical treatment of traditional Chinese medicine is traditional Chinese medicine decoction, but traditional Chinese medicine decoction has disadvantages such as bitter taste, tedious and time-consuming decoction process, and inconvenient transportation and storage. With the advancement of technology, traditional Chinese medicine granules have been gradually developed on the basis of traditional Chinese medicine decoctions, which can effectively solve various shortcomings of decoctions. At present, the general manufacturing process of traditional Chinese medicine granules is "material selection-removal of impurities-extraction-concentration-drying-granulation". G...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/8969A61K35/618
CPCA61K9/1652A61K9/1682A61K35/618A61K36/488A61K36/489A61K36/605A61K36/732A61K36/734A61K36/752A61K36/8945A61K36/8969A61K2300/00
Inventor 叶新苗叶肖琳
Owner 叶新苗