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Phenanthrene compound derived from natural plants, and preparation method thereof and application thereof

A technology for natural plants and compounds, applied in the field of phenanthrene compounds and their preparation, can solve problems such as no relevant reports on the application, and achieve the effects of good antibacterial activity, good application prospect and good inhibitory activity

Active Publication Date: 2018-11-30
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the compound and its application

Method used

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  • Phenanthrene compound derived from natural plants, and preparation method thereof and application thereof
  • Phenanthrene compound derived from natural plants, and preparation method thereof and application thereof
  • Phenanthrene compound derived from natural plants, and preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A method for preparing phenanthrene compounds derived from natural plants includes the following steps:

[0046] Step (1), extract extraction: pulverize the dried whole rush to 30-50 meshes, use a 70% ethanol aqueous solution with a volume percentage concentration, extract twice at room temperature, each 6h, combine the extracts, filter, and take the filtrate to reduce Press and concentrate to get extract;

[0047] Step (2), silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, and perform gradient elution with a mixed organic solvent of petroleum ether and acetone, and each gradient eluates to the pointless TLC dot plate. , Change to the next gradient elution; collect and concentrate the gradient eluates of each gradient, monitor by TLC, and merge the same parts to obtain seven parts A1-A7;

[0048] Step (3), separation by gel chromatography: using a 1:1 volume ratio of chloroform and methanol mixed organic solvent as t...

Embodiment 2

[0050] A method for preparing phenanthrene compounds derived from natural plants includes the following steps:

[0051] Step (1), extract extraction: pulverize the dried whole rush to 30-50 meshes, use a 70% ethanol aqueous solution with a volume percentage concentration, extract twice at room temperature, each 6h, combine the extracts, filter, and take the filtrate to reduce Pressing and concentrating to obtain an extract; the ratio of the volume of the ethanol aqueous solution to the mass of the whole dry rush for each extraction is 50L: 25Kg;

[0052] Step (2), silica gel column chromatography: Dissolve the extract obtained in step (1) with a 95% methanol aqueous solution with a volume percentage of 1.5 times the weight of the extract, and then mix it with 100 mesh silica gel twice the weight of the extract After the sample is sampled, the silica gel column is loaded with 200-300 mesh. The weight of silica gel used for the column is 3 times the weight of the extract; the gradien...

Embodiment 3

[0057] A method for preparing phenanthrene compounds derived from natural plants includes the following steps:

[0058] Step (1), extract extraction: pulverize the dried whole rush to 30-50 meshes, and extract 4 times at room temperature with a volume percentage concentration of 95% ethanol aqueous solution, 10h each time, combine the extracts, filter, and take the filtrate to reduce Pressing and concentrating to obtain an extract; the ratio of the volume of the ethanol aqueous solution to the mass of the whole dry rush for each extraction is 50L: 25Kg;

[0059] Step (2), silica gel column chromatography: dissolve the extract obtained in step (1) with a 95% methanol aqueous solution with a volume percentage of 4 times the weight of the extract, and then mix it with 100 mesh silica gel with 4 times the weight of the extract After the sample, the silica gel column was loaded with a silica gel of 300 mesh, and the silica gel used for the column was 5 times the weight of the extract; t...

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Abstract

The present invention relates to a phenanthrene compound derived from natural plants, a preparation method thereof and an application thereof, and belongs to the technical field of phytochemistry. Thestructural formula of the compound is represented by the formula (I). The phenanthrene compound is firstly separated from whole herb of juncus effuses. The phenanthrene compound is determined by nuclear magnetic resonance and mass spectrometry; and the specific structure is characterized. The compound exhibits a good inhibitory activity against rhizoctonia solani, potato verticillium dahliae, sclerotinia sclerotiorun, fusahum graminearum, bipolaris carbonum, eggplant fungus phytophthora, etc.; and the minimum inhibitory concentration is 3.125-12.5 [mu]g / mL. At the same time, the compound alsoexhibits very good antibacterial activity, has a minimum inhibitory concentration of bacillus paratyphosus B at 12.5 [mu]g / mL and the minimum inhibitory concentration of micrococcus lysodeikticus at25 [mu]g / mL, and has good application prospects.

Description

Technical field [0001] The invention belongs to the technical field of phytochemistry, and specifically relates to a phenanthrene compound derived from natural plants and a preparation method and application thereof. Background technique [0002] Juncus effusus (Juncus effusus), also known as liongrass, golden cabbage or cottongrass, has a well-developed root system and high grass coverage rate and coverage, so it has a good water storage effect. Because of its low lignin content and high cellulose content, rushes are slender, tough, easy to pulp, and easy to bleach. It is a high-quality raw material for the manufacture of high-grade paper, rayon, and rayon, as well as a superior raw material for many hand-woven products. . Especially as a raw material for papermaking, its fiber content and quality are among the best in herbal fiber, better than slash pine and poplar. [0003] Phenanthrene and its derivatives have potential drug activity and have good applications in new material...

Claims

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Application Information

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IPC IPC(8): C07C43/23C07C41/34C07C41/36A01N31/16A01P1/00A01P3/00
CPCA01N31/16C07C41/34C07C41/36C07C43/23C07C2603/26
Inventor 赵伟巩效伟洪鎏李寿波张霞韩熠李廷华吴俊陈永宽
Owner CHINA TOBACCO YUNNAN IND
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