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A kind of drug susceptibility test card drying method

A drying method and drug sensitivity test technology, which is applied in the field of medicine, can solve the problems of long drying time, easy drug failure, and high drying energy consumption, so as to improve the drying rate, avoid the decomposition of easily oxidized drugs, and reduce the oxygen content.

Active Publication Date: 2020-08-11
湖南迈瑞医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the deficiencies of the above-mentioned background technology, aiming to obtain the amorphous form of a class of drugs through low-temperature and low-pressure drying, and to solve the drug sensitivity test stuck in the process of drying. The product is powder or flake solid, which is not conducive to transportation and solves the problems of high drying energy consumption and long drying time

Method used

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  • A kind of drug susceptibility test card drying method
  • A kind of drug susceptibility test card drying method
  • A kind of drug susceptibility test card drying method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] ①Preparation of working solution: prepare different concentrations and types of antibiotic solutions or biochemical working solutions required, and add non-ionic surfactant with HLB value of 3.0 to 20.0 during the preparation process;

[0041] ② Adding samples: add the prepared solution to the blank test card, and the amount added to each well is 25 μl;

[0042] ③ Pre-cooling: Put the test card that has added the sample into the partition of the drying box, close the door, cool the partition, and reduce the temperature of the product to 2-4 °C;

[0043] ④ Preliminary drying: Turn on the vacuum pump and nitrogen gas permeation switch, and set the program parameters according to the following procedures.

[0044]

[0045]

[0046] ⑤ Analyze and dry, close the nitrogen control solenoid valve, turn on the vacuum pump, and pump the vacuum to below 100Pa for 1 hour.

[0047] ⑥Packing: Vacuum-packed products in aluminum foil bags.

[0048] ⑦The entire drying time is no...

Embodiment 2

[0050] ①Preparation of working solution: prepare different concentrations and types of antibiotic solutions or biochemical working solutions required, and add non-ionic surfactant with HLB value of 3.0 to 20.0 during the preparation process;

[0051] ② Adding samples: add the prepared solution to the blank test card, and the amount added to each well is 25 μl;

[0052] ③ Pre-cooling: Put the test card that has added the sample into the partition of the drying box, close the door, cool the partition, and reduce the temperature of the product to 2-4 °C;

[0053] ④ Preliminary drying: Turn on the vacuum pump and nitrogen gas permeation switch, and set the program parameters according to the following procedures.

[0054]

[0055] ⑤ Analyze and dry, close the nitrogen control solenoid valve, turn on the vacuum pump, and pump the vacuum to below 100Pa for 1 hour.

[0056] ⑥Packing: Vacuum-packed products in aluminum foil bags.

[0057] ⑦The entire drying time is not longer tha...

Embodiment 3

[0059] ①Preparation of working solution: prepare different concentrations and types of antibiotic solutions or biochemical working solutions required, and add non-ionic surfactant with HLB value of 3.0 to 20.0 during the preparation process;

[0060] ② Adding samples: add the prepared solution to the blank test card, and the amount added to each well is 25 μl;

[0061] ③ Pre-cooling: Put the test card that has added the sample into the partition of the drying box, close the door, cool the partition, and reduce the temperature of the product to 2-4 °C;

[0062] ④ Preliminary drying: Turn on the vacuum pump and nitrogen gas permeation switch, and set the program parameters according to the following procedures.

[0063]

[0064] ⑤ Analyze and dry, close the nitrogen control solenoid valve, turn on the vacuum pump, and pump the vacuum to below 100Pa for 1 hour.

[0065] ⑥Packing: Vacuum-packed products in aluminum foil bags.

[0066] ⑦The entire drying time is not longer tha...

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Abstract

The invention discloses a method of drying a drug sensitivity test card. The method includes the steps of (1) preparing a drug and adding a sample, to be specific, adding a drug sensitivity solution in which a surfactant is added into a hole of a blank test card; (2) precooling a product to be dried; (3) drying preliminarily, to be specific, sealing a drying device of step (2), vacuumizing, charging nitrogen during vacuumizing, maintaining vacuity, heating the product, and holding the temperature; (4) resolving and drying, to be specific, reducing the vacuity to 100 pa and below, raising the temperature to 30 DEG C and above, and drying so that water content is reduced to 1% and below. The surfactant is added during the preparation of the drug herein; nitrogen is charged during drying; nosevere movement occurs in a liquid during the whole process; the problem is solved that the drug has poor stability and experiences hole skipping during drying; it is ensured that the dried drug is effectively attached in a test hole; the hole skipping problem is solved for the transporting process.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a method for drying drug sensitivity test cards. Background technique [0002] The drug susceptibility test card is a kind of in vitro diagnostic reagent used for the drug susceptibility test of microorganisms (including bacteria, fungi, and mycobacteria). The ATB series of drug susceptibility test cards of the French BioMérieux company, the TDR series of biochemical drug susceptibility test cards of Hunan Changsha Tiandiren Biotechnology Co., Ltd., etc. In order to ensure the stability of the drug in the biochemical drug susceptibility test card product during the production process and storage process and the product is convenient for transportation, the preparation of the product is generally divided into the following steps: drug weighing, drug dissolution and preparation, drug solution added to the blank test Card, dry, pack. [0003] Among them, the drying process is t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): F26B1/00F26B3/00F26B5/04
CPCF26B1/00F26B3/00F26B5/04
Inventor 何开大李昕张茂林张浩
Owner 湖南迈瑞医疗科技有限公司