Preparation method of tablet containing grease components at high dosage

A high-dose, oil-ester technology, applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, and plant/algae/fungus/moss ingredients, etc., can solve the problem of low hardness, low tablet, tablet Fragmentation and edge knocking, etc., to achieve the effect of increasing hardness, improving brittleness and improving formability

Active Publication Date: 2018-11-30
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the raw material containing high-oil esters accounts for more than 15%, if it is made into a tablet, the hardness of the tablet is too low, and it is easy to cause tablet fragmentation and edge knocking. For example, the main raw material formula of phytosterol ester tablets is pow

Method used

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  • Preparation method of tablet containing grease components at high dosage

Examples

Experimental program
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Effect test

Example Embodiment

[0020] The present invention provides a specific method for preparing tablets containing high-dose oil ester ingredients. The specific steps include: adding oil ester active matter (the oil ester in the oil ester active matter accounts for 30%-50% by mass of the oil ester active matter) %) and the first part of silicon dioxide are put into the wet granulator, mixed until the color is uniform, while stirring, add povidone K30 aqueous solution or povidone K30 ethanol solution for granulation, the made soft material is over 16~ 20-mesh sieve, the sieved particles are dried in an oven at 40℃~45℃; after drying, use a 16-20 mesh sieve for granulation. After granulation, add the second part of silica, adsorbent and filler , Mix disintegrant and slippery material until the color is uniform. A rotary tablet press was used for tablet compression.

[0021] Among them, the oil ester active material is powder.

[0022] Specifically, the oil ester active material is powdered phytosterol ester....

Example Embodiment

[0027] Example 1

[0028] Put 30% by mass of phytosterol ester powder (wherein, the sterol ester accounts for 50% by mass of the phytosterol ester powder) and 1% by mass of silicon dioxide in the wet granulator, and add while stirring The povidone K30 aqueous solution with a mass percentage of 6% is granulated. The soft material made is passed through an 18-mesh sieve. The sieved granules are dried in an oven at 43°C. After drying until the granules contain 3% moisture, use 18 Mesh sieve for granulation; after granulation, 12% by mass of functional red yeast rice powder, 9.5% by mass of water-soluble tomato concentrate, 1% by mass of silica, and 20% by mass are added. Maltodextrin, 16% by mass microcrystalline cellulose, 4% by mass crospovidone, 0.5% by mass magnesium stearate, sample the prepared Example 1 to detect its disintegration Time limit, hardness, friability and tablet formability, the results are shown in Table 1.

Example Embodiment

[0029] Example 2

[0030] Put 30% by mass of phytosterol ester powder (where the sterol ester accounts for 50% by mass of the phytosterol ester powder) and 1% by mass of silicon dioxide in a wet granulator, and add while stirring The povidone K30 aqueous solution with a mass percentage of 6% is granulated. The soft material made is passed through an 18-mesh sieve. The sieved granules are dried in an oven at 43°C. After drying until the granules contain 3% moisture, use 18 Mesh sieve for sizing; after sizing, add 10% by mass functional red yeast rice powder, 7.5% by mass water-soluble tomato concentrate, 1% by mass silica, and 18% by mass Calcium hydrogen phosphate, 22% by mass of microcrystalline cellulose, 4% by mass of crospovidone, 0.5% by mass of magnesium stearate, sample the prepared Example 2 to detect its disintegration Time limit, hardness, friability and tablet formability, the results are shown in Table 1.

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Abstract

The invention belongs to the technical field of health-care products, and in particular relates to a preparation method of a tablet containing grease components at a high dosage. The preparation method of the tablet containing the grease components at a high dosage comprises the following steps: 1, mixing a grease active substance, a first part of silicon dioxide and a binding agent and implementing pelletizing, and implementing sieving and drying so as to obtain oil-containing granules, wherein in terms of mass percentage of the grease active substance, grease accounts for 30-50%; and 2, mixing the oil-containing granules, a second part of silicon dioxide, an adsorbent, a filling agent, a disintegrant, functional raw materials and a lubricating substance, and implementing tabletting, so that the tablet containing the grease components at the high dosage is prepared. According to the preparation method of the tablet containing the grease components at the high dosage, technical shortcomings of the prior art that it is difficult to conduct tabletting on grease components at a high dosage can be effectively overcome.

Description

technical field [0001] The invention belongs to the technical field of health care products, and in particular relates to a preparation method of a tablet containing high-dose oil and ester components. Background technique [0002] In tablet preparation technology, the targeted ingredients are generally non-oily solids. Because the existence of oily ingredients will lead to a series of problems in the process of tablet compression, such as: inability to form, split, low hardness of plain tablets, and inability to withstand coating operations, etc. Certainly, existing tablet technology still may be accomplished for some low-dose (<20%) oily components, but it is difficult for the tablet-making of high-dose (>20%) oily components. [0003] Health care products contain high-oil and ester raw materials, and the dosage forms are generally soft capsules, and a small amount is made into powder. Tablets generally require raw materials containing high oil and esters to accoun...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/04A61K47/32A61K36/00A23L33/115A23L33/10A23L29/00A23P10/28
CPCA61K9/2009A61K9/2027A61K9/2095A61K36/00A23L29/015A23L29/03A23L33/10A23L33/115A23P10/28
Inventor 黄仪友黄玲袁训贤贺瑞坤欧晓玲何健张旭光
Owner BY HEALTH CO LTD
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