Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Steroidal compound, preparation method and application thereof as well as antitumor drug

A steroid compound, anti-tumor technology, applied in the application field of marine microbial drugs, can solve the problem of not completely killing tumor cells, etc., achieves good application prospects, reduces production costs, and has obvious effects.

Active Publication Date: 2019-01-04
THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This complexity makes it impossible to completely kill tumor cells by acting on only one target

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Steroidal compound, preparation method and application thereof as well as antitumor drug
  • Steroidal compound, preparation method and application thereof as well as antitumor drug
  • Steroidal compound, preparation method and application thereof as well as antitumor drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention will be further described in detail below in combination with specific embodiments.

[0018] Preparation of steroids

[0019] (1) Add Penicillium granulosa (can be purchased from China Marine Microorganism Culture Collection and Management Center, preservation number: MCCC 3A00475) into a Erlenmeyer flask containing a medium for fermentation and culture, and finally obtain a fermentation product, mannitol in the medium : 20ml / L, yeast extract powder: 3g / L, KH 2 PO 4 : 0.5g / L, sodium glutamate: 10g / L, glucose: 10g / L, MgSO 4 ·7H 2 O: 0.3g / L, maltose: 20g / L, corn steep liquor 1mL / L. Centrifuge the fermentation product to collect the bacterial liquid and bacterial cells; add methanol to the bacterial cells for extraction, degrease the extract with petroleum ether and dichloromethane, and finally concentrate under low pressure to obtain the crude cell fermentation extract;

[0020] (2) Separating the crude extract from cell fermentation in step (1)...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a steroidal compound. A structural formula of the steroidal compound is as shown in the description; in the structural formula of the steroidal compound, when R1 is H, R2 is H;and when R1 is OH, R2 is H or OH. The steroidal compound provided by the invention is produced by fermenting granulous penicillium in a specific medium, has antitumor activity, and can be used for preparing an antitumor drug. The invention provides a new source of compounds for researching and developing antitumor drugs, and utilizes abundant marine microorganisms as fermentation raw materials for fermentation to prepare the steroidal compound which can be used as an anti-tumor active substance, so that the cost of drug production is reduced, and the steroidal compound has a significant inhibitory effect on cancer cells, and has a good application prospect.

Description

technical field [0001] The invention belongs to the application field of marine microbial medicines, and in particular relates to steroid compounds, their preparation methods and applications, and antitumor medicines. Background technique [0002] Tumor is a huge threat to human health and life, and the key to its treatment is to find measures that can accurately curb the growth of tumor cells. The proliferation, survival and differentiation of tumor cells are affected by a variety of genetic and molecular changes. There is crossover and compensation between the various signaling pathways that tumor growth and survival depend on. This complexity makes it impossible to completely kill tumor cells by acting on only one target. This special survival mechanism of tumor cells has also resulted in the frequent emergence of resistance to existing anticancer drugs. Therefore, there is a clinical need for drugs that can act on multiple receptors or signaling pathways to affect mul...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07J9/00C12P33/00A61K31/575A61P35/00C12R1/80
CPCA61K31/575A61P35/00C07J9/00C12P33/00
Inventor 杨献文谢春兰夏金梅李增鹏邵宗泽
Owner THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com