Steroidal compound, preparation method and application thereof as well as antitumor drug
A steroid compound, anti-tumor technology, applied in the application field of marine microbial drugs, can solve the problem of not completely killing tumor cells, etc., achieves good application prospects, reduces production costs, and has obvious effects.
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[0017] The present invention will be further described in detail below in conjunction with specific embodiments.
[0018] Preparation of steroids
[0019] (1) The granular Penicillium (available from the China Marine Microbial Species Collection and Management Center, the preservation number: MCCC 3A00475) is added to the triangular flask containing the culture medium to ferment and culture, and finally the fermentation product is obtained. The culture medium contains mannitol :20ml / L, yeast extract powder: 3g / L, KH 2 PO 4 :0.5g / L, Sodium Glutamate: 10g / L, Glucose: 10g / L, MgSO 4 ·7H 2 O: 0.3g / L, maltose: 20g / L, corn steep liquor 1mL / L. Centrifuge the fermentation product to collect the bacterial liquid and bacterial cells; add methanol to the bacterial cells for extraction, and then degrease the extract with petroleum ether and dichloromethane, and finally concentrate at low pressure to obtain the crude bacterial fermentation extract;
[0020] (2) Separate the crude bacterial fermen...
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