Steroidal compound, preparation method and application thereof as well as antitumor drug

A steroid compound, anti-tumor technology, applied in the application field of marine microbial drugs, can solve the problem of not completely killing tumor cells, etc., achieves good application prospects, reduces production costs, and has obvious effects.

Active Publication Date: 2019-01-04
THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Steroidal compound, preparation method and application thereof as well as antitumor drug
  • Steroidal compound, preparation method and application thereof as well as antitumor drug
  • Steroidal compound, preparation method and application thereof as well as antitumor drug

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[0017] The present invention will be further described in detail below in conjunction with specific embodiments.

[0018] Preparation of steroids

[0019] (1) The granular Penicillium (available from the China Marine Microbial Species Collection and Management Center, the preservation number: MCCC 3A00475) is added to the triangular flask containing the culture medium to ferment and culture, and finally the fermentation product is obtained. The culture medium contains mannitol :20ml / L, yeast extract powder: 3g / L, KH 2 PO 4 :0.5g / L, Sodium Glutamate: 10g / L, Glucose: 10g / L, MgSO 4 ·7H 2 O: 0.3g / L, maltose: 20g / L, corn steep liquor 1mL / L. Centrifuge the fermentation product to collect the bacterial liquid and bacterial cells; add methanol to the bacterial cells for extraction, and then degrease the extract with petroleum ether and dichloromethane, and finally concentrate at low pressure to obtain the crude bacterial fermentation extract;

[0020] (2) Separate the crude bacterial fermen...

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Abstract

The invention discloses a steroidal compound. A structural formula of the steroidal compound is as shown in the description; in the structural formula of the steroidal compound, when R1 is H, R2 is H;and when R1 is OH, R2 is H or OH. The steroidal compound provided by the invention is produced by fermenting granulous penicillium in a specific medium, has antitumor activity, and can be used for preparing an antitumor drug. The invention provides a new source of compounds for researching and developing antitumor drugs, and utilizes abundant marine microorganisms as fermentation raw materials for fermentation to prepare the steroidal compound which can be used as an anti-tumor active substance, so that the cost of drug production is reduced, and the steroidal compound has a significant inhibitory effect on cancer cells, and has a good application prospect.

Description

technical field [0001] The invention belongs to the application field of marine microbial medicines, and in particular relates to steroid compounds, their preparation methods and applications, and antitumor medicines. Background technique [0002] Tumor is a huge threat to human health and life, and the key to its treatment is to find measures that can accurately curb the growth of tumor cells. The proliferation, survival and differentiation of tumor cells are affected by a variety of genetic and molecular changes. There is crossover and compensation between the various signaling pathways that tumor growth and survival depend on. This complexity makes it impossible to completely kill tumor cells by acting on only one target. This special survival mechanism of tumor cells has also resulted in the frequent emergence of resistance to existing anticancer drugs. Therefore, there is a clinical need for drugs that can act on multiple receptors or signaling pathways to affect mul...

Claims

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Application Information

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IPC IPC(8): C07J9/00C12P33/00A61K31/575A61P35/00C12R1/80
CPCA61K31/575A61P35/00C07J9/00C12P33/00
Inventor 杨献文谢春兰夏金梅李增鹏邵宗泽
Owner THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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