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A preparation method of extract of Daphniphyllum calycinum and Polygonum hydropiper L.

A technology for the extract of Aurantia cerevisiae and its extract, which is applied in the field of preparation of the extracts of Aurantia ceratus and Polygonum punctatus, can solve the problems affecting the product quality of pharmaceutical compositions, low content of active ingredients, unfavorable industrial production, etc., and achieve good operability and preparation The effect of good stability and easy handling

Inactive Publication Date: 2019-01-15
HAINAN HUALON PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existence of the above-mentioned impurities causes the problems of high paste yield and low content of active ingredients in the extraction of the maple and Polygonum japonica. These impurities not only have no effect, but also affect the product quality of the pharmaceutical composition prepared from the extract.
[0005] Chinese patent 200510071092.3 discloses a method of decocting and extracting the maple and Polygonum japonica, followed by purification by column chromatography. Although this method can improve the purity of the extract to a certain extent, a large amount of ethanol is required in the process. High cost, not conducive to industrial production

Method used

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  • A preparation method of extract of Daphniphyllum calycinum and Polygonum hydropiper L.
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  • A preparation method of extract of Daphniphyllum calycinum and Polygonum hydropiper L.

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Embodiment 1

[0040] A method for preparing the extract of maple aurantiaceae and Polygonum punctatus, the method comprises the steps of:

[0041] 1) Take 4000g of maple and 2000g of Polygonum caperica, add 8 times of water to decoct for 1.5 hours for the first time, add 6 times of water for the second time and decoct for 1 hour, and combine the decoction;

[0042]2) Take the above decoction, filter it with a ceramic membrane with a pore size of 30nm, the filtration pressure is 0.30MPa, the filtration temperature is 65°C, and the membrane flux is 145L / m 2 .h, filtrate standby;

[0043] 3) The above filtrate is concentrated under reduced pressure to a thick paste with a relative density of 1.30-1.35 (60°C), dried below 80°C, and crushed into fine powder.

Embodiment 2

[0045] A method for preparing the extract of maple eucalyptus and Polygonum punctatus, the method comprises the steps of:

[0046] 1) Take 3000g of maple and 3000g of Polygonum japonica, add 6 times of water for the first time and decoct for 2.5 hours, add 4 times of water for the second time and decoct for 1.5 hours, add 4 times of water for the third time and decoct for 0.5 hours, and combine the decoction ;

[0047] 2) Take the above decoction, filter it with a cellulose ester membrane with a pore size of 200nm, the filtration pressure is 0.40MPa, the filtration temperature is 90°C, and the membrane flux is 50L / m 2 .h, filtrate standby;

[0048] 3) The above filtrate is concentrated under reduced pressure to a thick paste with a relative density of 1.30-1.35 (60°C), dried below 80°C, and crushed into fine powder.

Embodiment 3

[0050] A method for preparing the extract of maple eucalyptus and Polygonum punctatus, the method comprises the steps of:

[0051] 1) Take 4000g of maple and 2000g of Polygonum caperica, add 8 times of water to decoct for 1.5 hours for the first time, add 6 times of water to decoct for 1 hour for the second time, and combine the decoction;

[0052] 2) Take the above decoction, use a tubular membrane ultrafiltration with a molecular weight cut-off of 100,000 Daltons, the filtration pressure is 0.30MPa, the filtration temperature is 35°C, and the membrane flux is 195L / m 2 .h, filtrate standby;

[0053] 3) The above filtrate is concentrated under reduced pressure to a thick paste with a relative density of 1.30-1.35 (60°C), dried below 80°C, and crushed into fine powder.

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Abstract

The invention discloses a preparation method of the extract of Daphniphyllum calycinum and Polygonum hydropiper L., which comprises the following steps: 1) taking the mixture of Daphniphyllum calycinum and Polygonum hydropiper L., decocting with water to obtain decoction; 2) purifying the decoction obtained in the step 1) by means of microfiltration and / or ultrafiltration at a filtration pressureof 0.20-0.40 MPa at 30-90 DEG C, with membrane flux being 50-400L / m<2>.h, wherein, the membrane used for the microfiltration is one of cellulose ester membrane, polypropylene membrane, metal membrane,ceramic membrane and glass membrane, and the pore diameter is 30-200 nm; the membrane used for the ultrafiltration is one of polyethersulfone membrane, tubular membrane, magnetic composite membrane,polysulfone, polyethersulfone, cellulose acetate, polyamide and polytetrafluoroethylene, and the molecular weight cut-off is 10,000-100,000 dalton; 3) concentrating that filtrate into thick paste, drying, and pulverizing into fine powder. The active ingredient enrichment effect of the method is good, and the purity of the obtained extract is high. When the extract is used for prepare a pharmaceutical composition for treating acute and chronic gastroenteritis, the obtained pharmaceutical composition has good stability.

Description

technical field [0001] The invention relates to a preparation method of an extract of traditional Chinese medicine, in particular to a preparation method of extracts of maple japonica and Polygonum punctatus. Background technique [0002] The original prescription for the combined use of Niu Erfeng and Polygonum punctatus comes from folk prescriptions in Qionghai County, Hainan Province. Modern medical research has found that the compatibility of the two can harmonize the intestines and stomach, restore normal ascending and descending, and restore the physiological functions of the gastrointestinal tract. The combination of the two For many years, it has been clinically used to treat acute gastroenteritis caused by unhealthy middle movement, qi stagnation and dampness, and the resulting indigestion such as abdominal distension, abdominal pain and diarrhea. In this prescription, Niuerfeng is the king drug, and its main active ingredients are flavonoids and alkaloids, among wh...

Claims

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Application Information

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IPC IPC(8): A61K36/70A61P1/14A61P1/12A61P29/00A61P1/00A61P1/04
CPCA61K36/185A61K36/70A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 翟小玲黄国豪杨丹丹蔡颖红
Owner HAINAN HUALON PHARM
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