Preparation process of hematodialysis concentrate A powder

A technology of hemodialysis and preparation process, applied in the field of hemodialysis, can solve the problems of unstable product quality of hemodialysis concentrate A powder, increase in transportation and storage costs, and increase in dissolution time, and achieve easy preparation and storage, and reduce product differences. Small, stable product quality effect

Inactive Publication Date: 2018-12-28
SHANDONG WEIGAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the hemodialysis concentrate A powder in the prior art still has the following obvious defects: on the one hand, the hemodialysis concentrate A powder has higher requirements on the manufacturing process, and the hemodialysis concentrate A powder contains chlorine which is very easy to absorb moisture. Calcium chloride and magnesium chloride can easily lead to unstable product quality of hemodialysis concentrate A powder, and the quality difference between products produced by the same batch of raw materials is large; on the other hand, hemodialysis concentrate A powder needs to be processed during transportation and storage. Pay attention to moisture-proof, thus resulting in increased transportation and storage costs; and, hemodialysis concentrate A powder is easy to cause product caking due to the moisture absorption of calcium chloride and magnesium chloride, and the dissolution time of hemodialysis concentrate A powder after caking increases, And it will increase the wear and tear on the dissolution equipment

Method used

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  • Preparation process of hematodialysis concentrate A powder
  • Preparation process of hematodialysis concentrate A powder
  • Preparation process of hematodialysis concentrate A powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A hemodialysis concentrate A powder, comprising the following components by weight: 16000 g of anhydrous sodium chloride, 500 g of anhydrous potassium chloride, 600 g of calcium chloride dihydrate, 300 g of magnesium chloride hexahydrate and 600 g of anhydrous citric acid.

[0039] A preparation process of hemodialysis concentrate A powder, the operation process is completed in the operation room, and the temperature of the operation room is adjusted to 15°C, relative humidity ≤ 40%, and planktonic bacteria ≤ 100 / m 3 , sedimentation bacteria ≤ 3 / petri dish, and the pressure difference between adjacent operations ≥ 10Pa, specifically include the following steps:

[0040] (1) Take each raw material according to the above-mentioned a kind of hemodialysis concentrate A powder, and set aside;

[0041](2) Add calcium chloride and magnesium chloride to the mixing tank of the three-dimensional mixer through the feeding port after sieving, and then add anhydrous sodium chloride ...

Embodiment 2

[0047] A hemodialysis concentrate A powder, comprising the following components by weight: 22000g of anhydrous sodium chloride, 800g of anhydrous potassium chloride, 900g of calcium chloride dihydrate, 400g of magnesium chloride hexahydrate, 1000g of anhydrous citric acid and anhydrous Water glucose 7000g.

[0048] A preparation process of hemodialysis concentrate A powder, the operation process is completed in the operation room, the temperature of the operation room is adjusted to 30°C, the relative humidity is ≤40%, and the planktonic bacteria is ≤100 / m 3 , sedimentation bacteria ≤ 3 / petri dish, and the pressure difference between adjacent operations ≥ 10Pa, specifically include the following steps:

[0049] (1) Take each raw material according to the above-mentioned a kind of hemodialysis concentrate A powder, and set aside;

[0050] (2) Add calcium chloride and magnesium chloride to the mixing tank of the three-dimensional mixer through the feeding port after sieving, an...

Embodiment 3

[0056] A hemodialysis concentrate A powder, comprising the following components by weight: 21070g of anhydrous sodium chloride, 522g of anhydrous potassium chloride, 643g of calcium chloride dihydrate, 356g of magnesium chloride hexahydrate, 739g of anhydrous citric acid and anhydrous Water glucose 2000g.

[0057] A preparation process of hemodialysis concentrate A powder, the operation process is completed in the operation room, and the temperature of the operation room is adjusted to 20°C, relative humidity ≤ 40%, and planktonic bacteria ≤ 100 / m 3 , sedimentation bacteria ≤ 3 / petri dish, and the pressure difference between adjacent operations ≥ 10Pa, specifically include the following steps:

[0058] (1) Take each raw material according to the above-mentioned a kind of hemodialysis concentrate A powder, and set aside;

[0059] (2) Add calcium chloride and magnesium chloride to the mixing tank of the three-dimensional mixer through the feed port after sieving, and then add a...

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Abstract

The invention discloses hematodialysis concentrate A powder. The hematodialysis concentrate A powder is prepared from components in parts by weight as follows: 160-220 parts of sodium chloride, 5-8 parts of potassium chloride, 6-9 parts of calcium chloride, 3-4 parts of magnesium chloride, 6-10 parts of citric acid and 0-70 parts of glucose. The disclosed hematodialysis concentrate A powder is excellent in stability, not prone to caking, long in guarantee life and excellent in dissolution rate and dissolution effect. Besides, the invention also discloses a preparation process of the hematodialysis concentrate A powder. The preparation process is simple, automatic subpackaging can be realized, a large quantity of manual costs are saved, the production efficiency is improved, less waste is discharged in the production process, and the preparation process is energy-saving, environmentally friendly and favorable for popularization and use.

Description

technical field [0001] The invention relates to the technical field of hemodialysis, in particular to a preparation process of hemodialysis concentrate A powder. Background technique [0002] Hemodialysis (HD) is one of the renal replacement therapies for patients with acute and chronic renal failure. It drains the blood from the body to the outside of the body through a dialyzer composed of countless hollow fibers. The blood and the electrolyte solution (dialysate) with a similar concentration to the body are exchanged through diffusion / convection inside and outside the hollow fibers. , remove metabolic waste from the body, maintain electrolyte and acid-base balance; remove excess water from the body at the same time, and return the purified blood to the entire process called hemodialysis. Hemodialysis fluid is an important part of the hemodialysis treatment process, and the demand is very large. It is estimated that each patient needs 240L of hemodialysis fluid for 4 hour...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K9/14A61P7/08A61K31/194A61K31/7004A61K33/06
CPCA61K9/14A61K31/194A61K31/7004A61K33/06A61K33/14A61P7/08A61K2300/00
Inventor 高领杜武华林栋青邱新林刘文涛刁盈盈林艳华赵文杰
Owner SHANDONG WEIGAO PHARM CO LTD
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