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DNA sensor and detection method based on graphene Hall effect

A detection method and sensor technology, applied in instruments, measuring devices, scientific instruments, etc., can solve problems such as detection sensitivity and detection limit restrictions

Inactive Publication Date: 2019-01-15
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the devices that use transistors to detect DNA are limited by the detection sensitivity and detection limit due to the influence of the Debye length of the solution.

Method used

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  • DNA sensor and detection method based on graphene Hall effect
  • DNA sensor and detection method based on graphene Hall effect
  • DNA sensor and detection method based on graphene Hall effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Example 1 The establishment of the standard curve of DNA sensor 1 and DNA detection based on graphene Hall effect

[0098] 1) Growth of graphene film by chemical vapor deposition

[0099] Clean the 25μm thick copper foil with acetone and alcohol respectively to remove surface impurities, dry it with nitrogen, put it into a tube furnace and heat it up to 1050°C, and keep it at this temperature for 30 minutes. The whole process is in a hydrogen protective atmosphere. Then feed methane, the ratio of hydrogen to methane is 1:1. Grow graphene under these conditions for 30 minutes, turn off the gas after the end, and cool down to room temperature.

[0100] (2) Wet transfer of gold film protection

[0101] A 70nm-thick gold film was deposited on the surface of the graphene-grown copper foil as a protective layer, and then placed in a 0.1M ammonium persulfate solution to etch the copper foil completely, and then cleaned with deionized water after etching The gold / graphene fi...

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Abstract

The invention relates to a DNA sensor and detection method based on graphene Hall effect. Specifically, the invention discloses a DNA sensor which comprises an insulating substrate and a graphene filmfixed on the insulating substrate. The graphene film has the characteristics that 1)the surface roughness of the graphene film is less than 1.5 nm; 2)the sheet resistance of the graphene film is lessthan 1000 ohm / sq; 3)The mobility of the graphene film is greater than 2000 cm 2 / V.s. The invention further discloses a detection method for DNA based on the sensor, which can realize no labeling, rapid detection and detection limit as high as 10-12M and is not affected by Debye length.

Description

technical field [0001] The invention relates to the technical field of graphene DNA sensor measurement, in particular to a graphene Hall effect-based DNA sensor and a detection method. Background technique [0002] Graphene, as a two-dimensional material with a single atomic layer, has many excellent properties, such as: ultra-high electron mobility, large specific surface area, excellent mechanical properties and biocompatibility, etc. Due to the special properties of graphene Electricity and morphology make its carrier transport very susceptible to the influence of the external environment. A single molecule adsorbed on the surface can change the electrical properties of graphene, making graphene have broad application prospects in the field of sensors. Among them, it is used to detect glucose, protein, dopamine and DNA in the field of biosensors. As a DNA molecule carrying genetic information, mutations may cause cell cancer. Therefore, the specific recognition of DNA mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
CPCG01N27/3276
Inventor 林正得江南吴冬芹李小晴叶辰
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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