A kind of solid pharmaceutical composition containing trimetazidine or its salt and its preparation method

A composition and drug technology, applied in the field of trimetazidine solid pharmaceutical compositions, can solve the problems of poor particle fluidity, unfavorable patients, increase in impurities and the like
CN108721235BActive Publication Date: 2021-07-02JIANGSU HENGRUI MEDICINE CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU HENGRUI MEDICINE CO LTD
Publication Date
2021-07-02

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Abstract

The invention relates to a solid pharmaceutical composition containing trimetazidine or a salt thereof and a preparation method thereof. Specifically, the solid pharmaceutical composition of the present invention contains trimetazidine or a pharmaceutically acceptable salt or a solvate thereof as an active ingredient, and two or more sustained-release matrix materials. The solid pharmaceutical composition of the present invention has the characteristics of gentle release over a long period of time.
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Description

technical field

[0001] The invention relates to a trimetazidine solid pharmaceutical composition capable of slow and stable release and a preparation method thereof. The composition is used for preventive treatment of angina pectoris attacks. Background technique

[0002] Trimetazidine, whose chemical name is 1-(2,3,4-trimethoxybenzyl)piperazine, has the following structure:

[0003]

[0004] Normal myocardial energy (ATP) supply 60% to 70% from free fatty acid β oxidation, 20% to 25% from glucose oxidation, 5% to 10% from glycolysis. The oxygen consumption of free fatty acid oxidation to produce the same amount of ATP is higher than that of glucose oxidation, and high levels of free fatty acid oxidation can significantly inhibit the rate of glucose oxidation. During myocardial ischemia, the sympathetic nerve is excited, and the level of catecholamines increases, which in turn leads to an increase in the level of free fatty acids in the blood; the oxidation of free fatty...

Claims

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