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Biodegradable film, preparation method and application thereof

A biodegradable film and film-forming technology, which is applied in medical science, surgery, anticoagulation treatment, etc., can solve the problems of increasing production and product costs, conflicting between mechanical strength and in vivo degradation time, and not being able to meet the needs of drug loading.

Pending Publication Date: 2019-01-15
孙雨龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with solid-state membranes, although this incompletely coupled fluid material is more suitable for coating on the surgical site during clinical operations, it needs to be prepared temporarily before use. Whether it is the timing of the reaction or clinical use, the requirements for the operator are high. , the operation technology will affect the properties and isolation effect of the isolation film, such as the adhesion and strength of the film, and the adjustment of raw materials and concentration will also conflict with the mechanical strength of the final film and the degradation time in vivo. On the other hand, this Fluid materials cannot well meet the drug loading requirements
[0008] On the other hand, the hemostatic and anti-adhesion materials currently used for tissue wounds, whether they are powders, sponges or films, in the preparation process, additives such as cross-linking agents, foaming agents, and plasticizers are indispensable. The potential risks introduced by the use of additives need to remove excess additives after the reaction is completed. In order to separate these small molecules from the formed polymer membrane, dialysis treatment is usually required, which increases the cost of preparation and products

Method used

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  • Biodegradable film, preparation method and application thereof
  • Biodegradable film, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Dissolve 100 mg of gelatin in 10 ml of deionized water at 50 °C, pour it into a square horizontal tank made of polytetrafluoroethylene with a bottom size of 5 cm x 8 cm, place it horizontally at room temperature to solidify, dry naturally, wash with distilled water if necessary, and dry in the air Finally, carefully peel the gelatin film from the polytetrafluoroethylene tank, the mass per unit area of ​​the film is about 2.5mg / cm 2 .

Embodiment 2

[0040] Dissolve 100 mg of gelatin and 10 mg of sodium hyaluronate in 10 ml of deionized water at 50°C, pour it into a square horizontal tank made of polytetrafluoroethylene 5 cm x 8 cm, place it horizontally at room temperature to solidify, dry naturally, and use as needed Wash with distilled water, and carefully peel off the membrane from the PTFE tank after drying. The mass per unit area of ​​the membrane is about 2.75mg / cm 2 .

Embodiment 3

[0042] Dissolve 100 mg of gelatin and 10 mg of sodium carboxymethyl cellulose in 10 ml of deionized water at 50°C, pour it into a square horizontal tank made of polytetrafluoroethylene 5 cm x 8 cm, place it horizontally at room temperature, dry it naturally, and use as needed Wash with distilled water, and carefully peel off the membrane from the PTFE tank after drying. The mass per unit area of ​​the membrane is about 2.75mg / cm 2 .

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Abstract

The invention provides a biodegradable film, a preparation method and application thereof. The preparation method of the biodegradable film includes: placing a mobile phase prepared form film-formingraw materials in a dry flat bottom container, conducting solidification into a film with a mass of 0.1-15mg / cm<2>. The film-forming raw materials include biocompatible macromolecular materials containing hydroxyl, amino and / or carboxyl. The biodegradable film provided by the invention can achieve effective attachment to tissue directly, also has the advantages of good mechanical properties, easy bending and good drug loading effect, can effectively prevent tissue leakage and adhesion at abdomen, heart and blood vessels, spine, tendon, gynecological pelvic cavity and other parts, and also can be used as a drug carrier for medical treatment.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and relates to a biodegradable film and its preparation method and application. The biodegradable film can be closely attached to tissues, and is used to prevent tissue leakage, tissue adhesion after surgery and as a carrier The drug is released locally in the tissue. Background technique [0002] During the healing process after tissue injury and surgery, interstitial adhesions often occur in patients' wounds, especially in the abdomen, spine, and flexor tendons. According to statistics, after ordinary abdominal surgery, the incidence of abdominal adhesions is between 67% and 93%, and after open gynecological pelvic surgery, the incidence of adhesions is as high as 97%. Abdominal surgical adhesions can lead to serious clinical complications, such as intestinal obstruction, abdominal and pelvic pain, infertility, etc., increasing the difficulty of reoperation and the potential risk ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L89/00C08L1/28C08L5/08C08L5/04
CPCC08J5/18C08L5/08C08L89/00C08J2305/08C08J2389/00C08J2401/28C08J2405/04C08L2201/06C08L2203/16C08L1/286C08L1/284C08L5/04A61L31/16A61L33/06A61L33/08C08L1/02C08L1/28C08L3/02C08L5/00
Inventor 孙雨龙
Owner 孙雨龙
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