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Orally disintegrating tablet

A technology of oral disintegration and polyethylene glycol, which is applied in the field of medicine, can solve the problems of liver first-pass effect, inconvenient medication, poor mechanical strength, etc., and achieve the effect of simple acquisition method, low cost and good mechanical strength

Inactive Publication Date: 2019-01-11
JIANGXI JINSHUIBAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main dosage forms that use Paecilomyces hepaticus Cs-4 bacteria powder as the main drug are Jinshuibao Capsules and Jinshuibao Tablets, but the existing dosage forms need to be taken with water or other liquids, which is inconvenient to use and has a liver first-pass effect
Orally disintegrating tablets can avoid the liver first-pass effect, but the existing orally disintegrating tablets all have a contradiction between disintegration time and mechanical strength, that is, those with short disintegration time often have low hardness and poor mechanical strength, and are easy to transport during transportation. Damage; and good mechanical strength cannot disintegrate in the oral cavity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] Wherein, the ethanolate of corn starch slurry is prepared by the following method: take 1-1.5 parts by weight of corn starch, add 1-2 parts by weight of water at a temperature of 45°C, stir at a speed of 100-120r / min for 15-30min, and then Add 1-3 parts by weight of boiling water, heat in a water bath at 80°C, and continue stirring for 25-35 minutes to obtain cornstarch slurry, then add 12-20 parts by weight of ethanol with a mass concentration of 75%, and stir for 30-40 minutes to obtain .

[0031] The suspending agent is selected from one or both of gum arabic, gelatin, tragacanth gum, peach gum, sodium alginate and sodium carboxymethylcellulose, preferably gum arabic. The flavoring agent is selected from one of sucrose, stevioside, sorbitol, aspartame and sweet orange essence, preferably sucrose.

[0032] The aforementioned orally disintegrating Jinshuibao tablets are prepared by the following steps:

[0033] S1. Take the Cs-4 Cordyceps fungus powder and grind it i...

Embodiment 1

[0041] An orally disintegrating Jinshuibao tablet is prepared from the following raw and auxiliary materials in parts by weight: 10 parts of Cs-4 cordyceps fungus powder, 20 parts of ethanolate of corn starch slurry, 200015 parts of polyethylene glycol, 2 parts of gelatin, stevia glycosides 1.5 parts. Among them, the ethanolate of corn starch slurry is prepared by the following method: take 1 weight part of corn starch, add 1 weight part of water at a temperature of 45°C, stir at a speed of 100r / min for 15min, then add 1 weight part of boiling water, place in Heat in a water bath at 80° C., continue to stir for 25 minutes to obtain corn starch slurry, then add 12 parts by weight of ethanol with a mass concentration of 75%, and stir for 30 minutes to obtain the product.

[0042] Its preparation method is as follows:

[0043] S1. Take the Cs-4 Cordyceps fungus powder and pulverize it into a fine powder with a universal grinder, weigh 10 parts by weight of the fine powder, and s...

Embodiment 2

[0048] An orally disintegrating Jinshuibao tablet is prepared from the following raw and auxiliary materials in parts by weight: 12 parts of Cs-4 Cordyceps fungus powder, 30 parts of ethanolate of corn starch slurry, 200020 parts of polyethylene glycol, 5 parts of gum arabic, 3 parts sucrose. Among them, the ethanolate of corn starch slurry is prepared by the following method: take 1.2 parts by weight of corn starch, add 1.5 parts by weight of water at a temperature of 45°C, stir at a speed of 110r / min for 20min, then add 2 parts by weight of boiling water, place in Heat in a water bath at 80° C., continue stirring for 30 minutes to obtain corn starch slurry, then add 15 parts by weight of ethanol with a mass concentration of 75%, and stir for 35 minutes to obtain the product.

[0049] Its preparation method is as follows:

[0050] S1. Take the Cs-4 Cordyceps fungus powder and pulverize it into a fine powder with a universal grinder, weigh 12 parts by weight of the fine powde...

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Abstract

The invention belongs to the technical field of medicine, and provides an orally disintegrating Jinshuibao tablet, which is prepared from the following raw and auxiliary materials in parts by weight:Cs-4 Cordyceps sinensis powder 10-15 parts, ethanolate of corn starch slurry 20-40 parts, polyethylene glycol 15-30 parts, suspending agent 2-8 parts, and corrigent 1.5-5.5 parts. The preparation method comprises the following steps of: grinding Cs-4 pulverize Cordyceps sinensis powder into fine powder for later use; mixing ethanolate of corn starch slurry and polyethylene glycol of the prescription amounts, adding fine powder step by step to prepare drug dispersion powder; taking the prescription amount of suspending agent and adding water to make a 0.3-0.6% aqueous solution, step by step adding the drug dispersion powder, then adding the prescription amount of flavoring agent, and stirring to obtain mixed medicinal liquid; distributing the edicinal liquid into medicine containers, freezemolding and drying to obtain a product. The Jinshuibao tablet prepared by the invention has moderate hardness, fast oral disintegration, quick onset of effect, good curative effect and good taste; there is no need to take the tablet with water, and the tablet is convenient to take.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to an orally disintegrating Jinshuibao tablet. Background technique [0002] Paecilomyces hepiali Cs-4 powder is a Cordyceps fungus isolated from fresh cordyceps sinensis (Berk) sacc --- Paecilomyces hepiali Chen&Dai, cultured by submerged fermentation, filtered, Dried and crushed products. [0003] The strain of Paecilomyces bat moth was isolated and purified from natural Cordyceps sinensis produced in Qinghai by Jiangxi Sinopharm Co., Ltd. and the Key Laboratory of Natural Drug Biosynthesis, Ministry of Health, Institute of Materia Medica, Chinese Academy of Medical Sciences. Bacteria powder has been approved by the Ministry of Health as a new class of raw material drug since 1989 (document number: (89) Weiyao Zhunzi No. Z-17). In more than ten years of clinical application, its good clinical effect and reliable safety It is deeply recognized by domestic and foreign medical ex...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61K9/20A61K47/36A61P11/00
CPCA61K9/0056A61K9/2059A61K36/068A61P11/00
Inventor 彭常春邹武斌李义保何平清
Owner JIANGXI JINSHUIBAO PHARM CO LTD