PVA hydrogel, composite material using same and preparation method and application of PVA hydrogel

A composite material and hydrogel technology, applied in pharmaceutical formulations, catheters, medical science and other directions, can solve the problems of poor mechanical properties and complex preparation process, and achieve the effect of simple manufacturing process and excellent mechanical properties

Active Publication Date: 2018-10-30
HUZHOU SIMAN BIOLOGICAL MATERIAL CO LTD +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the PVA hydrogel prepared by the above-mentioned conventional method (hereinafter referred to as conventional PVA hydrogel) has defects such as relatively poor mechanical properties and complicated preparation process. People expect to develop a method that can be prepared in a simple manner. PVA hydrogel with excellent performance makes PVA hydrogel more suitable for application in implantable electronics, nanomedicine, minimally invasive technology, and biomedicine

Method used

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  • PVA hydrogel, composite material using same and preparation method and application of PVA hydrogel
  • PVA hydrogel, composite material using same and preparation method and application of PVA hydrogel
  • PVA hydrogel, composite material using same and preparation method and application of PVA hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0060] A viscous solution of PVA was formed by dissolving PVA with a molecular weight of 205,000 in distilled water to make 10% PVA (100 mg / mL; 10 g of PVA in 100 ml of distilled water) and placing in a shaking bath heated at 60°C overnight. Then pour 20ml of 10% PVA solution into a glass dish with a diameter of 10cm, dry it overnight at room temperature, then immerse it in a NaOH solution with a molar concentration of 1M for 10-20 minutes, wash it with pure water after gelation, and wash it Drain and store in airtight.

Embodiment 2

[0062] The PVA hydrogel was prepared using the same method as in Example 1, except that the concentration of NaOH was changed to 3M.

Embodiment 3

[0064] The PVA hydrogel was prepared using the same method as in Example 1, except that the concentration of NaOH was changed to 5M.

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Abstract

The invention provides PVA hydrogel and a composite material based on the PVA hydrogel. The PVA hydrogel is excellent in mechanical performance, shape memory performance, hydrophilcity and biocompatibility and has 3D printability and injectability. The invention further provides a novel method for preparing the PVA hydrogel and application of the PVA hydrogel in various fields such as catheters, 3D printable solutions, injectable electronic devices, microfluid channels, biological absorbable sensors, miniature robots, scaffolds for tissue engineering, surgical suture lines, medical gloves andcondoms.

Description

technical field [0001] The present invention relates to a polyvinyl alcohol (PVA) hydrogel, a composite material based on the PVA hydrogel, a method for manufacturing the PVA hydrogel and applications of the PVA hydrogel. Background technique [0002] Polyvinyl alcohol (PVA) is one of the most important synthetic polymers composed of carbon, oxygen, and hydrogen atoms, and is biodegradable under both aerobic and anaerobic conditions, and is widely used in commerce, industry, medicine, and nutraceuticals field. PVA can be easily dissolved in water. Currently, PVA hydrogels are generally synthesized by two common mechanisms, including chemical bonding using cross-linking agents such as glutamate and / or physical means such as freezing and thawing. PVA is very important for biomedicine, tissue engineering and soft robotics applications. [0003] At present, the PVA hydrogel prepared by the above-mentioned conventional method (hereinafter referred to as conventional PVA hydrog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J5/18C08L29/04C08K7/24C08K3/04C08K5/21A61L27/16A61L27/52A61L27/50A61L29/14A61L29/04A61L17/00A61L31/14A61L31/04
CPCA61L17/00A61L27/16A61L27/50A61L27/52A61L29/041A61L29/14A61L29/145A61L31/048A61L31/14A61L31/145C08J3/075C08J5/18A61L2400/16A61L2400/06C08K3/042C08K3/041C08K2201/011C08K2201/01C08K5/21C08J2329/04C08L29/04
Inventor 邢孟秋吴军叶海雁刘抗邱佩琪
Owner HUZHOU SIMAN BIOLOGICAL MATERIAL CO LTD
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