Preparation method of anti-migration protein transportation carrier material

A carrier material and anti-migration technology, applied in the field of medical materials, can solve problems such as unfixation, postoperative instability, and difficult operation, and achieve good bioadhesion, prolong residence time, and improve the effect of action time

Inactive Publication Date: 2018-10-02
姜香
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide an anti-migration protein transport carrier material for the existing carrier material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0015] Example 1

[0016] Take pig tooth soap and vacuum freeze-dry, pulverize and pass through a 200-mesh sieve to obtain a sieved powder and add the sieved powder to a 55% ethanol solution by mass fraction, stir and mix, and place in a water bath at 65°C Heating for 2 hours, standing to cool to room temperature, filtering and collecting the filtrate, and rotating the filtrate to 1 / 5 of the original volume at 55°C to obtain the rotary evaporation liquid and adding it to a macroporous adsorption resin column, and then using a mass fraction of 30 % ethanol solution elution treatment, control the elution rate of ethanol solution to 2BV / h, after the elution is completed, collect the eluent and add mass fraction 5% chitosan solution to the eluent at a mass ratio of 1:8 , stirred and mixed and placed under 200W for ultrasonic dispersion for 10 minutes to obtain a dispersion; in parts by weight, weigh 45 parts of deionized water, 3 parts of glacial acetic acid, and 6 parts of nano-h...

Example Embodiment

[0017] Example 2

[0018] Take pig tooth soap and vacuum freeze-dry, pulverize and pass through a 200-mesh sieve to obtain a sieved powder and add the sieved powder to a 55% ethanol solution by mass fraction, stir and mix, and place in a water bath at 67°C Heating for 2 hours, standing to cool to room temperature, filtering and collecting the filtrate, and rotating the filtrate at 57°C to 1 / 5 of the original volume to obtain a rotary evaporation liquid and adding it to a macroporous adsorption resin column, and then using a mass fraction of 30 % ethanol solution elution treatment, control the elution rate of ethanol solution to 2BV / h, after the elution is completed, collect the eluent and add mass fraction 5% chitosan solution to the eluent at a mass ratio of 1:8 , stirred and mixed and placed under 250W for ultrasonic dispersion for 12 minutes to obtain a dispersion; in parts by weight, weigh 47 parts of deionized water, 4 parts of glacial acetic acid, and 7 parts of nano-hyd...

Example Embodiment

[0019] Example 3

[0020] Take pig tooth soap and vacuum freeze-dry, crush and pass through a 200-mesh sieve to obtain a sieved powder and add the sieved powder to a 55% ethanol solution with a mass fraction of 1:10, stir and mix, and place in a water bath at 70°C Heating for 3 hours, standing to cool to room temperature, filtering and collecting the filtrate, and rotating the filtrate at 60°C to 1 / 5 of the original volume to obtain the rotary evaporation liquid and adding it to a macroporous adsorption resin column, and then using a mass fraction of 30 % ethanol solution elution treatment, control the elution rate of ethanol solution to 2BV / h, after the elution is completed, collect the eluent and add mass fraction 5% chitosan solution to the eluent at a mass ratio of 1:8 , stirred and mixed and placed under 300W for ultrasonic dispersion for 15 minutes to obtain a dispersion; in terms of parts by weight, weigh 50 parts of deionized water, 5 parts of glacial acetic acid, and ...

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PUM

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Abstract

The invention relates to a preparation method of an anti-migration protein transportation carrier material and belongs to the technical field of medical materials. According to the technical scheme, arice alcohol-soluble protein is adopted as a main carrier body and has good biocompatibility and bio-adhesion, so that a hydrophilic area and a hydrophobic area in a molecular structure of the protein are distinguished obviously, and the protein is similar to a segmented copolymer, has unique self-assembly characteristics, is more resistant to digestion than a common protein and has specific binding capacity with a hydrophobic active substance, thereby being capable of serving as a good bioactive substance transportation carrier; meanwhile, according to the technical scheme, the protein is mixed with hydroxyapatite for preparing of the material, so that stability of the material is effectively improved, a target object is not damaged, the retention time of the target object in the digestive tract is prolonged, and the acting duration of the material is prolonged.

Description

technical field [0001] The invention relates to a preparation method of an anti-migration protein transport carrier material, which belongs to the technical field of medical materials. Background technique [0002] Protein is the most promising matrix for the preparation of biologically active substance delivery carriers, and solvent evaporation and anti-solvent methods are currently commonly used methods for preparing nanoparticles. Zein has good biocompatibility and bioadhesion, and its molecular structure has obvious divisions between hydrophilic regions and hydrophobic regions, similar to block copolymers, and has unique self-assembly characteristics, which are more durable than ordinary proteins. Digestion, has specific binding ability with hydrophobic active substances, and can be used as a good delivery carrier for biological active substances. Both anti-solvent and solvent evaporation methods can induce zein to self-assemble. However, due to the hydrophobicity of z...

Claims

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Application Information

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IPC IPC(8): A61K36/483A61K47/42A61K47/02A61K47/36
CPCA61K36/483A61K47/02A61K47/36A61K47/42
Inventor 姜香韩桂林
Owner 姜香
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