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Application of flexible transparent carbon nano tube neural electrode array in neural photoelectric interface

An electrode array, carbon nanotube film technology, applied in the field of materials, to achieve the effects of favorable signal-to-noise ratio, high light transmittance, superior flexibility and extensibility

Active Publication Date: 2018-11-06
PEKING UNIV
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AI Technical Summary

Problems solved by technology

In basic research, due to the huge amount of information in neural activities, it is necessary to collect information with high temporal / spatial resolution at the same time, and a single electrical recording technology or optical imaging technology cannot meet the requirements. Scientific research is of great significance

Method used

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  • Application of flexible transparent carbon nano tube neural electrode array in neural photoelectric interface
  • Application of flexible transparent carbon nano tube neural electrode array in neural photoelectric interface
  • Application of flexible transparent carbon nano tube neural electrode array in neural photoelectric interface

Examples

Experimental program
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Embodiment 1

[0053] Example 1, Application of Carbon Nanotube Films in the Preparation of Mechanically Active Nervous System Devices

[0054] 1) Characterization of carbon nanotube film electrode properties

[0055] We characterize the CNT thin film electrode array from two aspects of electrical properties and mechanical properties. In terms of electrical properties, in order to preliminarily measure the electrical properties of microelectrode arrays in biological fluids, we first simulated the body fluid environment with phosphate buffer saline (PBS), and measured the microelectrode arrays in the electrolyte solution using a standardized three-point test method. Impedance of the electrode array at different frequencies. The so-called three-point test method is to use Ag / AgCl as a reference electrode, platinum wire as a counter electrode, and a microelectrode array as a working electrode to measure its electrochemical impedance spectroscopy (EIS).

[0056] The result obtained is as ima...

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Abstract

The present invention discloses an application of a flexible transparent carbon nano tube neural electrode array in a neural photoelectric interface. A flexible transparent carbon nano has a high light transmittance in a wide wavelength interval and can still maintain good electrochemical properties and optical properties in a stretching state to achieve simultaneous recording of cortex epilepsy electrophysiological signals and two-photon calcium imaging and real-time recording of brain electricity in the photostimulation so as to observe the nerve motion with high time / spatial resolution. Thegood flexibility and the extensibility of the carbon nano tube electrode array are employed and the flexible transparent carbon nano tube neural electrode array can be used for real-time monitoring of the brain electricity motion in the brain damaging; and moreover, the carbon nano tube neural electrode array can be perfectly fit with a tissue to form an efficient brain / electronic interface and facilitate improving of the signal to noise ratio. The results above all show the huge utilization potentiality of the carbon nano tube neural electrode array in a nervous system especially in a mechanical active system electro-optic interface.

Description

technical field [0001] The invention belongs to the field of materials, and relates to the application of a flexible transparent carbon nanotube nerve electrode array in a nerve electro-optical interface. Background technique [0002] In the research and application of modern biomedicine, the neural interface that connects the neural tissue with the in vitro environment plays an important role. In basic research, due to the huge amount of information in neural activities, it is necessary to collect information with high temporal / spatial resolution at the same time, and a single electrical recording technology or optical imaging technology cannot meet the requirements. Scientific research is of great significance. In addition, the emergence of optogenetic technology provides more possibilities for precise control of neurons, and has penetrated into every corner of neuroscience. Researchers not only use it to study the basic functions of the brain, but also explore the pathog...

Claims

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Application Information

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IPC IPC(8): A61N1/05A61N1/36
CPCA61N1/0529A61N1/0551A61N1/36064
Inventor 段小洁曹安源张菁徐文静刘小军楚芳冰
Owner PEKING UNIV
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