Semaglutide contained oral prolonged-release preparation and preparation method thereof
A sustained-release preparation, semaglutide technology, applied in medical preparations containing active ingredients, medical preparations with non-active ingredients, pill delivery, etc., can solve the problem of high cost for patients
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[0031] Example 1
[0032] Prescription of oral sustained-release preparations containing semaglutide (content per tablet)
[0033]
[0034] The original and auxiliary materials were passed through an 80-mesh sieve, and set aside, and the prescription amount of 1000 pieces of samples was configured.
[0035] ①Weigh semaglutide, metformin, cellulose acetate, ethyl cellulose, and polyethylene glycol according to the prescription amount; dissolve polyethylene glycol, semaglutide, and metformin in 1 mL of water as the internal water phase W1 ; Dissolve cellulose acetate in 10 mL of dichloromethane as the organic phase O; dissolve polyvinyl alcohol in 50 mL of water as the outer water phase W2;
[0036] ②Add the internal water phase W1 to the organic phase O, and phacoemulsify at a power of 250W for 10 minutes to form uniform colostrum W1 / O;
[0037] ③The colostrum W1 / O is added to the outer water phase W2, and the power is 250W phacoemulsified for 10 minutes to form a double emulsion W1 / O / W...
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[0042] Example 2
[0043] Prescription of oral sustained-release preparations containing semaglutide (content per tablet)
[0044]
[0045] The original and auxiliary materials were passed through an 80-mesh sieve, and set aside, and the prescription amount of 1000 pieces of samples was configured.
[0046] ①Weigh semaglutide, ciglitazone, cellulose acetate, polyethylene, and Tween-80 according to the prescription amount; dissolve Tween-80, semaglutide, and ciglitazone in 2 mL of water as Inner water phase W1; cellulose acetate and polyethylene are dissolved in 10 mL of dichloromethane as the organic phase O; polyvinyl alcohol is dissolved in 100 mL of water as the outer water phase W2;
[0047] ②Add the internal water phase W1 to the organic phase O, and phacoemulsify at 300W for 8min to form uniform colostrum W1 / O;
[0048] ③The colostrum W1 / O is added to the outer water phase W2, and the power is 300W phacoemulsified for 8 minutes to form a double emulsion W1 / O / W2;
[0049] ④The doub...
Example Embodiment
[0053] Example 3
[0054] Prescription of oral sustained-release preparations containing semaglutide (content per tablet)
[0055]
[0056] The original and auxiliary materials were passed through an 80-mesh sieve, and set aside, and the prescription amount of 1000 pieces of samples was configured.
[0057] ①Weigh semaglutide, pioglitazone, ethyl cellulose, polyethylene, and mannitol according to the prescription amount; dissolve mannitol, semaglutide, and pioglitazone in 2 mL of water as the internal water phase W1; ethyl cellulose , Polyethylene is dissolved in 10mL of dichloromethane, as the organic phase O; Polyvinyl alcohol is dissolved in 100mL of water, as the outer water phase W2;
[0058] ②Add the internal water phase W1 to the organic phase O, and phacoemulsify at a power of 350W for 7 minutes to form uniform colostrum W1 / O;
[0059] ③The colostrum W1 / O is added to the outer water phase W2, and the power is 350W for phacoemulsification for 7 minutes to form a double emulsion ...
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