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A method for enriching branched-chain fatty acids

A branched-chain fatty acid and fatty acid technology, applied in the production of fatty acids, chemical modification of fatty acids, etc., can solve the problems of unsuitability for large-scale industrial production, low purity of branched-chain fatty acids, small processing capacity, etc., and achieve mild reaction conditions and high purity. , the effect of low energy consumption

Active Publication Date: 2021-03-26
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing method for micro-separation and enrichment of branched-chain fatty acids has problems such as small processing capacity and low purity of branched-chain fatty acids, and is not suitable for large-scale industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Mix 20 grams of lanolin fatty acid, 40 grams of urea, and 200 milliliters of anhydrous methanol, reflux in a water bath at 60°C for 2 hours, cool and crystallize at 10°C for 12 hours, and filter quickly. After removing most of the solvent by rotary evaporation of the filtrate, add water to dissolve, then add petroleum ether to extract the fatty acid for 3 times, separate the liquid, wash the residual urea in the organic phase with water, add anhydrous sodium sulfate to absorb the residual water in the organic phase, 60 ℃ The solvent was removed by rotary evaporation to obtain high-purity branched-chain fatty acid with a purity of 94.17% and a recovery of branched-chain fatty acid of 38.24%.

Embodiment 2

[0026] Mix 20 grams of lanolin fatty acid, 50 grams of urea, and 50 milliliters of 80% methanol, reflux in a water bath at 60° C. for 2 hours, cool and crystallize at 20° C. for 6 hours, and quickly filter with suction. After removing most of the solvent by rotary evaporation of the filtrate, add water to dissolve, add petroleum ether to extract the fatty acid three times, separate the liquid, wash the residual urea in the organic phase with water, add anhydrous sodium sulfate to absorb the residual water in the organic phase, and rotate at 60°C Evaporate and remove the solvent to obtain high-purity branched chain fatty acid fatty acid, the purity is 91.28%, and the recovery rate of branched chain fatty acid is 21.24%.

Embodiment 3

[0028] Mix 20 grams of fish oil fatty acid, 20 grams of urea, and 100 milliliters of 90% ethanol, reflux in a water bath at 60°C for 4 hours, cool and crystallize at 10°C for 24 hours, and quickly filter with suction. After removing most of the solvent by rotary evaporation of the filtrate, add water to dissolve, extract the fatty acid three times with petroleum ether, separate the liquid, wash the residual urea in the organic phase with water, add anhydrous sodium sulfate to absorb the residual water in the organic phase, and rotate to evaporate at 60°C The high-purity branched-chain fatty acid is obtained by removing the solvent, the purity is 68.40%, and the recovery rate of the branched-chain fatty acid is 44.85%.

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Abstract

The invention discloses a branched chain fatty acid enriching method, which comprises following steps: preparing fatty acids from grease, adding a solvent and urea according to a certain ratio, carrying out refluxing under stirring, placing the mixture in a low temperature environment to cool the mixture to carry out crystallization for a certain period, performing suction filtration, subjecting the filtrate to rotary evaporation to remove the solvent, adding water to dissolve the solids, extracting branched chain fatty acids by petroleum ether, washing the organic phase by water to remove urea, adding anhydrous sodium sulfate to dry the organic phase, and finally carrying out rotary evaporation to remove the solvent to obtain high content branched chain fatty acids. Urea is used to clathrate branched chain fatty acids, the separation efficiency is high, the product recovery rate is good, long chain fatty acids that do not exist in human milk are smartly removed, and high purity branched chain fatty acids that are highly similar with human milk are obtained.

Description

technical field [0001] The invention relates to a technology for separating and purifying oil, in particular to a method for enriching branched-chain fatty acids. Background technique [0002] Branched chain fatty acid (BCFA) is a kind of fatty acid with one or more branched chains (mainly methyl) on the carbon skeleton, usually saturated fatty acid. Due to the special branched chain structure, branched chain fatty acids and their derivatives have unique physical and chemical properties, such as lower freezing point and pour point, good thermal stability and oxidation stability, and their derivatives have higher hydrolysis and dissolution stability etc. BCFA has a different digestion and metabolism pathway from straight-chain acid in the body, so that it has unique physiological regulation functions, such as anti-cancer, prevention and treatment of neonatal necrotizing colitis, prevention and treatment of ischemia and reperfusion injury, etc. [0003] Branched-chain fatty ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C11C3/00
CPCC11C3/00
Inventor 王小三陈洋金青哲王兴国韦伟
Owner JIANGNAN UNIV
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