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A kind of preparation method of nano-hydroxyapatite-chitosan artificial bone

A technology of nano-hydroxyapatite and chitosan, which is applied in pharmaceutical formulations, prostheses, and drug delivery, can solve problems such as processing difficulties and restrictions on popularization and application, and achieve simple preparation processes, controllable process parameters, and high dispersibility Improved effect

Active Publication Date: 2021-06-01
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, due to the strong hydrogen bond associations in and between chitosan molecules, chitosan has a compact crystalline structure, does not melt, and is also insoluble in common organic solvents, resulting in processing difficulties and limiting its popularization and application.

Method used

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  • A kind of preparation method of nano-hydroxyapatite-chitosan artificial bone
  • A kind of preparation method of nano-hydroxyapatite-chitosan artificial bone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 nanometer hydroxyapatite-chitosan artificial bone

[0033] 1. Preparation of surface-modified nano-hydroxyapatite. Take polyethylene glycol 600, configure it into a 5% aqueous solution, and add nano-hydroxyapatite under stirring. After the addition, keep stirring at 55°C for 6 hours, then ultrasonically disperse for 3 hours, filter, and the filter cake is washed with absolute ethanol in turn. 1. After washing with chloroform, dry the organic solvent, vacuum-dry at 100° C. for 24 hours, and grind to obtain surface-modified nano-hydroxyapatite.

[0034] 2. Preparation of butyrylated chitosan. Take chitosan powder, add methanesulfonic acid in an ice-water bath, stir to make chitosan fully swell, slowly add butyric anhydride dropwise under continuous stirring, react at room temperature for 8 hours, overnight at -20°C, take out, filter, double steam Suspended in water, adjusted to pH 7 with ammonia water, boiled for 2 hours, filtered while h...

Embodiment 2

[0037] The preparation of embodiment 2 nanometer hydroxyapatite-chitosan artificial bone

[0038] 1. Preparation of surface-modified nano-hydroxyapatite. Take polyethylene glycol 800, configure it into a 5% aqueous solution, and add nano-hydroxyapatite under stirring. After the addition, keep stirring at 60°C for 6 hours, then ultrasonically disperse for 3.5 hours, filter, and the filter cake is washed with absolute ethanol in turn. 1. After washing with chloroform, dry the organic solvent, vacuum-dry at 90° C. for 24 hours, and grind to obtain surface-modified nano-hydroxyapatite.

[0039] 2. Preparation of butyrylated chitosan. Take chitosan powder, add methanesulfonic acid in an ice-water bath, stir to make chitosan fully swell, slowly add butyric anhydride dropwise under continuous stirring, react at room temperature for 8 hours, overnight at -20°C, take out, filter, double steam Suspended in water, adjusted to pH 7 with ammonia water, boiled for 2 hours, filtered while ...

Embodiment 3

[0042] The preparation of embodiment 3 nanometer hydroxyapatite-chitosan artificial bone

[0043] 1. Preparation of surface-modified nano-hydroxyapatite. Take polyethylene glycol 1000, configure it into a 10% aqueous solution, add nano-hydroxyapatite under stirring, after the addition, keep stirring at 80°C for 10 hours, then ultrasonically disperse for 3 hours, filter, and filter the cake in turn with absolute ethanol 1. After washing with chloroform, dry the organic solvent, vacuum-dry at 140° C. for 40 hours, and grind to obtain surface-modified nano-hydroxyapatite.

[0044] 2. Preparation of butyrylated chitosan. Take chitosan powder, add methanesulfonic acid in an ice-water bath, stir to make chitosan fully swell, slowly add butyric anhydride dropwise under continuous stirring, react at room temperature for 8 hours, overnight at -20°C, take out, filter, double steam Suspended in water, adjusted to pH 7 with ammonia water, boiled for 2 hours, filtered while hot, washed wit...

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Abstract

The invention discloses a method for preparing nano-hydroxyapatite-chitosan artificial bone. Specifically, the invention uses surface-modified nano-hydroxyapatite and chitosan as raw materials, and mixes, extrudes, granulates, Preparation of artificial bone by injection molding, through the surface modification of nano-hydroxyapatite, the dispersion of nano-hydroxyapatite is improved, and its binding ability with chitosan is improved, so that the final artificial bone has better mechanical properties properties and hydrophilicity.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a preparation method of nano-hydroxyapatite-chitosan artificial bone. Background technique [0002] The research on biomedical materials is an emerging interdisciplinary subject developed in recent decades. With the development of global aging trend and frequent occurrence of bone trauma, bone repair and bone replacement materials have gradually become the focus of this field. With the gradual improvement of people's requirements for material performance, a single type of biomaterial is difficult to meet the clinical requirements. Therefore, the use of materials with different properties for composite biomaterials to obtain composite biomaterials with excellent clinical performance is a current research hotspot. [0003] With the continuous deepening of research, the research on nano-hydroxyapatite / chitosan composite materials has made great progress. Practice has proved that...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/50
CPCA61L27/46A61L27/50A61L2400/12A61L2430/02C08L5/08
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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