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Azithromycin injection for veterinary use

A technology of azithromycin and injection, applied in the field of medicinal chemistry, can solve the problems of strong irritation, easy infusion reaction, poor compliance, etc., and achieve the effect of less irritation, favorable application and long acting time

Inactive Publication Date: 2018-11-02
东莞市东阳光动物保健药品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Azithromycin intravenous infusion is highly irritating and prone to infusion reactions
Therefore, if these dosage forms are used for animals, there are often many inconveniences, such as strong irritation, repeated administration, and poor compliance.

Method used

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  • Azithromycin injection for veterinary use
  • Azithromycin injection for veterinary use
  • Azithromycin injection for veterinary use

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0019] The preparation method of the aforementioned solution-type injection may include the following steps: dissolving the prescribed amount of active pharmaceutical ingredients in diethylene glycol monoethyl ether, stirring and dissolving; subpackaging, plugging, capping, and packaging.

[0020] On the other hand, the veterinary azithromycin injection provided by the present invention can be a lyophilized injection.

[0021] The freeze-dried injection includes active pharmaceutical ingredients and sodium deoxycholate, wherein the active pharmaceutical ingredients are as defined above.

[0022] The particle size of the active pharmaceutical ingredient of the freeze-dried injection has the following characteristics: its D50 is 1 μm-10 μm, and its D90 is 3 μm-15 μm. In some embodiments, the particle size of the active pharmaceutical ingredient of the freeze-dried powder has the following characteristics: its D50 is 4 μm-6 μm, and its D90 is 9 μm-12 μm. Too large particle size ...

specific Embodiment approach

[0037] In order to enable those skilled in the art to better understand the technical solutions of the present invention, some non-limiting examples are further disclosed below to further describe the present invention in detail.

[0038] The reagents used in the present invention can be purchased from the market or can be prepared by the methods described in the present invention. The source of Diethylene Glycol Monoethyl Ether (Transcutol V) is Jaffa Lion, and "V" is the model number, representing veterinary use.

[0039] In the present invention, kg: kilogram; g: gram; mg: milligram; ng: nanogram; mL: milliliter; min: minute; h: hour; q.s.: constant volume; PEG: polyethylene glycol; AUC: drug-time curve Cmax: peak concentration; Tmax: peak time; MIC: minimum inhibitory concentration; SD: standard deviation; CV: coefficient of variation; The area under the drug-time curve is calculated by the corresponding software.

[0040] Freeze-drying method and conditions of the prese...

Embodiment 1

[0042] Preparation of Comparative Example 1 Azithromycin Injection Suspension

[0043] To prepare azithromycin injection suspension, the prescription is as follows:

[0044]

[0045] Preparation method: Add azithromycin dihydrate and sodium deoxycholate to water for injection, grind for 15 minutes with a ball mill, adjust the pH value to 8.55 with hydrochloric acid, absorb the suspension for injection, and freeze-dry it with a vacuum freeze dryer to obtain a freeze-dried powder. The lyophilized powder is reconstituted with a certain amount of 5% glucose to obtain an injection suspension.

[0046] The resulting suspension was detected, and the particle size of the active ingredient in the suspension was measured as D50 of 5.77 μm and D90 of 11.9 μm; the suspension had a uniform appearance, good fluidity, slow settling, and good redispersibility. Non-stick to the wall, good needle penetration, suitable for injection. After the lyophilized powder is reconstituted with 5% glu...

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PUM

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Abstract

The invention provides an azithromycin injection for veterinary use and belongs to the field of medicinal chemistry. The injection disclosed by the invention contains an active ingredient and an injection solvent diethylene glycol monoethyl ether, and the bioactive component or active ingredient can be released within 1-14 days; and the action time is long, the administration frequency can be decreased, irritation and edema conditions can be reduced to a certain degree, the usage compliance is increased, and the preparation process is simple, easy to operate and stable in quality and is favorable for application.

Description

technical field [0001] The invention relates to a veterinary azithromycin injection, in particular to a veterinary azithromycin injection for treating livestock and poultry infections, and belongs to the field of medicinal chemistry. Background technique [0002] Azithromycin, a macrolide antibiotic, can be used for skin infections and respiratory tract infections caused by bacteria such as Chlamydia pneumoniae, Haemophilus influenzae, Legionella pneumophila, Moraxella catarrhalis, Staphylococcus aureus or Streptococcus pneumoniae , Urogenital system infection and other infections, it is one of the commonly used antibacterial drugs in clinical practice. In the animal kingdom, such as poultry and livestock, azithromycin also has a wide range of antibacterial effects, but there is currently no special azithromycin veterinary preparation, and the dosage forms of azithromycin for humans that have been marketed are mainly tablets and injections, and the injections are mainly intr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61K31/7052A61K47/10A61P31/04
CPCA61K9/0019A61K9/08A61K9/19A61K31/7052A61K47/10A61P31/04
Inventor 宋美芸邢伟牛秀会赵步文齐宜广游劲松黄芳芳
Owner 东莞市东阳光动物保健药品有限公司
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