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A lyotropic liquid crystal drug carrier and a preparation method and application thereof

A technology of lyotropic liquid crystal and ethyl oleate, which is used in drug combinations, pharmaceutical formulations, antipyretics and other directions to achieve the effects of improving drug release properties, improving drug solubility and stability, and good sustained release effect.

Active Publication Date: 2019-01-11
海生健康科技(青岛)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The lyotropic liquid crystal carrier with above-mentioned reagent as raw material has not yet been reported

Method used

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  • A lyotropic liquid crystal drug carrier and a preparation method and application thereof
  • A lyotropic liquid crystal drug carrier and a preparation method and application thereof
  • A lyotropic liquid crystal drug carrier and a preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0053] 1. Drawing of phase diagram

[0054] First, according to the molar ratio of 4 / 1, accurately weigh the surfactant and place it in a colorimetric tube, and mix well; secondly, according to the change of the ratio of the surfactant to the oil phase from 10:0 to 0:10, accurately weigh the oleic acid in sequence Ethyl ester in different colorimetric tubes, stir and mix well; finally, add double distilled water drop by drop to the colorimetric tubes, the percentage of water increases at intervals of 2%, use magnetic stirring in a water bath at 40-50°C Stir evenly with a mixer, then place in a water bath at 25°C to balance, observe and record the changes in the phase state and appearance of the aggregates, and it is necessary to extend the equilibrium time of the aggregates when approaching the phase boundary. The phase boundary is preliminarily judged by visually observing the color, transparency, hardness, viscosity, etc. of the aggregates.

[0055] 2. Preparation of sample...

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Abstract

The invention belongs to the field of pharmaceutical preparations, in particular to a lyotropic liquid crystal drug carrier and a preparation method and application thereof. Twain-80, soybean lecithin, ethyl oleate and water in a certain proportion can obtain lyotropic liquid crystal phase, further adjusting that proportion of reagent, and confirm that hexagonal phase lyotropic liquid crystal andlamellar phase lyotropic liquid crystal are also prepared by polarizing texture measurement. It is found that the hexagonal and layered phases have good shear viscosity, which means that the crystalline phase has good stability and can be used as drug carrier. Curcumin is encapsulated in hexagonal phase and drug release is investigated. The results showed that hexagonal phase had good sustained-release effect and the release curve of layered phase fitted the first-order kinetic equation well. The suitable release dosage form could be selected according to the clinical application.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a lamellar phase and hexagonal phase lyotropic liquid crystal carrier composed of Tween-80 / soybean lecithin / ethyl oleate / water system. Background technique [0002] Curcumin is a herbal polyphenolic compound extracted from turmeric, which has various pharmacological activities: anti-oxidation, anti-inflammatory, anti-cancer, etc. It is a good polyphenolic drug. However, it is unstable under conditions such as light, heat and alkalinity, and its solubility in water is low, which limits the application of curcumin. Generally, the utilization rate of the drug is improved by modifying or constructing the drug carrier. After the drug is modified, some active groups will be destroyed, reducing the activity of the drug, and the operation process is generally more complicated. Constructing a drug carrier and encapsulating the drug avoids this situation. This method...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/24A61K47/22A61K47/12A61K31/12A61P39/06A61P29/00A61P35/00
CPCA61K9/1274A61K31/12A61K47/12A61K47/22A61K47/24A61P29/00A61P35/00A61P39/06
Inventor 王仲妮周玉芳张恒戚平岳莹
Owner 海生健康科技(青岛)有限公司
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