Preparation method capable of improving taste and curative effect of bezoar disintoxicating buccal tablet
A technology to improve curative effect and bezoar detoxification, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, active ingredients of hydroxyl compounds, etc., and can solve the problems that patients with odor are difficult to accept
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Embodiment 1
[0008] Step 1. Take the crushed rhubarb medicinal powder, add 50%-90% ethanol to soak it, reflux extraction, filter, after the filtrate is evaporated to dryness under reduced pressure, add 0.1%-10% hydrochloric acid solution, heat and reflux for 0.5h-5h , extracted with chloroform, and dried under reduced pressure to obtain a mixture of rhubarb monomer components.
[0009] Step 2. Grind the artificial bezoar into fine powder, pass through a 100-mesh sieve, and collect the powder.
[0010] Step 3. The realgar water is prepared into a very fine powder by water flying method, and the powder is collected.
[0011] Step 4. Dissolve the above powder in water to form a solution or suspension, add 1% sodium alginate solution, and stir to form a solution.
[0012] Step 5. Drop the above solution into 1-5% Ca 2+ In the example solution, after 2-3 hours of calcification, the homogeneous machine is dispersed to form microcapsules, and the microcapsule powder is collected by filtration. ...
Embodiment 2
[0019] Step 1. Take the crushed rhubarb medicinal powder, add 50%-90% ethanol to soak it, reflux extraction, filter, after the filtrate is evaporated to dryness under reduced pressure, add 0.1%-10% hydrochloric acid solution, heat and reflux for 0.5h-5h , extracted with chloroform, and dried under reduced pressure to obtain a mixture of rhubarb monomer components.
[0020] Step 2. Grind the artificial bezoar into fine powder, pass through a 100-mesh sieve, and collect the powder.
[0021] Step 3. The realgar water is prepared into a very fine powder by water flying method, and the powder is collected.
[0022] Step 4. The above powders are combined and dissolved in water to form a solution or a suspension, and then added to a 1% gelatin and gum arabic solution with a pH value of 8.0, and stirred to form a solution.
[0023] Step 5. Under magnetic stirring, adjust the pH of the above solution to about 4.0 with 1% hydrochloric acid to form microcapsules.
[0024] Step 6. Drop ...
Embodiment 3
[0031] Step 1. Take the crushed rhubarb medicinal powder, add 50%-90% ethanol to soak it, reflux extraction, filter, after the filtrate is evaporated to dryness under reduced pressure, add 0.1%-10% hydrochloric acid solution, heat and reflux for 0.5h-5h , extracted with chloroform, and dried under reduced pressure to obtain a mixture of rhubarb monomer components.
[0032] Step 2. After the mixture of rhubarb monomer components is clathrated with saturated β-cyclodextrin, the clathrate of β-cyclodextrin is prepared and placed in an oven at 60° C. for drying.
[0033] Step 3. Grind the artificial bezoar, pass through a 100-mesh sieve, and collect the powder.
[0034] Step 4. The realgar water is prepared by a water-flying method to prepare a very fine powder, and the powder is collected.
[0035] Step 5. Combine and dissolve the above powders in water to form a solution or suspension, add pregelatinized starch and hydroxypropyl methylcellulose, and stir to form a solution.
...
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