Biomedical electric activity water gel and preparation method thereof

Abstract

The invention discloses biomedical electric activity water gel and a preparation method thereof, and relates to the field of high molecular materials, in particular to the biomedical electric activitywater gel and the preparation method thereof. The biomedical electric activity water gel can be prepared by the method with steps of using natural and non-toxic compounds of glycine and choline to form ion liquid; then using acrylic acid to modify ion liquid; forming vinyl choline-glycine ion liquid monomers; using N, N-methylene bisacrylamide (MBAA) as crosslinking agents; using potassium peroxodisulfate (KPS) as initiators; preparing polyionic liquid gel through free radical polymerization; using the polyionic liquid gel as a first gel network; using American FDA authenticated polyethyleneglycol (PEG) as reaction monomers of a second gel network; using N, N-methylene bisacrylamide (MBAA) as the crosslinking agents; uisng potassium peroxodisulfate (KPS) as the initiators; forming the electric activity gel with the high mechanical strength with the first gel network. The gel has good biocompatibility and biodegradability and can be used in the fields of nerve tissue engineering, myocardiac tissue engineering and the like.

Description

technical field [0001] The invention relates to the field of tissue engineering biomaterials, in particular to a biomedical electroactive hydrogel and a preparation method thereof. Background technique [0002] Biomedical materials must adapt to the complex environment of organisms, so they need to have properties similar to natural materials in terms of biocompatibility and mechanical strength. Hydrogel has become an ideal substitute material because of its structure similar to human soft tissue, but its lack of mechanical strength has restricted its application for a long time. Taking articular cartilage as an example, it not only bears high pressure in human joints, but also absorbs impact energy from the outside world. However, once articular cartilage is damaged, it cannot be repaired with current medical technology. Therefore, to narrow the performance gap between polymer hydrogels and biological soft tissues, seek polymer hydrogel materials that match the properties ...

AI Technical Summary

Problems solved by technology

Hydrogel has become an ideal substitute material because of its structure similar to human soft tissue, but its lack of mechanical strength has restricted its application for a long time

Generally, a higher polymer content can improve the mechanical strength of the hydrogel, while a hydrogel with a lower polymer content often exhibits fluid properties; when the molecular chains constituting the hydrogel network are linear and neutral, the gel network has a higher High ductility and better energy dissipation, but lead to a decrease in the mechanical strength of the gel; hydrogels can form a network through chemical cross-linking and physical cross-linking, and the mechanical strength of chemically cross-linked hydrogels is often greater than that of physically cross-linked water Gel; no matter what kind of cross-linking method, increasing the degree of cross-linking can improve the mechanical strength of the hydrogel to a certain extent; in the process of cross-linking the hydrogel network, structural inhomogeneity often occurs. , this inhomogeneity can lead to stress concentration inside the gel, leading to the destruction of the gel structure