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Tumor targeting double-drug-loading nano-carrier

A nano-carrier and tumor-targeting technology, applied in the field of biomedical engineering, can solve problems such as uncontrollable drug release, low tumor specificity, and high cytotoxicity, and achieve improved tumor targeting, low cytotoxicity, and tumor-targeted strong effect

Inactive Publication Date: 2018-12-07
YANCHENG INST OF IND TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the existing nano-drug delivery system still has problems such as low tumor specificity, high cytotoxicity, slow biodegradation, and uncontrollable drug release, which limits its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A tumor-targeting dual drug-loaded nanocarrier, including large-pore mesoporous silica, the surface of the large-pore mesoporous silica is covered with polylactic acid-glycolic acid copolymer, polylactic acid-glycolic acid copolymer is coated with polyethylene glycol After alcohol modification, a polydopamine coating is deposited and peptides are immobilized. The pore diameter of the large-aperture mesoporous silica is about 11 nm. The polypeptide is a transferrin receptor-specific polypeptide, and the transferrin receptor-specific polypeptide includes a T7 polypeptide, the mass ratio of polyethylene glycol to the polypeptide is 1:1, polylactic acid-glycolic acid The mass ratio of copolymer to polypeptide is 4:1.

Embodiment 2

[0017] A tumor-targeting dual drug-loaded nanocarrier, including large-pore mesoporous silica, the surface of the large-pore mesoporous silica is covered with polylactic acid-glycolic acid copolymer, polylactic acid-glycolic acid copolymer is coated with polyethylene glycol After alcohol modification, a polydopamine coating is deposited and a polypeptide is immobilized, and the pore diameter of the large-aperture mesoporous silica is about 14 nm. The polypeptide is specific polypeptide of transferrin receptor. The transferrin receptor-specific polypeptide includes T7 polypeptide. The mass ratio of the polyethylene glycol to the polypeptide is 5:1, and the mass ratio of the polylactic acid-glycolic acid copolymer to the polypeptide is 10:1.

Embodiment 3

[0019] A tumor-targeting dual drug-loaded nanocarrier, including large-pore mesoporous silica, the surface of the large-pore mesoporous silica is covered with polylactic acid-glycolic acid copolymer, polylactic acid-glycolic acid copolymer is coated with polyethylene glycol After alcohol modification, a polydopamine coating is deposited and peptides are immobilized. The pore diameter of the large-aperture mesoporous silica is about 12nm. The polypeptide is specific polypeptide of transferrin receptor. The transferrin receptor-specific polypeptide includes T7 polypeptide. The mass ratio of the polyethylene glycol to the polypeptide is 3:1. The mass ratio of polylactic acid-glycolic acid copolymer to polypeptide is 7:1.

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Abstract

The invention discloses a tumor targeting double-drug-loading nano-carrier. The tumor targeting double-drug-loading nano-carrier comprises large-pore-diameter mesoporous silicon dioxide, wherein the surface of the large-pore-diameter mesoporous silicon dioxide is covered with a polylactic acid-glycollic acid copolymer; and after the polylactic acid-glycollic acid copolymer is modified through polyethylene glycol, a polydopamine coating is deposited and polypeptide is fixed. The pore diameter of the large-pore-diameter mesoporous silicon dioxide is about 11 to 14nm. The tumor targeting double-drug-loading nano-carrier can be used as a tumor targeting double-drug-loading delivery system and has the advantages of good water solubility, good biocompatibility, easiness of being degraded, high drug enveloping rate, rapid degradation speed, strong tumor targeting performance, low cytotoxicity and the like.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a tumor-targeting double drug-loaded nanocarrier. Background technique [0002] According to statistics, malignant tumors are the second largest killer after cardiovascular and cerebrovascular diseases. At present, the vast majority of patients are treated by surgical resection, radiotherapy and chemical drugs. These therapies can obtain rapid and effective therapeutic effects on patients with early-stage tumors, but for patients with advanced tumors accompanied by local spread and metastasis, they have not significantly prolonged the survival period and improved the quality of life of patients, and have relatively large toxic and side effects. In recent years, studies have found that cancer is a genetic disease, which is a multi-stage long-term evolution process in which various pre-oncogenes are activated and tumor suppressor genes are inactivated in human cells under the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/04A61K47/34A61K47/10A61K47/42A61P35/00
CPCA61K9/5115A61K9/5146A61K9/5153A61K9/5169A61P35/00
Inventor 陈健朱驯
Owner YANCHENG INST OF IND TECH
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