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Surface-enhanced Raman spectroscopy sensor based on electrochemical deposition and molecular imprinting and its preparation method

A surface-enhanced Raman and spectral sensor technology, applied in the direction of material electrochemical variables, scientific instruments, Raman scattering, etc., can solve the problems of poor combination of imprinted polymers and precious metals, decreased detection reproducibility and repeatability, and complicated preparation processes and other problems, to achieve the effect of promoting integration, fast detection speed, and simple preparation process

Active Publication Date: 2021-02-26
SHANGHAI INST OF TECH
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  • Claims
  • Application Information

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Problems solved by technology

However, most of the existing methods use the sol-gel method to prepare nano-noble metal microspheres, and then coat the molecularly imprinted polymer film on the microspheres to form a core-shell structure. Although good detection sensitivity can be obtained, the preparation process is complicated and difficult. There are problems with uncontrollable conditions or poor combination of imprinted polymers and precious metals, resulting in decreased detection reproducibility and repeatability

Method used

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  • Surface-enhanced Raman spectroscopy sensor based on electrochemical deposition and molecular imprinting and its preparation method
  • Surface-enhanced Raman spectroscopy sensor based on electrochemical deposition and molecular imprinting and its preparation method
  • Surface-enhanced Raman spectroscopy sensor based on electrochemical deposition and molecular imprinting and its preparation method

Examples

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Effect test

Embodiment 1

[0023] In this example, the preparation of theophylline molecularly imprinted-SERS sensor is carried out based on electrochemical technology, and the flow chart is shown in figure 1 , including the following steps:

[0024] (1) Glassy carbon electrode pretreatment: first place the GCE on the suede, polish it with 1.0μm, 0.3μm and 0.05μm alumina powder in turn, and then ultrasonicate in deionized water for 3 minutes; then in potassium ferricyanide solution , carry out cyclic voltammetry scanning in the voltage range of -0.3 ~ 0.6V, until a reversible and stable redox peak appears; finally, use the current-time curve technique to test the GCE at 0.1mol L -1 The activation was carried out in PBS solution with pH 7.0, the activation potential was 2.0V, and the time was 200s.

[0025] (2) Preparation of p-o-Pd / ThPh / GCE: first prepare the electropolymerization solution, weigh the functional monomer o-phenylenediamine (o-Pd) and the template molecule theophylline (ThPh) and dissolve...

Embodiment 2

[0028] The difference between this embodiment and Example 1 is that the template molecule in step 2 is theophylline-7-acetic acid. Others are the same as in Embodiment 1.

Embodiment 3

[0030] The difference between this embodiment and Example 1 is that the template molecule in step 2 is guanine. Others are the same as in Embodiment 1.

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Abstract

The invention discloses a surface-enhanced Raman spectrum sensor based on electrochemical deposition and molecular imprinting and a preparation method thereof. In the present invention, based on the molecular imprinting technology, template molecules and functional monomer aniline are electrically polymerized on the surface of the glassy carbon electrode GCE to form molecularly imprinted polymer films MIPs; then, nano-silver particles AgNPs are synthesized on the surface of the MIPs by electrochemical deposition; finally the template Molecular elution is removed to obtain an electrode sensor based on nano-silver-molecularly imprinted polymer film modification. The preparation method of the invention is simple and fast; the obtained sensor can realize fast, sensitive and selective detection of target molecules. Combined with a portable Raman spectrometer, the invention can also meet the actual detection requirements of on-site, rapid and high-throughput.

Description

technical field [0001] The invention relates to the technical field of nanomaterial preparation and surface-enhanced Raman spectroscopy detection, and in particular, provides a surface-enhanced Raman spectroscopy sensor based on electrochemical deposition and molecular imprinting and a preparation method thereof. Background technique [0002] At present, the analysis and detection of target compounds in actual samples still faces certain challenges, because the actual sample matrix is ​​often very complex, there are many structural analogues of the target molecule, or the content in the sample is very low, so the analysis method is required to have better anti-interference capability and high sensitivity. Molecular imprinting (MIT) technology, using target molecules as templates, can specifically identify and separate target molecules in complex matrices to achieve effective separation and enrichment. It has been widely used in analysis and detection in the fields of environ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65G01N21/33G01N27/30G01N27/48
CPCG01N21/33G01N21/658G01N27/30G01N27/48
Inventor 李原婷葛璇杓蔺华林韩生薛原杨圆圆
Owner SHANGHAI INST OF TECH
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