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Biodegradable graphene oxide composite fiber membrane and preparation method and application thereof

A graphene composite and biodegradable technology, which is applied in drug delivery, pharmaceutical formulation, textiles and papermaking, etc., can solve the problem of materials lacking antibacterial, biocompatibility and biodegradable composite functions, biodegradable medical There are not many researches on materials, etc., to achieve the effects of excellent biodegradability, low cytotoxicity, and high hygroscopicity

Active Publication Date: 2018-10-30
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, regarding the application of GO in medical materials, especially in medical dressings, there are not many studies on making GO into biodegradable medical materials, and generally focus on its bacteriostasis and mechanical properties. In terms of functional improvement, there is a lack of materials with composite functions such as antibacterial, biocompatibility, and biodegradability

Method used

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  • Biodegradable graphene oxide composite fiber membrane and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0025] A biodegradable graphene oxide composite fiber membrane, consisting of an outer layer and an inner layer, the outer layer is a biodegradable polymer nanofiber modified by graphene oxide, and the inner layer is a sodium alginate / polyvinyl alcohol nanocomposite fiber . The mass ratio of graphene oxide and biodegradable polymer in the graphene oxide modified biodegradable polymer nanofiber is 1:25. The biodegradable polymer is polylactic acid (PLA). The percentage of sodium alginate in the sodium alginate / polyvinyl alcohol nanocomposite fiber to the total mass of sodium alginate and polyvinyl alcohol is 10 wt%.

[0026] The preparation method of this biodegradable graphene oxide composite fiber membrane is as follows:

[0027] (1) Firstly, graphene oxide was prepared by the Hummers method, and 1 g of graphene oxide powder was weighed, and 20 ml of N,N-dimethylformamide was added, ultrasonicated for 30 minutes to form a uniform graphene oxide solution; 25 g of polylactic ...

Embodiment 2

[0033] A biodegradable graphene oxide composite fiber membrane, consisting of an outer layer and an inner layer, the outer layer is a biodegradable polymer nanofiber modified by graphene oxide, and the inner layer is a sodium alginate / polyvinyl alcohol nanocomposite fiber . The mass ratio of graphene oxide and biodegradable polymer in the graphene oxide modified biodegradable polymer nanofiber is 1:100. The biodegradable polymer is polyglycolic acid (PGA). The percentage of sodium alginate in the sodium alginate / polyvinyl alcohol nanocomposite fiber to the total mass of sodium alginate and polyvinyl alcohol is 40wt%.

[0034] The preparation method of this biodegradable graphene oxide composite fiber membrane is as follows:

[0035] (1) First prepare graphene oxide by Hummers method, weigh 1g of graphene oxide powder, add 20ml of absolute ethanol, and ultrasonicate for 30min to form a uniform graphene oxide solution; weigh 100g of polyglycolic acid, add 200ml of chloroform ...

Embodiment 3

[0041] A biodegradable graphene oxide composite fiber membrane, consisting of an outer layer and an inner layer, the outer layer is a biodegradable polymer nanofiber modified by graphene oxide, and the inner layer is a sodium alginate / polyvinyl alcohol nanocomposite fiber . The mass ratio of graphene oxide and biodegradable polymer in the graphene oxide modified biodegradable polymer nanofiber is 1:100. The biodegradable polymer is polycaprolactone (PCL). The percentage of sodium alginate in the sodium alginate / polyvinyl alcohol nanocomposite fiber to the total mass of sodium alginate and polyvinyl alcohol is 10 wt%.

[0042] The preparation method of this biodegradable graphene oxide composite fiber membrane is as follows:

[0043] (1) First, prepare graphene oxide by Hummers method, weigh 1g of graphene oxide powder, add 20ml of absolute ethanol, and ultrasonicate for 30min to form a uniform graphene oxide solution; weigh 100g of polycaprolactone, add 200ml of dichloro me...

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Abstract

The invention provides a biodegradable graphene oxide composite fiber membrane which is composed of an outer layer and an inner layer. The outer layer is biodegradable polymer nanofiber modified by graphene oxide, and the inner layer is sodium alginate / polyvinyl alcohol nano composite fiber. The invention further provides a preparation method of the biodegradable graphene oxide composite fiber membrane. The preparation method includes: preparing and crosslinking inner and outer layer electrostatic spinning liquid. The composite fiber membrane can serve as a medical dressing, a surgical sutureor a drug carrier material. The technical problem that materials have composite functions of being bacteriostatic, biocompatible and biodegradable are insufficient is solved, and a composite materialhaving high biocompatibility, biodegradability and bacteriostatic ability and good mechanical performance.

Description

technical field [0001] The invention relates to the field of biological materials, and relates to a composite fiber membrane and its preparation method and application, in particular to a biodegradable graphene oxide composite fiber membrane and its preparation method and application. Background technique [0002] Graphene is the thinnest material known to man, a million times thinner than a human hair. Graphene oxide (GO) is again an atomic-scale material composed only of carbon and oxygen atoms. Currently, GO is being investigated for use in several fields including drug delivery and other medical applications. [0003] At present, regarding the application of GO in medical materials, especially in medical dressings, there are not many studies on making GO into biodegradable medical materials, and generally focus on its bacteriostasis and mechanical properties. In terms of functional improvement, there is a lack of materials with composite functions such as antibacterial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/62A61L15/64A61L15/28A61L15/26A61L15/42A61L15/46A61L15/24A61L17/00A61L17/12A61L17/10A61K47/04A61K47/36A61K47/32A61K47/34D04H1/728
CPCA61K47/02A61K47/32A61K47/34A61K47/36A61L15/18A61L15/24A61L15/26A61L15/28A61L15/42A61L15/46A61L15/62A61L15/64A61L17/005A61L17/105A61L17/12A61L2300/232A61L2300/404A61L2400/04D04H1/728C08L5/04C08L29/04C08L67/04
Inventor 赵立春唐农冷静宋策钟余特于培良王雪
Owner GUANGXI UNIV OF CHINESE MEDICINE