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Biomimetic mineralization based graphene modified calcium carbonate particle, preparation method and application thereof

A graphene modification, calcium carbonate technology, applied in the direction of calcium carbonate/strontium/barium, chemical instruments and methods, cosmetic preparations, etc. properties, improved stability, heat resistance and insolubility enhancement

Active Publication Date: 2018-12-18
唯美爱科技(中国)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen from the above prior art that the composite material prepared by biomineralization with silk fibroin film as the carrier not only has good biocompatibility, but also has good adhesion and promotion effect on cells, and can also improve mechanical properties and hydrophilic properties. However, the application of biomimetic mineralization materials in the field of cosmetics is less

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) According to the mass ratio of silk protein and chitosan is 0.3:1, after mixing the silk protein solution with a molecular weight of 3800-20000 and the chitosan solution with a molecular weight of 45000-50000 evenly, add 25% of the total system The ethylene glycol solution in parts by volume was concentrated by heating and evaporating at 45° C. to obtain a concentrated silk protein / chitosan composite solution with a solid content of 7.5 wt%.

[0025] (2) Add graphene oxide solution to the solution containing calcium ions, mix evenly, add hydrazine hydrate, and heat and reduce at 80°C to obtain a graphene-modified calcium ion solution, wherein the graphene-modified calcium ion The molar ratio of graphene to calcium ions in the solution is 0.2:1.

[0026] (3) According to the ratio of the total mass of silk protein and chitosan to the total mass of graphene and calcium salt is 10:0.5, the calcium ion modified by graphene is added dropwise in the concentrated silk prot...

Embodiment 2

[0029] (1) According to the mass ratio of silk protein and chitosan is 0.6:2, after mixing the silk protein solution with a molecular weight of 1000-20000 and the chitosan solution with a molecular weight of 45000-48000 evenly, add 50% of the total system The isopropanol solution in parts by volume was concentrated by heating and evaporating at 50° C. to obtain a concentrated silk protein / chitosan composite solution with a solid content of 9 wt%.

[0030] (2) Add graphene oxide solution to the calcium ion-containing solution, mix evenly, add hydrazine hydrate, and heat and reduce at 90°C to obtain a graphene-modified calcium ion solution, wherein the graphene-modified calcium ion The molar ratio of graphene to calcium ions in the solution is 0.4:1.

[0031] (3) According to the ratio of the total mass of silk protein and chitosan to the total mass of graphene and calcium salt is 15:2, the calcium ion modified by graphene is added dropwise in the concentrated silk protein / chito...

Embodiment 3

[0034](1) According to the mass ratio of silk protein and chitosan is 0.4:1.4, after mixing the silk protein solution with a molecular weight of 5000-15000 and the chitosan solution with a molecular weight of 45000-50000 evenly, add 40% of the total system Parts by volume of the methanol solution were heated and evaporated at 48° C. to obtain a concentrated fibroin / chitosan composite solution with a solid content of 8.5 wt%.

[0035] (2) Add graphene oxide solution to the solution containing calcium ions, after mixing evenly, add hydrazine hydrate, and heat reduction at 88°C to obtain a graphene-modified calcium ion solution, wherein the graphene-modified calcium ion The molar ratio of graphene to calcium ions in the solution is 0.25:1.

[0036] (3) According to the ratio of the total mass of silk protein and chitosan to the total mass of graphene and calcium salt is 14:0.9, the calcium ion modified by graphene is added dropwise in the concentrated silk protein / chitosan compos...

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Abstract

The invention provides a biomimetic mineralization based graphene modified calcium carbonate particle, a preparation method and application thereof. The method includes the steps of: mixing a fibroinsolution with a chitosan solution evenly, then adding an alcohol solution while conducting heating evaporation concentration to obtain a concentrated fibroin / chitosan composite solution; adding a graphene oxide solution into a solution containing calcium ions, mixing the substances evenly, then adding hydrazine hydrate, and conducting heating and reduction to obtain a graphene modified calcium ionsolution; adding the graphene modified calcium ion solution dropwise into the concentrated fibroin / chitosan composite solution, conducting homogenizing stirring, and then performing spray drying treatment to obtain porous composite precursor microspheres; impregnating the porous composite precursor microspheres in a urea solution for low temperature impregnation, then taking the microspheres out,performing heating treatment, and repeating impregnation and heating treatment, thus obtaining the biomimetic mineralization based graphene modified calcium carbonate particle. The biomimetic mineralization based graphene modified calcium carbonate particle prepared according to the invention is mainly used for the field of cosmetics.

Description

technical field [0001] The invention belongs to the technical field of daily cosmetics, and in particular relates to a graphene-modified calcium carbonate particle based on imitation biomineralization and a preparation method and application thereof. Background technique [0002] Biomineralization refers to the formation of minerals, including amorphous minerals, inorganic crystals and organic crystals, through the selective precipitation of inorganic elements from the environment on specific organic matter with the participation of cells in organisms. Due to the special biological process and special biological environment, it has extremely high selectivity and directionality, so it has extremely high strength, good fracture toughness, shock absorption performance and special functions. Biomimetic mineralization is a method of synthesizing artificial crystals by simulating biomineralization. The preparation environment is a highly controllable autocatalytic process in a nea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/19A61K8/64A61K8/73A61Q19/08A61Q19/00A61Q17/00C01F11/18
CPCA61Q17/005A61Q19/00A61Q19/08A61K8/0279A61K8/19A61K8/64A61K8/736C01F11/185A61K2800/56A61K2800/10
Inventor 徐亚维
Owner 唯美爱科技(中国)有限公司