Synthesis method of N-benzyl-alpha-methylbenzylamine

Abstract

The invention discloses a synthesis method of N-benzyl-alpha-methylbenzylamine. According to the method, phenylethylamine, benzaldehyde, KBH4, (NH4)2Mo7O24, Ni(NO3)2, 4,4'-dipyridyl, urea formaldehyderesin and H3PMo12O40 are used as main raw materials. The synthesis method is used for carrying out nucleophilic addition through phenylethylamine and benzaldehyde under the action of a catalyst whichis P-Mo2Ni / NC and then further reducing to obtain N-benzyl-alpha-methylbenzylamine. Compared with the conventional synthesis method, the synthesis method has the advantages that limited carbonizationof polyacids is capable of effectively avoiding excessive growth of metal carbide particles; nano-sized monodispersed catalyst particles can be obtained; racemization is not generated when KBH4 is used as a reducing agent for reducing intermediate products which are imine materials; and phenylethylamine with two configurations and extremely high optical purity can be easily obtained.

Description

technical field [0001] The invention relates to a method for synthesizing N-benzylphenethylamine, which belongs to the field of chemical synthesis. Background technique [0002] N-Benzylphenylethylamine (N-Benzyl-α-methylbenzylamine) CAS: 38235-77-7 is a resolving agent with a wide range of uses and high stereoselectivity, and it is also a catalyst ligand for asymmetric reactions . As a resolving agent, it can well split the precursor o-chloromandelic acid of the new drug for the treatment of cardiovascular disease Yorkrapidol, and the precursor β-hydroxycarboxylic acid of the HIV protease inhibitor of the AIDS drug; as a ligand, it can occur The asymmetric Michael addition reaction with lithium and magnesium as the catalyst, and the asymmetric deprotonation reduction reaction of chiral ketones are mainly used in the aldehyde-ketone condensation reaction. The main preparation method is that under the catalysis of the metal ligand of metal iridium or zirconium, the racemic ...

AI Technical Summary

Problems solved by technology

The main preparation method is that under the catalysis of the metal ligand of metal iridium or zirconium, the racemic imine undergoes an asymmetric hydrogenation reduction reaction. This method must use rare metal iridium or zirconium; NaBH 3 CN is a reducing agent to reduce imines, but the yield is only 60%, and racemization occurs during the reaction, which is unavoidable; traditional synthesis methods have limitations in the use of catalysts or operating pressure, and the yield of products is low Difficult to use in production and lab