Personalized calcium phosphate biomimetic bone tissue scaffold and its preparation method and application

A calcium phosphate biomimetic bone and tissue scaffold technology, applied in tissue regeneration, prosthesis, medical science and other directions, can solve the problem of incomplete osteogenesis of nutrients, and achieve bone repair, improve mechanical properties, and complete osteogenesis. Effect

Active Publication Date: 2021-08-31
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned technical problems in the related art, the present invention provides a personalized calcium phosphate biomimetic bone tissue scaffold and its preparation method and application. The peripheral structure of the cloth, the peripheral structure includes lamellar sheets arranged in sequence, and there are gaps between the lamellar sheets, which solves the problem of bone formation caused by the difficulty in transporting nutrients from the outside to the inside in the past in the dense external and internal porous structures. incomplete question

Method used

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  • Personalized calcium phosphate biomimetic bone tissue scaffold and its preparation method and application
  • Personalized calcium phosphate biomimetic bone tissue scaffold and its preparation method and application
  • Personalized calcium phosphate biomimetic bone tissue scaffold and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] 1. Configure BCP (HA: β-TCP is 3:7) slurry with a volume fraction of 15%:

[0075] Weigh 15g of nanoscale BCP (particle size of 1000nm), 35g of nanoscale β-TCP (particle size of 5000nm), and 0.5g of MgO into a ball mill jar, ball mill at a speed of 30r / min for 24h, and sieve to obtain 50g of biphasic Calcium phosphate powder is ready for use; put 50g of biphasic calcium phosphate powder in a ball mill jar, add 1ml of 40% vt ammonium polyacrylate, 5ml of 10% vt polyvinyl alcohol, and 91ml of deionized water and mix thoroughly with 30r / min ball mill for 24h to obtain the volume For the BCP slurry with a fraction of 15%, the biphasic calcium phosphate powder accounts for 15% vt of the slurry, the dispersant accounts for 0.9% vt, and the binder accounts for 4% vt.

[0076] 2. Slurry freezing and drying:

[0077] Inject the ball-milled slurry into a personalized mold, set the temperature of the cold source to -15°C, control the ambient temperature to 1-4°C, and freeze for 2...

Embodiment 2

[0082] 1. Configure BCP (HA: β-TCP is 2:8) slurry with a volume fraction of 20%:

[0083] Weigh 10g of nanoscale BCP (particle size of 1000nm), 40g of nanoscale β-TCP (particle size of 5000nm), and 0.5g of MgO into a ball mill jar, ball mill for 24 hours at a speed of 30r / min, and sieve to obtain 50g of biphasic Calcium phosphate powder is ready for use; put 50g of biphasic calcium phosphate powder in a ball mill tank, add 61.3ml of deionized water, 1ml of 40% vt ammonium polyacrylate, 2.5ml of 10% vt polyvinyl alcohol and mix thoroughly by ball milling at 30r / min for 24h. A BCP slurry with a volume fraction of 20% was obtained, wherein the biphasic calcium phosphate powder accounted for 30% vt of the slurry, the dispersant accounted for 1.2% vt, and the binder accounted for 3% vt.

[0084] 2. Slurry freezing and drying

[0085] Inject the ball-milled slurry into a personalized mold, set the temperature of the cold source to -20°C, control the ambient temperature to 1-4°C, an...

Embodiment 3

[0089] 1. Configure BCP (HA: β-TCP is 4:6) slurry with a volume fraction of 25%:

[0090] Weigh 20g nanoscale BCP (particle size is 5000nm), 30g nanoscale β-TCP (particle size is 1000nm), 0.5gMgO, put them into a ball mill jar, ball mill at a speed of 30r / min for 12h, and sieve to obtain 50g biphasic Calcium phosphate powder is ready for use; put 50g of biphasic calcium phosphate powder in a ball mill tank, add 48ml of deionized water, 0.8ml of 40% vt ammonium polyacrylate, 3.5ml of 10% vt polyvinyl alcohol and mix thoroughly by ball milling at 30r / min for 24h. A BCP slurry with a mass fraction of 25% was obtained, wherein the biphasic calcium phosphate powder accounted for 25% vt of the slurry, the dispersant accounted for 1.2% vt, and the binder accounted for 5.4% vt.

[0091] 2. Slurry freezing and drying

[0092] Inject the ball-milled slurry into a personalized mold, set the temperature of the cold source to -25°C, control the ambient temperature at 1-4°C, and freeze for...

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Abstract

The present invention provides a personalized calcium phosphate bionic bone tissue scaffold and its preparation method and application. The personalized calcium phosphate bionic bone tissue scaffold includes a central channel layer and a peripheral structure arranged radially around the central channel layer. The peripheral structure includes There are gaps between the ply sheets arranged sequentially in layers; the gap ratio is 65-70%, and the gaps are in the form of laminations. The structure of the personalized calcium phosphate biomimetic bone tissue scaffold solves the problem of incomplete osteogenesis caused by the difficulty in transporting nutrients from the outside to the inside in the dense external and internal porous structure. It can ensure that cells and new blood vessels grow deep inside the scaffold, making The bone formation is more complete; the large hole in the center of the scaffold can penetrate into the degradable polymer material, which can improve the mechanical properties of the scaffold as a whole; the shape-matching bone repair scaffold is made through a personalized mold, so that the scaffold has more structure and function. big advantage.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a personalized calcium phosphate bionic bone tissue scaffold and its preparation method and application. Background technique [0002] Scaffold materials for bone repair should have good plasticity, biocompatibility, osteoconductivity, bioactivity, and degradability, as well as high porosity, interconnected porous structure, and sufficient mechanical strength. However, the existing bone repair materials, such as metal implant materials such as titanium and titanium alloys, stainless steel, and cobalt-chromium alloys, can be individually designed according to the shape of bone defects and have good mechanical strength, but they lack biological activity and do not degrade. ; Calcium phosphate ceramics have biological activity and can be degraded in vivo, but their mechanical strength is low; polymer materials can be degraded in vivo, but their mechanical strength is lo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/42A61L27/56A61L27/58C04B35/447C04B35/622C04B35/626C04B35/64
CPCA61L27/425A61L27/56A61L27/58A61L2430/02C04B35/447C04B35/622C04B35/62605C04B35/64C04B2235/6562C04B2235/6567C04B2235/661
Inventor 陈良建陈代远
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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