Anti-epileptic pharmaceutical composition and preparation method thereof
An anti-epileptic drug and composition technology, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve the problems of short duration of curative effect, and achieve the effects of enhancing immunity, reasonable and accurate process design, and improving the oxygen supply function of cells
Inactive Publication Date: 2018-09-28
孟斯琴
View PDF13 Cites 1 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0006] The present invention aims at the defects of short duration of curative effect and various chronic side effects of common antiepileptic drug compositions at present, and selects broad-spectrum antiepileptic drug C Magnesium valerate is the main ingredient, and a lot of exploration and research have been carried out on the active ingredients, excipients and dosages used in combination with it, in order to obtain an antiepileptic drug composition that can reduce related side effects and improve curative effect
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1-6
[0035] Table 1. Embodiment 1-6 antiepileptic drug composition raw materials and dosage (parts by weight)
[0036]
[0037]
[0038] Among them, the preparation method of the above-mentioned Yizhiren extract is as follows: select plump Yizhiren, remove the shell, put it into 0.2-0.6wt% sodium chloride solution for 10-16 hours, take it out and drain it, and grind it fully in a grinder Finally, add 3-5 times the weight of 70% ethanol, and stir evenly; the slurry is boiled for 40-60min, and filtered through a 200-400 mesh filter cloth; It is obtained by high-temperature sterilization at 110-120°C, drying and ultrafine grinding.
[0039] The preparation method of above-mentioned antiepileptic drug composition, comprises the following steps:
[0040] 1) Mixing of main ingredients: Weigh magnesium valproate, L-carnosine, and Yizhiren extract, mix them evenly at 20-30°C, pass through a 200-300 mesh sieve, put them in a sealed bag and vacuumize them, 10 Freeze at -15°C for later ...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
| Property | Measurement | Unit |
|---|---|---|
| Sheet weight | aaaaa | aaaaa |
Login to View More
Abstract
The invention relates to the technical field of pharmaceutical compositions, in particular to an anti-epileptic pharmaceutical composition and a preparation method thereof. The anti-epileptic pharmaceutical composition comprises the following raw materials of, by weight, 20-65 parts of magnesium valproate, 10-30 parts of L-carnosine, 5-20 parts of alpiniae oxyphyllae fructus extracts, 3-8 parts ofpovidone K30, 2-6 parts of magnesium stearate, 3-10 parts of lauryl alcohol polyoxyethylene, 2-8 parts of antioxidants, 1-6 parts of surfactants, and 60-100 parts of lactose anhydrous. The preparation method includes the steps of mix treatment of main ingredients, mixing sterilization and pressing. The anti-epileptic pharmaceutical composition is simple in preparation process and suitable for industrial production, the side reaction of existing anti-epileptic pharmaceutical compositions can be reduced after medication, and the curative effect on epilepsy is improved.
Description
technical field [0001] The invention relates to the technical field of pharmaceutical compositions, in particular to an antiepileptic pharmaceutical composition and a preparation method thereof. Background technique [0002] Epilepsy is a neurological disease, which is a transient brain dysfunction caused by sudden abnormal discharge due to brain neuron lesions or damage. The pathogenesis of epilepsy is relatively complex, and the essence of its seizures is the excessive synchronous discharge of brain neurons. The abnormal discharge of neurons is closely related to neurotransmitters, ion channels, plasticity of synapses, glial cells and other factors. [0003] At present, the treatment of epilepsy includes drug therapy, surgical treatment, neuromodulation therapy, etc. The treatment of epilepsy at home and abroad is mainly based on drug therapy. Phenobarbital, phenytoin, carbamazepine, and magnesium valproate are currently widely used first-line antiepileptic drugs, but th...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More IPC IPC(8): A61K38/05A61K9/20A61K47/32A61P25/08A61K31/19A61K36/9062
CPCA61K9/2027A61K9/2095A61K31/19A61K36/9062A61K38/05A61K2300/00
Inventor 孟斯琴
Owner 孟斯琴