Preparation method for multilayer composite photosensitive artificial skin sensor

A technology of artificial skin and multi-layer composite, applied in the fields of medical formula, medical science, prosthesis, etc., can solve the problems of lack of natural skin tactile feeling and signal transmission function, physical and mechanical properties that do not meet the use requirements, complex production, etc. Achieving good external force response, improving poor mechanical properties, and less environmental pollution

Inactive Publication Date: 2018-11-20
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the artificial skin successfully developed and applied mainly plays a role of covering the subcutaneous tissue to a certain extent, provides a composite material scaffold to promote the growth of wound epidermal cells, or has some slow-release drug factors that can promote skin growth. This type of artificial skin has good Biocompatibility, physical and mechanical properties and medical performance, but its production is complicated, costly and does not have the tactile sensation and signal transmission function of natural skin
[0003] The artificial skin sensor is a film-like composite material that adds external stimulus perception and electrical signal transmission functions to the original artificial skin. This type of sensor has a certain perception function for changes and stimuli in the external environment. For example, a temperature sensor can sense The change of skin temperature and the tactile sensor can sense the deformation of the skin under the action of external force, but the common problem with artificial skin sensors is that the physical and mechanical properties do not meet the requirements for use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A method for preparing a multilayer composite photosensitive artificial skin sensor, comprising the following preparation steps:

[0030] Step 1): adding the graphene after grinding and pulverizing into the HI / HAC solution for dispersion, preparing a graphene HI / HAC solution with a concentration of 0.1 g / ml, and freeze-drying the graphene HI / HAC solution, wherein The molar concentrations of HI and HAC in the HI / HAC solution are both 0.1mol / L;

[0031] Step 2): put the freeze-dried sample into toluene and sonicate for 1 hour to obtain a broken graphene sponge, place the graphene sponge in a centrifuge with a speed of 3000rmp, and wash it twice with deionized water, each time Wash for 2 minutes;

[0032] Step 4): Centrifuge the mixed solution A after the oil bath reaction in step 3), take the precipitate, and use absolute ethanol and deionized water to wash centrifugally respectively to obtain the graphene oxide-silver nanocomposite material, and the graphene oxide - ad...

Embodiment 2

[0040] A method for preparing a multilayer composite photosensitive artificial skin sensor, comprising the following preparation steps:

[0041] Step 1): adding the graphene after grinding and pulverizing into the HI / HAC solution for dispersion, preparing a graphene HI / HAC solution with a concentration of 0.3g / ml, and freeze-drying the graphene HI / HAC solution, wherein The molar concentrations of HI and HAC in the HI / HAC solution are both 0.5mol / L;

[0042] Step 2): Put the freeze-dried sample into toluene and sonicate for 2.5 hours to obtain a broken graphene sponge, place the graphene sponge in a centrifuge at a speed of 5500rmp, and centrifugally wash it with deionized water 4 times. Wash for 4 minutes;

[0043] Step 4): Centrifuge the mixed solution A after the oil bath reaction in step 3), take the precipitate, and use absolute ethanol and deionized water to wash centrifugally respectively to obtain the graphene oxide-silver nanocomposite material, and the graphene oxide...

Embodiment 3

[0051] A method for preparing a multilayer composite photosensitive artificial skin sensor, comprising the following preparation steps:

[0052] Step 1): adding the graphene after grinding and pulverizing into the HI / HAC solution for dispersion, preparing a graphene HI / HAC solution with a concentration of 0.5g / ml, and freeze-drying the graphene HI / HAC solution, wherein The molar concentrations of HI and HAC in the HI / HAC solution are both 1mol / L;

[0053] Step 2): Put the freeze-dried sample into toluene for 4 hours of supersonication to obtain a broken graphene sponge, place the graphene sponge in a centrifuge with a rotation speed of 8000rmp, and centrifugally wash it with deionized water 5 times, each time Wash for 5 minutes;

[0054] Step 4): Centrifuge the mixed solution A after the oil bath reaction in step 3), take the precipitate, and use absolute ethanol and deionized water to wash centrifugally respectively to obtain the graphene oxide-silver nanocomposite material,...

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PUM

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Abstract

The invention discloses a preparation method for a multilayer composite photosensitive artificial skin sensor. Freeze drying can be performed on graphene after the graphene is treated by an HI/HAC solution; the graphene is put into toluene to perform treatment; an AgNO3 solution is added into an FGS water solution; a graphene-silver nanocomposite can be obtained after centrifugation and washing; asurfactant can be dropped into an oxidized graphene-silver nanocomposite dispersion liquid so that an azobenzene-oxidized graphene-silver nanocomposite aqueous solution can be prepared; anti-stick treatment can be performed on a substrate silicon; waste silk can be taken to perform degumming, heating and concentration can be performed, and silk fibroin can be applied on a silicon chip to performfilm forming; and film forming can be performed on the azobenzene-oxidized graphene-silver nanocomposite aqueous solution and PDMS in a spin-coating manner, so that the multilayer composite photosensitive artificial skin sensor can be obtained. The obtained artificial skin has a good biocompatibility function, physical and mechanical property and photoresponse performance, and resistance changes occur under certain external force and illumination.

Description

technical field [0001] The invention relates to a method for preparing a sensor, and more specifically, relates to a method for preparing a multilayer composite photosensitive artificial skin sensor. Background technique [0002] Artificial skin is a dressing used to treat skin wounds, which is mainly made of biomaterials or synthetic materials with good biocompatibility. Artificial skin has a good effect on scalds, burns and skin loss in the medical field, and can even be used as a substitute for natural skin in some cases. At present, the artificial skin successfully developed and applied mainly plays a role of covering the subcutaneous tissue to a certain extent, provides a composite material scaffold to promote the growth of wound epidermal cells, or has some slow-release drug factors that can promote skin growth. This type of artificial skin has good Biocompatibility, physical and mechanical properties and medical performance, but its production is complicated, the cos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/04A61L27/18A61L27/22A61L27/02A61L27/60A61L27/50
CPCA61L27/025A61L27/047A61L27/18A61L27/227A61L27/50A61L27/60A61L2400/12A61L2430/34C08L89/00C08L83/04
Inventor 万军民汪坚胡智文王秉彭志勤
Owner ZHEJIANG SCI-TECH UNIV
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