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A high-strength injectable intraocular lens material and its preparation method and application

An intraocular lens, high-strength technology, applied in the field of biomedicine, can solve the problems of unavoidable cataract surgery complications, poor physical and mechanical strength of human lens, etc., achieve controllable drug loading rate, reduce non-specific drug release behavior, reduce the damaging effects of

Active Publication Date: 2020-05-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem solved by the present invention is to provide a high-strength injectable intraocular lens material to solve the problem that the physical and mechanical strength of the injectable human lens in the prior art is not good, and the potential complications after cataract surgery cannot be avoided.

Method used

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  • A high-strength injectable intraocular lens material and its preparation method and application
  • A high-strength injectable intraocular lens material and its preparation method and application
  • A high-strength injectable intraocular lens material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This example provides the preparation of the intraocular lens material of the present invention.

[0035] 1 Preparation of prodrug monomer

[0036] Dissolve 130.10 mg of anhydrous hydroxyethyl methacrylate and 357.79 mg of indomethacin in 20 ml of anhydrous dichloromethane under stirring conditions to obtain a solution; add N,N'-dicyclohexylcarbodi 412.66 mg of imine and 244.32 mg of 4-dimethylaminopyridine were stirred and reacted at room temperature for 24 hours; the reaction was detected by TCL, and after the reaction was complete, the reaction solution was washed with water, dried and filtered, and rotary distilled; the resulting product was redissolved in a small amount of di Chloromethane, purified by silica gel chromatography, and then converted to indomethacin-HEMA prodrug monomer after rotary distillation. Obtain prodrug monomer 303.56mg, yield is 62.21% The NMR spectrum of indomethacin-HEMA is as attached figure 1 shown.

[0037] 2 select the monomer

[00...

Embodiment 2

[0046] This example provides the preparation of the intraocular lens of the present invention.

[0047] 1 Preparation of prodrug monomer

[0048] Prepared by the method of Example 1, the indomethacin-HEMA prodrug monomer was obtained.

[0049] 2 select the monomer

[0050] The monomers used in this embodiment and their consumption are shown in the table below:

[0051] type name Dosage (wt%) Thermosensitive functional monomer Vinylpyrrolidone 75 Acrylate monomer Methyl methacrylate 15 prodrug monomer Indomethacin-HEMA 7.5 crosslinking agent Butanediol dimethacrylate 0.5 Initiator Dibenzoyl peroxide 2

[0052] 3. Preparation of intraocular lens materials

[0053] The above four monomers and initiators were mixed uniformly under the protection of nitrogen and then poured into a glass mold, heated and polymerized in an oven at 60°C for 18 hours, then the temperature was raised to 90°C, and the reaction was continued for 6...

Embodiment 3

[0056] This example provides the preparation of the intraocular lens of the present invention.

[0057] 1 Preparation of prodrug monomer

[0058] Prepared by the method of Example 1, the indomethacin-HEMA prodrug monomer was obtained.

[0059] 2 select the monomer

[0060] The monomers used in this embodiment and their consumption are shown in the table below:

[0061] type name Dosage (wt%) Thermosensitive functional monomer Dimethylaminoethyl methacrylate 85 Acrylate monomer Methyl methacrylate 5 prodrug monomer Indomethacin-HEMA 7.5 crosslinking agent Hexylene glycol acrylate 0.8 Initiator ammonium peroxodisulfate 1.7

[0062] 3. Preparation of intraocular lens materials

[0063] Dissolve the above four monomers and initiators in 5ml of acetic acid: water = 1:1 under the protection of nitrogen, then inject into the glass mold, heat and polymerize in an oven at 60°C for 18 hours, then raise the temperature to 90°C,...

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Abstract

The invention discloses a high-strength injectable intraocular lens material and a preparing method and application thereof. The problems that in the prior art, an injectable intraocular lens is poorin physical mechanical strength, and potential complications appearing after a cataract surgery cannot be avoided are solved. The high-strength injectable intraocular lens material is formed by polymerization of four monomers, and the four monomers comprise the thermosensitive functional monomer, the acrylate monomer, the prodrug monomer and a cross-linking agent. The preparing method of the high-strength injectable intraocular lens material comprises the steps that the thermosensitive functional monomer, the acrylate monomer, the prodrug monomer and the cross-linking agent are mixed with an initiator, then reacting is conducted for 0.5-24 hours at the temperature of 50-100 DEG C, products are separated to remove unreacted micromolecule monomers, and thus the high-strength injectable intraocular lens material is obtained. The high-strength injectable intraocular lens material is scientific in composition and reasonable in proportion, and all the compositions play a role jointly, so that the prepared intraocular lens material has the good mechanical strength and optical properties and can effectively reduce complications of ophthalmic surgery.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a high-strength injectable intraocular lens material and its preparation method and application. Background technique [0002] Cataract is a common middle-aged and elderly eye disease. It mainly manifests as opacity of the lens itself or the lens capsule. Clinically, surgery can only be used to restore vision to the patient, that is, cataract extraction and intraocular lens implantation. Although cataract surgery has developed quite maturely, there are still some potential postoperative complications that may lead to vision loss or even blindness after surgery; such as postoperative endophthalmitis and post-cataract. [0003] According to their hardness, intraocular lenses can be divided into rigid intraocular lenses and foldable intraocular lenses. The main material of rigid intraocular lens is polymethacrylate (PMMA). Although it has the characteristics of good...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/54C08F283/06C08F220/34C08F226/10C08F220/54C08F220/14C08F222/14C08F222/20
CPCA61L27/18A61L27/54A61L2300/216A61L2300/406A61L2300/41A61L2300/43A61L2400/06A61L2430/16C08F220/34C08F220/54C08F226/10C08F283/06C08L51/08C08L33/24C08L39/06C08L33/14C08F220/14C08F222/102
Inventor 聂宇邹孟玮胡艳飞王海波王云兵
Owner SICHUAN UNIV
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