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A kind of compound amino acid vitamin injection and application thereof

A compound amino acid and injection technology, applied in the field of biomedicine, to achieve the effects of inhibiting catabolism, high utilization rate, and promoting anabolism

Active Publication Date: 2021-09-21
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report about the compound amino acid vitamin injection of the present invention aimed at the material and energy metabolism characteristics of the perioperative anesthesia period and high utilization rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 compound amino acid vitamin injection (one)

[0053] Compound amino acid vitamin injection (per 1000ml) includes: L-leucine: 20.6g, L-isoleucine: 12.2g, L-valine: 15.2g, L-alanyl-L-glutamine : 25g, L-threonine: 2g, L-lysine (acetate): 3.8g, L-methionine: 3g, L-phenylalanine: 2.8g, L-tryptophan: 1g, L -Arginine: 12g, L-histidine: 2.4g, vitamin B6: 10mg, sodium bisulfite 0.5g, adjust the pH value to 5.5-6.5 with glacial acetic acid, add water for injection to a total of 1000ml. Method of use: 4-8kJ·kg during the operation -1 h -1 Intravenous infusion, according to daily 1.2-2.0g / kg intravenous infusion after operation.

Embodiment 2

[0054] Embodiment 2 compound amino acid vitamin injection (two)

[0055] L-leucine: 40g, L-isoleucine: 30g, L-valine: 30g, L-alanyl-L-glutamine: 10g, L-threonine: 5g, L-lysine Amino acid (acetate): 5g, L-methionine: 2g, L-phenylalanine: 3g, L-tryptophan: 0.5g, L-arginine: 5g, L-histidine: 1g, Vitamin B6: 1mg, Vitamin B1: 1mg, Vitamin B12: 100μg, Sodium bisulfite 0.3g, Na + 10mmol / L, Cl - 10mmol / L, adjust the pH value to 5.5-7.0 with glacial acetic acid, add water for injection to a total of 1000ml. Method of use: 4-8kJ·kg during the operation -1 h -1 Intravenous infusion, according to daily 1.2-2.0g / kg intravenous infusion after operation.

Embodiment 3

[0056] Embodiment 3 compound amino acid vitamin injection (three)

[0057] L-leucine: 5g, L-isoleucine: 2g, L-valine: 2g, L-alanyl-L-glutamine: 5g, L-threonine: 1g, L-lysine Amino acid (acetate): 1g, L-methionine: 1g, L-phenylalanine: 1g, L-tryptophan: 8g, L-arginine: 30g, L-histidine: 10g, vitamin B6: 8mg, vitamin B1: 10mg, vitamin B12: 100μg, sodium bisulfite 0.8g, Na + 80mmol / L, Cl - 80mmol / L, adjust the pH value to 5.5-7.0 with glacial acetic acid, add water for injection to a total of 1000ml. Method of use: 4-8kJ·kg during the operation -1 h -1 Intravenous infusion, according to daily 1.2-2.0g / kg intravenous infusion after operation.

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PUM

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Abstract

The invention discloses a compound amino acid vitamin injection and its application. Each 1000ml contains: L-leucine: 5-40g, L-isoleucine: 2-30g, L-valine: 2-30g, L-Alanyl-L-Glutamine: 5-90g, L-Threonine: 1-5g, L-Lysine: 1-10g, L-Methionine: 1-12g, L-Phenylalanine : 1-10g, L-Tryptophan: 0.5-8g, L-Arginine: 2-30g, L-Histidine: 1-10g, Vitamin B6: 1-100mg, Vitamin B1: 0-50mg, vitamin B12: 0-100 μg. The invention aims at the changes of stress, immunity and metabolism in the perioperative anesthesia period of the human body, responds to the concept of accelerated recovery surgery with an innovative formula, inhibits catabolism, promotes anabolism, produces heat and keeps warm, and improves the body's material energy metabolism and immune function , for the purpose of accelerating recovery.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a compound amino acid vitamin injection and its application. Background technique [0002] In the past, the infusion of energy substances (amino acids, fats) other than glucose was considered only when the patient was still unable to eat effectively during the perioperative period. In 2003, the inventor carried out the infusion of compound amino acids during anesthesia Afterwards, the clinical effects of various formula amino acids were studied, and it was found that proper infusion of compound amino acid injection during surgical anesthesia can inhibit the decomposition of skeletal muscle protein, promote its synthesis, inhibit fat mobilization, improve hypothermia caused by surgical anesthesia, and correct Negative nitrogen balance, no obvious side effects, no damage to liver and kidney functions, and can be safely used in diabetic patients. However, currently commercially...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/05A61K9/08A61P3/02A61P37/04A61P39/00A61K31/198A61K31/405A61K31/4172A61K31/4415A61K31/51A61K31/714A61K33/04
CPCA61K9/0019A61K9/08A61K31/198A61K31/405A61K31/4172A61K31/4415A61K31/51A61K31/714A61K33/04A61K38/05A61P3/02A61P37/04A61P39/00A61K2300/00
Inventor 葛圣金
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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